{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"54.7","upperLimit":"60.7","value":"59.8"},{"groupId":"OG001","lowerLimit":"32.3","upperLimit":"62.3","value":"48.4"},{"groupId":"OG002","lowerLimit":"54.1","upperLimit":"54.1","value":"54.1"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"4"},{"groupId":"OG002","value":"1"}],"units":"Participants"}],"description":"Blood samples were collected before and 30 minutes after the start of infusion and immediately (0 minutes), 30, 60, 90, and 120 minutes after the end of infusion of denileukin diftitox. The samples were analyzed for the amount of denileukin diftitox in the serum using a validated ligand-binding assay with a LLOQ of 30 ng/mL. Serum PK data were analyzed using a non-compartmental analysis approach to obtain individual participant estimates of Vss, which was then summarized as the median and full range for all participants and expressed as mL/kg.","dispersionType":"Full Range","groups":[{"description":"Denileukin diftitox (6 ug/kg/day) was IV-infused for 60 minutes (±10 minutes) daily from Day 1 through Day 5 of each Cycle (1 cycle = 3 weeks).","id":"OG000","title":"Cohort 1: 6 ug/kg/Day Denileukin Diftitox"},{"description":"Denileukin diftitox (9 ug/kg/day) was IV-infused for 60 minutes (±10 minutes) daily from Day 1 through Day 5 of each Cycle (1 cycle = 3 weeks).","id":"OG001","title":"Cohort 2: 9 ug/kg/Day Denileukin Diftitox"},{"description":"Denileukin diftitox (12 ug/kg/day) was IV-infused for 60 minutes (±10 minutes) daily from Day 1 through Day 5 of each Cycle (1 cycle = 3 weeks).","id":"OG002","title":"Cohort 3: 12 ug/kg/Day Denileukin Diftitox"}],"paramType":"MEDIAN","populationDescription":"PK analysis set","reportingStatus":"POSTED","timeFrame":"Cycle 1 (Day 1)","title":"Volume of Distribution at Steady State (Vss)","type":"SECONDARY","unitOfMeasure":"mL/kg"}