{"classes":[{"categories":[{"measurements":[{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG000","spread":"NA","value":"6.77"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG001","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG002","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG003","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG004","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG005","spread":"NA","value":"NA"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG006","spread":"NA","value":"10.55"}]}],"title":"DDI Day 1: Predose (n= 1, 0, 0, 0, 0, 0, 1)"},{"categories":[{"measurements":[{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG000","spread":"NA","value":"8.74"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG001","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG002","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG003","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG004","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG005","spread":"NA","value":"NA"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG006","spread":"NA","value":"10.17"}]}],"title":"DDI Day 1: 2 hr post-dose (n=1,0,0,0,0.0,1)"},{"categories":[{"measurements":[{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG000","spread":"NA","value":"6.10"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG001","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG002","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG003","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG004","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG005","spread":"NA","value":"NA"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG006","spread":"NA","value":"6.50"}]}],"title":"DDI Day 1: 4 hr post-dose ((n=1,0,0,0,0,0,1)"},{"categories":[{"measurements":[{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG000","spread":"NA","value":"7.42"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG001","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG002","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG003","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG004","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG005","spread":"NA","value":"NA"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG006","spread":"NA","value":"9.36"}]}],"title":"DDI Day 1: 8 hr post-dose(n= 1, 0, 0, 0, 0, 0, 1)"},{"categories":[{"measurements":[{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG000","spread":"NA","value":"10.84"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG001","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG002","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG003","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG004","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG005","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG006","spread":"NA","value":"NA"}]}],"title":"DDI Day 1: 24 hr post-dose (n=1,0,0,0,0,0,0)"},{"categories":[{"measurements":[{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG000","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG001","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG002","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG003","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG004","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG005","spread":"NA","value":"NA"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG006","spread":"NA","value":"8.32"}]}],"title":"DDI Day 2: 24 hr post-dose ((n= 0,0,0,0,0,0,1)"},{"categories":[{"measurements":[{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG000","spread":"NA","value":"9.46"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG001","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG002","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG003","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG004","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG005","spread":"NA","value":"NA"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG006","spread":"NA","value":"8.94"}]}],"title":"DDI Day 3: Pre-dose (n= 1, 0, 0, 0, 0, 0, 1)"},{"categories":[{"measurements":[{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG000","spread":"NA","value":"3.12"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG001","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG002","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG003","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG004","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG005","spread":"NA","value":"NA"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG006","spread":"NA","value":"15.82"}]}],"title":"DDI Day 3: 2 hr post-dose (n=1,0,0,0,0,0,1)"},{"categories":[{"measurements":[{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG000","spread":"NA","value":"6.74"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG001","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG002","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG003","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG004","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG005","spread":"NA","value":"NA"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG006","spread":"NA","value":"0.68"}]}],"title":"DDI Day 3: 4 hr post-dose (n-1,0,0,0,0,0,1)"},{"categories":[{"measurements":[{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG000","spread":"NA","value":"0.81"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG001","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG002","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG003","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG004","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG005","spread":"NA","value":"NA"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG006","spread":"NA","value":"15.68"}]}],"title":"DDI Day 3: 8 hr post-dose(n= 1, 0, 0, 0, 0, 0, 1)"},{"categories":[{"measurements":[{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG000","spread":"NA","value":"6.18"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG001","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG002","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG003","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG004","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG005","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG006","spread":"NA","value":"NA"}]}],"title":"DDI Day 3: 24 hr post-dose (n=1,0,0,0,0,0,0)"},{"categories":[{"measurements":[{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG000","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG001","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG002","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG003","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG004","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG005","spread":"NA","value":"NA"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG006","spread":"NA","value":"1.06"}]}],"title":"DDI