{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","value":"14"}]}],"title":"DBP, Week 1, RRH, n=87"},{"categories":[{"measurements":[{"groupId":"OG000","value":"8"}]}],"title":"DBP, Week 1, RRL, n=87"},{"categories":[{"measurements":[{"groupId":"OG000","value":"14"}]}],"title":"DBP, Week 2, RRH, n=86"},{"categories":[{"measurements":[{"groupId":"OG000","value":"8"}]}],"title":"DBP, Week 2, RRL, n=86"},{"categories":[{"measurements":[{"groupId":"OG000","value":"13"}]}],"title":"DBP, Week 3, RRH, n=86"},{"categories":[{"measurements":[{"groupId":"OG000","value":"11"}]}],"title":"DBP, Week 3, RRL, n=86"},{"categories":[{"measurements":[{"groupId":"OG000","value":"10"}]}],"title":"DBP, Week 4, RRH, n=68"},{"categories":[{"measurements":[{"groupId":"OG000","value":"7"}]}],"title":"DBP, Week 4, RRL, n=68"},{"categories":[{"measurements":[{"groupId":"OG000","value":"7"}]}],"title":"DBP, Week 5, RRH, n=61"},{"categories":[{"measurements":[{"groupId":"OG000","value":"7"}]}],"title":"DBP, Week 5, RRL, n=61"},{"categories":[{"measurements":[{"groupId":"OG000","value":"6"}]}],"title":"DBP, Week 6, RRH, n=55"},{"categories":[{"measurements":[{"groupId":"OG000","value":"4"}]}],"title":"DBP, Week 6, RRL, n=55"},{"categories":[{"measurements":[{"groupId":"OG000","value":"7"}]}],"title":"DBP, Week 7, RRH, n=52"},{"categories":[{"measurements":[{"groupId":"OG000","value":"5"}]}],"title":"DBP, Week 7, RRL, n=52"},{"categories":[{"measurements":[{"groupId":"OG000","value":"4"}]}],"title":"DBP, Week 8, RRH, n=53"},{"categories":[{"measurements":[{"groupId":"OG000","value":"6"}]}],"title":"DBP, Week 8, RRL, n=53"},{"categories":[{"measurements":[{"groupId":"OG000","value":"3"}]}],"title":"DBP, Week 9, RRH, n=45"},{"categories":[{"measurements":[{"groupId":"OG000","value":"7"}]}],"title":"DBP, Week 9, RRL, n=45"},{"categories":[{"measurements":[{"groupId":"OG000","value":"5"}]}],"title":"DBP, 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n=38"},{"categories":[{"measurements":[{"groupId":"OG000","value":"7"}]}],"title":"DBP, Week 15, RRH, n=43"},{"categories":[{"measurements":[{"groupId":"OG000","value":"3"}]}],"title":"DBP, Week 15, RRL, n=43"},{"categories":[{"measurements":[{"groupId":"OG000","value":"3"}]}],"title":"DBP, Week 16, RRH, n=47"},{"categories":[{"measurements":[{"groupId":"OG000","value":"6"}]}],"title":"DBP, Week 16, RRL, n=47"},{"categories":[{"measurements":[{"groupId":"OG000","value":"5"}]}],"title":"DBP, Week 17, RRH, n=37"},{"categories":[{"measurements":[{"groupId":"OG000","value":"6"}]}],"title":"DBP, Week 17, RRL, n=37"},{"categories":[{"measurements":[{"groupId":"OG000","value":"7"}]}],"title":"DBP, Week 18, RRH, n=34"},{"categories":[{"measurements":[{"groupId":"OG000","value":"5"}]}],"title":"DBP, Week 18, RRL, n=34"},{"categories":[{"measurements":[{"groupId":"OG000","value":"5"}]}],"title":"DBP, Week 19, RRH, n=44"},{"categories":[{"measurements":[{"groupId":"OG000","value":"3"}]}],"title":"DBP, Week 19, RRL, n=44"},{"categories":[{"measurements":[{"groupId":"OG000","value":"6"}]}],"title":"DBP, Week 20, RRH, n=39"},{"categories":[{"measurements":[{"groupId":"OG000","value":"3"}]}],"title":"DBP, Week 20, RRL, n=39"},{"categories":[{"measurements":[{"groupId":"OG000","value":"9"}]}],"title":"DBP, Week 21, RRH, n=41"},{"categories":[{"measurements":[{"groupId":"OG000","value":"6"}]}],"title":"DBP, Week 21, RRL, n=41"},{"categories":[{"measurements":[{"groupId":"OG000","value":"6"}]}],"title":"DBP, Week 