{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","value":"16"},{"groupId":"OG001","value":"16"},{"groupId":"OG002","value":"16"},{"groupId":"OG003","value":"16"},{"groupId":"OG004","value":"16"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"31"},{"groupId":"OG001","value":"4"},{"groupId":"OG002","value":"18"},{"groupId":"OG003","value":"21"},{"groupId":"OG004","value":"17"}],"units":"Participants"}],"description":"1. as monotherapy\n2. in combination with dexamethasone\n3. in combination with pomalidomide + dexamethasone\n4. in combination with lenalidomide + dexamethasone","groups":[{"description":"Treatment cycle 28 days, MOR03087 doses applied day 1 \\& 15, initial 0.01 mg/kg, max 16 mg/kg","id":"OG000","title":"Part A: MOR03087 Biweekly Dose Escalation"},{"description":"Treatment cycle 28 days, MOR03087 doses applied day 1, 8, 15 \\& 22 plus extra dose on day 4 of cycle 1, Initial MOR03087 dose 4 mg/kg, max 16 mg/kg","id":"OG001","title":"Part B: MOR03087 Weekly Dose Escalation"},{"description":"Treatment cycle 28 days, iv MOR03087 and oral dexamethasone (DEX) applied day 1, 8, 15 \\& 22 plus extra dose on day 4 of cycle 1, initial MOR03087 dose 4 mg/kg, max 16 mg/kg. DEX dose 40 mg (≤ 75 years old) or 20 mg (\\> 75 years old)","id":"OG002","title":"Part C: MOR03087 Plus Dexamethasone"},{"description":"Treatment cycle 28 days, iv MOR03087 and oral dexamethasone (DEX) applied day 1, 8, 15 \\& 22 plus extra dose on day 4 of cycle 1, initial MOR03087 dose 8 mg/kg, max 16 mg/kg. DEX dose 40 mg (≤ 75 years old) or 20 mg (\\> 75 years old). Pomalidomide was administered to patients orally 4 mg on days 1-21 of the 28-day cycle.","id":"OG003","title":"Part D: MOR03087 Plus Pomalidomide + Dexamethasone"},{"description":"Treatment cycle 28 days, iv MOR03087 and oral dexamethasone (DEX) applied day 1, 8, 15 \\& 22 plus extra dose on day 4 of cycle 1, initial MOR03087 dose 8 mg/kg, max 16 mg/kg. DEX dose 40 mg (≤ 75 years old) or 20 mg (\\> 75 years old).\n\nLenalidomide was administered to patients orally 25 mg on days 1-21 of the 28-day cycle.","id":"OG004","title":"Part E: MOR03087 Plus Lenalidomide + Dexamethasone"}],"paramType":"NUMBER","reportingStatus":"POSTED","timeFrame":"First cycle of treatment","title":"Determination of Maximum Tolerated Dose and / or Recommended Dose and Dosing Regimen of MOR03087","type":"PRIMARY","unitOfMeasure":"mg/kg"}