{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1700","upperLimit":"44000","value":"10200"}]}],"title":"MMP-3 (Matrix metalloproteinase-3)"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"0.00","upperLimit":"71.00","value":"10.7"}]}],"title":"IL-8 (Interleukin-8)"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"0.00","upperLimit":"22000","value":"1200"}]}],"title":"BDNF (Brain-derived neurotrophic factor)"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"0.00","upperLimit":"0.00","value":"0.00"}]}],"title":"IL-5 (Interleukin-5)"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"32.00","upperLimit":"2000.00","value":"88.00"}]}],"title":"VEGF (Vascular endothelial growth factor)"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"0.00","upperLimit":"1850.00","value":"180.5"}]}],"title":"MCP-1 (Monocyte chemotactic protein-1)"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"0.00","upperLimit":"1900.00","value":"0.00"}]}],"title":"ITAC:Interferon-inducible T-cell α chemoattractant"}],"denoms":[{"counts":[{"groupId":"OG000","value":"22"}],"units":"Participants"}],"description":"Serum levels were determined for 38 circulating proteins. Values showing statistically significant, ≥2-fold difference compared with baseline are reported here.","dispersionType":"Full Range","groups":[{"description":"Included all participants who received oral glasdegib in combination with cytarabine/daunorubicin in phase 1B portion.","id":"OG000","title":"Phase 1B: Glasdegib + Cytarabine/Daunorubicin"}],"paramType":"MEDIAN","populationDescription":"Pharmacodynamic (PD) analysis set: all enrolled participants in the Phase 1B portion who received at least 1 dose of glasdegib, and had at least 1 PD parameter from the corresponding assay sample with a baseline and an adequate post treatment assessment.","reportingStatus":"POSTED","timeFrame":"Baseline (Induction Cycle 1/Day -3 pre-dose)","title":"Serum Levels of Circulating Protein Analytes at Phase 1B - Baseline","type":"SECONDARY","unitOfMeasure":"pg/mL"}