22, RRH, n=34"},{"categories":[{"measurements":[{"groupId":"OG000","value":"3"}]}],"title":"DBP, Week 22, RRL, n=34"},{"categories":[{"measurements":[{"groupId":"OG000","value":"6"}]}],"title":"DBP, Week 23, RRH, n=36"},{"categories":[{"measurements":[{"groupId":"OG000","value":"6"}]}],"title":"DBP, Week 23, RRL, n=36"},{"categories":[{"measurements":[{"groupId":"OG000","value":"14"}]}],"title":"DBP, Week 24, RRH, n=79"},{"categories":[{"measurements":[{"groupId":"OG000","value":"10"}]}],"title":"DBP, Week 24, RRL, n=79"},{"categories":[{"measurements":[{"groupId":"OG000","value":"8"}]}],"title":"DBP, Follow-Up Week 1, RRH, n=29"},{"categories":[{"measurements":[{"groupId":"OG000","value":"3"}]}],"title":"DBP, Follow-Up Week 1, RRL, n=29"},{"categories":[{"measurements":[{"groupId":"OG000","value":"8"}]}],"title":"DBP, Follow-Up Week 2, RRH, n=37"},{"categories":[{"measurements":[{"groupId":"OG000","value":"6"}]}],"title":"DBP, Follow-Up Week 2, RRL, n=37"},{"categories":[{"measurements":[{"groupId":"OG000","value":"4"}]}],"title":"DBP, Follow-Up Week 3, RRH, n=39"},{"categories":[{"measurements":[{"groupId":"OG000","value":"5"}]}],"title":"DBP, Follow-Up Week 3, RRL, n=39"},{"categories":[{"measurements":[{"groupId":"OG000","value":"8"}]}],"title":"DBP, Follow-Up Week 4, RRH, n=67"},{"categories":[{"measurements":[{"groupId":"OG000","value":"5"}]}],"title":"DBP, Follow-Up Week 4, RRL, n=67"},{"categories":[{"measurements":[{"groupId":"OG000","value":"4"}]}],"title":"Heart Rate, Week 1, RRH, n=87"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"}]}],"title":"Heart Rate, Week 1, RRL, n=87"},{"categories":[{"measurements":[{"groupId":"OG000","value":"3"}]}],"title":"Heart Rate, Week 2, RRH, n=86"},{"categories":[{"measurements":[{"groupId":"OG000","value":"2"}]}],"title":"Heart Rate, Week 2, RRL, n=86"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"}]}],"title":"Heart Rate, Week 3, RRH, n=86"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Heart Rate, Week 3, RRL, n=86"},{"categories":[{"measurements":[{"groupId":"OG000","value":"2"}]}],"title":"Heart Rate, Week 4, RRH, n=68"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Heart Rate, Week 4, RRL, n=68"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Heart Rate, Week 5, RRH, n=61"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"}]}],"title":"Heart Rate, Week 5, RRL, n=61"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"}]}],"title":"Heart Rate, Week 6, RRH, n=55"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Heart Rate, Week 6, RRL, n=55"},{"categories":[{"measurements":[{"groupId":"OG000","value":"2"}]}],"title":"Heart Rate, Week 7, RRH, n=52"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Heart Rate, Week 7, RRL, n=52"},{"categories":[{"measurements":[{"groupId":"OG000","value":"2"}]}],"title":"Heart Rate, Week 8, RRH, n=53"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Heart Rate, Week 8, RRL, n=53"},{"categories":[{"measurements":[{"groupId":"OG000","value":"2"}]}],"title":"Heart Rate, Week 9, RRH, n=45"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Heart Rate, Week 9, RRL, n=45"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"}]}],"title":"Heart Rate, Week 10, RRH, n=42"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"}]}],"title":"Heart Rate, Week 10, RRL, n=42"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"}]}],"title":"Heart Rate, Week 11, RRH, n=40"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"}]}],"title":"Heart Rate, Week 11, RRL, n=40"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"}]}],"title":"Heart