{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1530.00","upperLimit":"3520.00","value":"2510.00"},{"groupId":"OG001","lowerLimit":"1350.00","upperLimit":"4430.00","value":"3260.00"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"13"},{"groupId":"OG001","value":"8"}],"units":"Participants"}],"description":"Responders were AML participants who achieved CR, CRi, MLFS, PR or PRi based on investigator-reported best overall response and MDS participants who achieved CR, mCR, PR or SD based on investigator-reported best overall response. A total of 38 proteins were analyzed. The data of analytes for which the serum level showed statistically significant correlation with clinical response are reported. Post-baseline levels statistically significant associated with best overall response was only seen for SDF-1 (Stromal cell-derived factor 1) at Induction Cycle 1/Day 3.","dispersionType":"Full Range","groups":[{"description":"AML subjects who achieved CR, CRi, MLFS, PR, or PRi (AML investigator reported best overall response), and MDS subjects who achieved CR, mCR, PR, or SD (MDS investigator reported best overall response). Dauno is short for daunorubicin.","id":"OG000","title":"Phase 1B: Glasdegib + Cytarabine/Dauno (Biomarker, Responder)"},{"description":"AML participants who did not achieve CR, CRi, MLFS, PR, or PRi; and MDS participants who did not achieve CR, mCR, PR or SD were defined as non-responders for best overall response. Dauno is short for daunorubicin.","id":"OG001","title":"Phase 1B: Glasdegib+Cytarabine/Dauno(Biomarker,Non-Responder)"}],"paramType":"MEDIAN","populationDescription":"PD analysis set: all enrolled participants in the Phase 1B portion who received at least 1 dose of glasdegib, and had at least 1 PD parameter from the corresponding assay sample with a baseline and an adequate post treatment assessment.","reportingStatus":"POSTED","timeFrame":"Induction Cycle 1/Day 3, 1 Hour Post dose","title":"Post-baseline Levels of Serum Circulating Protein Analytes Associated With Best Overall Response at Phase 1B - Induction Cycle 1/Day 3","type":"SECONDARY","unitOfMeasure":"pg/mL"}