{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.567","value":"1.44"},{"groupId":"OG001","spread":"0.985","value":"2.21"},{"groupId":"OG002","spread":"1.35","value":"1.90"},{"groupId":"OG003","spread":"0.923","value":"1.96"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"13"},{"groupId":"OG001","value":"16"},{"groupId":"OG002","value":"18"},{"groupId":"OG003","value":"43"}],"units":"Participants"}],"description":"Ibrutinib and PCI-45227 concentrations were measurable following once-daily dosing of ibrutinib in subjects with MM. The following time-points were included: 0hr, 1hr, 2hr, 7hr, 24hr post-dose. Calculated as (PCI-45227 AUC0-24h/PCI-45227 molecular weight)/(ibrutinib AUC0-24h/ibrutinib molecular weight) on Day 8.","dispersionType":"Standard Deviation","groups":[{"description":"PCI-32765 420 mg per day\n\nPCI-32765","id":"OG000","title":"Cohort 1"},{"description":"PCI-32765 560 mg per day, 40 mg dexamethasone (oral) once per week\n\nPCI-32765\n\nDexamethasone","id":"OG001","title":"Cohort 2"},{"description":"PCI-32765 840 mg per day\n\nPCI-32765","id":"OG002","title":"Cohort 3"},{"description":"PCI-32765 840 mg per day, 40 mg dexamethasone (oral) once per week\n\nPCI-32765\n\nDexamethasone","id":"OG003","title":"Cohort 4"}],"paramType":"MEAN","populationDescription":"All subjects who received at least one dose of study treatment and had evaluable pharmacokinetic data.","reportingStatus":"POSTED","timeFrame":"Procedure was performed up to 60 weeks.","title":"Pharmacokinetics (PK) (Assessed by Sampling and Testing for Drug and Metabolite Levels at Designated Time Points). Mean Metabolite-to-Parent Ratio for AUC0-24h (M/P AUC0-24h)","type":"SECONDARY","unitOfMeasure":"Ratio"}