Rate, Week 12, RRH, n=63"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"}]}],"title":"Heart Rate, Week 12, RRL, n=63"},{"categories":[{"measurements":[{"groupId":"OG000","value":"2"}]}],"title":"Heart Rate, Week 13, RRH, n=29"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Heart Rate, Week 13, RRL, n=29"},{"categories":[{"measurements":[{"groupId":"OG000","value":"2"}]}],"title":"Heart Rate, Week 14, RRH, n=38"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"}]}],"title":"Heart Rate, Week 14, RRL, n=38"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Heart Rate, Week 15, RRH, n=43"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Heart Rate, Week 15, RRL, n=43"},{"categories":[{"measurements":[{"groupId":"OG000","value":"2"}]}],"title":"Heart Rate, Week 16, RRH, n=47"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Heart Rate, Week 16, RRL, n=47"},{"categories":[{"measurements":[{"groupId":"OG000","value":"2"}]}],"title":"Heart Rate, Week 17, RRH, n=37"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"}]}],"title":"Heart Rate, Week 17, RRL, n=37"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Heart Rate, Week 18, RRH, n=34"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Heart Rate, Week 18, RRL, n=34"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Heart Rate, Week 19, RRH, n=44"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"}]}],"title":"Heart Rate, Week 19, RRL, n=44"},{"categories":[{"measurements":[{"groupId":"OG000","value":"2"}]}],"title":"Heart Rate, Week 20, RRH, n=39"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Heart Rate, Week 20, RRL, n=39"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Heart Rate, Week 21, RRH, n=41"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Heart Rate, Week 21, RRL, n=41"},{"categories":[{"measurements":[{"groupId":"OG000","value":"2"}]}],"title":"Heart Rate, Week 22, RRH, n=34"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Heart Rate, Week 22, RRL, n=34"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Heart Rate, Week 23, RRH, n=36"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Heart Rate, Week 23, RRL, n=36"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"}]}],"title":"Heart Rate, Week 24, RRH, n=79"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"}]}],"title":"Heart Rate, Week 24, RRL, n=79"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"}]}],"title":"Heart Rate, Follow-Up Week 1, RRH, n=29"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Heart Rate, Follow-Up Week 1, RRL, n=29"},{"categories":[{"measurements":[{"groupId":"OG000","value":"2"}]}],"title":"Heart Rate, Follow-Up Week 2, RRH, n=37"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"}]}],"title":"Heart Rate, Follow-Up Week 2, RRL, n=37"},{"categories":[{"measurements":[{"groupId":"OG000","value":"2"}]}],"title":"Heart Rate, Follow-Up Week 3, RRH, n=39"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Heart Rate, Follow-Up Week 3, RRL, n=39"},{"categories":[{"measurements":[{"groupId":"OG000","value":"2"}]}],"title":"Heart Rate, Follow-Up Week 4, RRH, n=67"},{"categories":[{"measurements":[{"groupId":"OG000","value":"2"}]}],"title":"Heart Rate, Follow-Up Week 4, RRL, n=67"},{"categories":[{"measurements":[{"groupId":"OG000","value":"13"}]}],"title":"SBP, Week 1, RRH, n=87"},{"categories":[{"measurements":[{"groupId":"OG000","value":"9"}]}],"title":"SBP, Week 1, RRL, n=87"},{"categories":[{"measurements":[{"groupId":"OG000","value":"19"}]}],"title":"SBP, Week 