{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"0","upperLimit":"0","value":"0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"9"}],"units":"Participants"}],"title":"Baseline"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"0.09","upperLimit":"13.64","value":"6.51"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"9"}],"units":"Participants"}],"title":"Day 15 of protocol therapy"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"3.33","upperLimit":"10.10","value":"6.99"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"4"}],"units":"Participants"}],"title":"Day 56 of protocol therapy"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"4.10","upperLimit":"4.10","value":"4.10"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"}],"units":"Participants"}],"title":"Day 112 of protocol therapy"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"5.20","upperLimit":"5.20","value":"5.20"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"}],"units":"Participants"}],"title":"Day 168 of protocol therapy"}],"denoms":[{"counts":[{"groupId":"OG000","value":"9"}],"units":"Participants"}],"description":"The trough sorafenib concentration is evaluated at baseline (prior to administration of Sorafenib) and 12 hours after administration of Sorafenib on day 15, day 56, day 112 and day 168 in micrograms/ml.","dispersionType":"Full Range","groups":[{"description":"Serum concentration are the responses of the patient's organs to the drug. As such, these measures are unrelated to the particular disease with which the patient was diagnosed and were combined for analysis.","id":"OG000","title":"Rhabdomyosarcoma and Wilms Tumor"}],"paramType":"MEAN","populationDescription":"Baseline sample was available for only 9 participants.","reportingStatus":"POSTED","timeFrame":"Prior to administration of Sorafenib (baseline), day 15, day 56, day 112 and day 168","title":"Pharmacokinetic (PK) Parameters of Sorafenib Tosylate","type":"SECONDARY","unitOfMeasure":"micrograms/ml"}