{"analyses":[{"ciLowerLimit":"0.727","ciNumSides":"TWO_SIDED","ciPctValue":"95","ciUpperLimit":"0.973","groupDescription":"A Cox proportional-hazards model, stratified by race, was used to estimate the hazard ratio and 95% confidence interval (CI) between the two treatment groups.","groupIds":["OG000","OG001"],"nonInferiorityType":"SUPERIORITY_OR_OTHER","pValue":"0.0193","pValueComment":"P-value from log-rank stratified by Race (two-sided). Hazard ratio (Afatinib vs Erlotinib) from Cox proportional hazards model stratified by Race.","paramType":"Hazard Ratio (HR)","paramValue":"0.841","statisticalMethod":"Log Rank"}],"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"7.19","upperLimit":"8.71","value":"7.82"},{"groupId":"OG001","lowerLimit":"5.85","upperLimit":"7.79","value":"6.77"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"398"},{"groupId":"OG001","value":"397"}],"units":"Participants"}],"description":"Overall Survival is defined as the time from randomisation to death. It was a key secondary endpoint.","dispersionType":"95% Confidence Interval","groups":[{"description":"Patients administered 40 milligram (mg) film-coated tablet once daily orally for the first 28-day treatment course. Dose escalation to 50 mg once daily was allowed at the beginning of the second 28-day treatment course, if patients met specified safety and compliance criteria. Dose reduction to 40 mg/day (if applicable), 30 mg/day, or 20 mg/day, was required in the presence of known drug-related adverse events.","id":"OG000","title":"Afatinib"},{"description":"Patients administered 150 mg film-coated tablet once daily orally, with dose reduction to 100 mg/day or 50 mg/day in the presence of known drug-related adverse events.","id":"OG001","title":"Erlotinib"}],"paramType":"MEDIAN","populationDescription":"RS","reportingStatus":"POSTED","timeFrame":"From first drug administration from 9 April 2012 until study closure on 27 Dec 2017 (approximately 2089 days).","title":"Overall Survival","type":"SECONDARY","unitOfMeasure":"Months"}