2, RRH, n=86"},{"categories":[{"measurements":[{"groupId":"OG000","value":"16"}]}],"title":"SBP, Week 2, RRL, n=86"},{"categories":[{"measurements":[{"groupId":"OG000","value":"15"}]}],"title":"SBP, Week 3, RRH, n=86"},{"categories":[{"measurements":[{"groupId":"OG000","value":"13"}]}],"title":"SBP, Week 3, RRL, n=86"},{"categories":[{"measurements":[{"groupId":"OG000","value":"10"}]}],"title":"SBP, Week 4, RRH, n=68"},{"categories":[{"measurements":[{"groupId":"OG000","value":"7"}]}],"title":"SBP, Week 4, RRL, n=68"},{"categories":[{"measurements":[{"groupId":"OG000","value":"7"}]}],"title":"SBP, Week 5, RRH, n=61"},{"categories":[{"measurements":[{"groupId":"OG000","value":"8"}]}],"title":"SBP, Week 5, RRL, n=61"},{"categories":[{"measurements":[{"groupId":"OG000","value":"11"}]}],"title":"SBP, Week 6, RRH, n=55"},{"categories":[{"measurements":[{"groupId":"OG000","value":"7"}]}],"title":"SBP, Week 6, RRL, n=55"},{"categories":[{"measurements":[{"groupId":"OG000","value":"10"}]}],"title":"SBP, Week 7, RRH, n=52"},{"categories":[{"measurements":[{"groupId":"OG000","value":"5"}]}],"title":"SBP, Week 7, RRL, n=52"},{"categories":[{"measurements":[{"groupId":"OG000","value":"8"}]}],"title":"SBP, Week 8, RRH, n=53"},{"categories":[{"measurements":[{"groupId":"OG000","value":"5"}]}],"title":"SBP, 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n=29"},{"categories":[{"measurements":[{"groupId":"OG000","value":"2"}]}],"title":"SBP, Week 13, RRL, n=29"},{"categories":[{"measurements":[{"groupId":"OG000","value":"5"}]}],"title":"SBP, Week 14, RRH, n=38"},{"categories":[{"measurements":[{"groupId":"OG000","value":"7"}]}],"title":"SBP, Week 14, RRL, n=38"},{"categories":[{"measurements":[{"groupId":"OG000","value":"9"}]}],"title":"SBP, Week 15, RRH, n=43"},{"categories":[{"measurements":[{"groupId":"OG000","value":"7"}]}],"title":"SBP, Week 15, RRL, n=43"},{"categories":[{"measurements":[{"groupId":"OG000","value":"7"}]}],"title":"SBP, Week 16, RRH, n=47"},{"categories":[{"measurements":[{"groupId":"OG000","value":"6"}]}],"title":"SBP, Week 16, RRL, n=47"},{"categories":[{"measurements":[{"groupId":"OG000","value":"9"}]}],"title":"SBP, Week 17, RRH, n=37"},{"categories":[{"measurements":[{"groupId":"OG000","value":"4"}]}],"title":"SBP, Week 17, RRL, n=37"},{"categories":[{"measurements":[{"groupId":"OG000","value":"6"}]}],"title":"SBP, Week 18, RRH, n=34"},{"categories":[{"measurements":[{"groupId":"OG000","value":"5"}]}],"title":"SBP, Week 18, RRL, n=34"},{"categories":[{"measurements":[{"groupId":"OG000","value":"7"}]}],"title":"SBP, Week 19, RRH, n=44"},{"categories":[{"measurements":[{"groupId":"OG000","value":"4"}]}],"title":"SBP, Week 19, RRL, n=44"},{"categories":[{"measurements":[{"groupId":"OG000","value":"5"}]}],"title":"SBP, Week 20, RRH, n=39"},{"categories":[{"measurements":[{"groupId":"OG000","value":"5"}]}],"title":"SBP, Week 20, RRL, n=39"},{"categories":[{"measurements":[{"groupId":"OG000","value":"10"}]}],"title":"SBP, Week 21, RRH, n=41"},{"categories":[{"measurements":[{"groupId":"OG000","value":"6"}]}],"title":"SBP, Week 21, RRL, n=41"},{"categories":[{"measurements":[{"groupId":"OG000","value":"6"}]}],"title":"SBP, Week 22, RRH, n=34"},{"categories":[{"measurements":[{"groupId":"OG000","value":"4"}]}],"title":"SBP, Week 22, RRL, n=34"},{"categories":[{"measurements":[{"groupId":"OG000","value":"6"}]}],"title":"SBP, Week 23, RRH, n=36"},{"categories":[{"measurements":[{"groupId":"OG000","value":"3"}]}],"title":"SBP, Week 23, RRL, n=36"},{"categories":[{"measurements":[{"groupId":"OG000","value":"13"}]}],"title":"SBP, Week 24, RRH, n=79"},{"categories":[{"measurements":[{"groupId":"OG000","value":"12"}]}],"title":"SBP, Week 24, RRL, n=79"},{"categories":[{"measurements":[{"groupId":"OG000","value":"5"}]}],"title":"SBP, Follow-Up Week 1, RRH, n=29"},{"categories":[{"measurements":[{"groupId":"OG000","value":"3"}]}],"title":"SBP, Follow-Up Week 1, RRL, n=29"},{"categories":[{"measurements":[{"groupId":"OG000","value":"5"}]}],"title":"SBP, Follow-Up Week 2, RRH, n=37"},{"categories":[{"measurements":[{"groupId":"OG000","value":"7"}]}],"title":"SBP, Follow-Up Week 2, RRL, n=37"},{"categories":[{"measurements":[{"groupId":"OG000","value":"9"}]}],"title":"SBP, Follow-Up Week 3, RRH, n=39"},{"categories":[{"measurements":[{"groupId":"OG000","value":"4"}]}],"title":"SBP, Follow-Up Week 3, RRL, n=39"},{"categories":[{"measurements":[{"groupId":"OG000","value":"9"}]}],"title":"SBP, Follow-Up Week 4, RRH, n=67"},{"categories":[{"measurements":[{"groupId":"OG000","value":"7"}]}],"title":"SBP, Follow-Up Week 4, RRL, n=67"}],"denoms":[{"counts":[{"groupId":"OG000","value":"87"}],"units":"Participants"}],"description":"Vital sign measurements were taken before any blood draw and included systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate(HR). The number of participants are reported with vital sign data falling outside the standard RR as reference range high(RRH) and reference range low(RRL) from SCR up to Week 24 of Part 2 and from Follow-up Week 1 to Week 4. RR for Blood Pressure(mmHg) are read as: Lower Limit of Normal, Normal Range, Upper Limit of Normal. For Ages 1 to 5 years (yrs) ranges are SBP \\<85, 85 to 115, \\>115; DBP \\<45, 45 to70, \\>70. Ages 6 to 11 yrs: SBP \\<85, 85 to 120, \\>120; DBP \\<50, 50 to 75, \\>75. Ages 12 to 17 yrs: SBP \\<95, 95 to 135, \\>135; DBP \\<55, 55 to 85, \\>85. RR for HR (bpm) are ages 1 to \\< 3 yrs: \\<90, 90 to 140, \\>140; ages 3 to \\< 5 yrs: \\<75, 75 to 130, \\>130, ages 5 to \\< 8yrs: \\<65, 65 to 115, \\>115; ages 8 to \\< 12yrs: \\<55, 55 to 110, \\>110; and ages 12 to 18 yrs: \\<55, 55 to 110, \\>110.","groups":[{"description":"Participants who received eltrombopag in Part 1 continued on the same dose in Part 2 unless adjustments were warranted according to the dosing guidelines. Participants who received placebo in Part 1 received Eltrombopag as per age criteria as follows: aged between 6 and 17 years with a body weight \\<27 kg received eltrombopag 37.5 mg QD, and those with a body weight \\>=27 kg received eltrombopag 50 mg QD. Participants of East Asian ancestry received a starting dose of eltrombopag 25 mg QD. Participants aged between 1 and 5 years received eltrombopag 1.2 mg/kg QD and; participants of East Asian ancestry received a starting dose of eltrombopag 0.8 mg/kg/day.","id":"OG000","title":"Part 2 (Open-Label Period) - Eltrombopag"}],"paramType":"NUMBER","populationDescription":"Safety Population. Only those participants who entered into Part 2 (Open-label eltrombopag-only phase) were analyzed. Only those participants available at the specified time points were analyzed (represented by n=X in the category titles).","reportingStatus":"POSTED","timeFrame":"From Week 1 up to Week 24 of Part 2 and Follow-up Week 1 to Week 4 (up to Week 41)","title":"Number of Participants With Vital Sign Data Falling Outside the Reference Ranges (RR) at the Indicated Visit During Part 2","type":"SECONDARY","unitOfMeasure":"Participants"}