Day 4: 24 hr post-dose (n=0,0,0,0,0,0,1)"},{"categories":[{"measurements":[{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG000","spread":"NA","value":"5.56"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG001","spread":"NA","value":"3.45"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG002","spread":"NA","value":"6.96"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG003","spread":"NA","value":"3.25"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG004","spread":"NA","value":"3.35"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG005","spread":"NA","value":"1.97"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG006","spread":"NA","value":"7.42"}]}],"title":"C1D1: Pre dose (n=1,1,1,1,1,1,1)"},{"categories":[{"measurements":[{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG000","spread":"NA","value":"2.37"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG001","spread":"NA","value":"1.33"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG002","spread":"NA","value":"2.78"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG003","spread":"NA","value":"1.54"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG004","spread":"NA","value":"1.40"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG005","spread":"NA","value":"0.95"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG006","spread":"NA","value":"1.04"}]}],"title":"C1D1: 2hr postdose(n= 1,1,1,1,1,1,1)"},{"categories":[{"measurements":[{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG000","spread":"NA","value":"2.85"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG001","spread":"NA","value":"1.37"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG002","spread":"NA","value":"2.91"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG003","spread":"NA","value":"1.24"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG004","spread":"NA","value":"1.96"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG005","spread":"NA","value":"1.11"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG006","spread":"NA","value":"1.01"}]}],"title":"C1D1: 4hr postdose(n= 1,1,1,1,1,1,1)"},{"categories":[{"measurements":[{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG000","spread":"NA","value":"0.67"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG001","spread":"NA","value":"0.94"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG002","spread":"NA","value":"3.40"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG003","spread":"NA","value":"1.96"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG004","spread":"NA","value":"1.27"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG005","spread":"NA","value":"1.12"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG006","spread":"NA","value":"0.82"}]}],"title":"C1D1: 8hr postdose(n= 1,1,1,1,1,1,1)"},{"categories":[{"measurements":[{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG000","spread":"NA","value":"6.23"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG001","spread":"NA","value":"2.15"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG002","spread":"NA","value":"4.59"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG003","spread":"NA","value":"6.26"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG004","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG005","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG006","spread":"NA","value":"NA"}]}],"title":"C1D1: 24hr postdose(n= 1,1,1,1,0,0,0)"},{"categories":[{"measurements":[{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG000","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG001","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG002","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG003","spread":"NA","value":"NA"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG004","spread":"NA","value":"3.45"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG005","spread":"NA","value":"1.26"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG006","spread":"NA","value":"1.05"}]}],"title":"C1D2: 24hr postdose(n= 0,0,0,0,1,1,1)"},{"categories":[{"measurements":[{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG000","spread":"NA","value":"3.79"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG001","spread":"NA","value":"2.26"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG002","spread":"NA","value":"5.29"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG003","spread":"NA","value":"1.41"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG004","spread":"NA","value":"1.93"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG005","spread":"NA","value":"NA"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG006","spread":"NA","value":"2.03"}]}],"title":"C1D15: pre-dose(n= 1,1,1,1,1,0,1)"},{"categories":[{"measurements":[{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG000","spread":"NA","value":"2.16"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG001","spread":"NA","value":"1.34"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG002","spread":"NA","value":"2.83"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG003","spread":"NA","value":"1.60"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG004","spread":"NA","value":"1.55"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG005","spread":"NA","value":"NA"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG006","spread":"NA","value":"0.94"}]}],"title":"C1D15: 2hr postdose (n= 1,1,1,1,1,0,1)"},{"categories":[{"measurements":[{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG000","spread":"NA","value":"1.87"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG001","spread":"NA","value":"1.34"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG002","spread":"NA","value":"2.50"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG003","spread":"NA","value":"0.94"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG004","spread":"NA","value":"1.20"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG005","spread":"NA","value":"NA"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG006","spread":"NA","value":"0.81"}]}],"title":"C1D15: 4hr postdose (n= 1,1,1,1,1,0,1)"},{"categories":[{"measurements":[{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG000","spread":"NA","value":"1.92"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG001","spread":"NA","value":"2.08"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG002","spread":"NA","value":"3.38"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG003","spread":"NA","value":"1.10"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG004","spread":"NA","value":"1.74"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG005","spread":"NA","value":"NA"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG006","spread":"NA","value":"0.99"}]}],"title":"C1D15: 8hr postdose (n= 1,1,1,1,1,0,1)"},{"categories":[{"measurements":[{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG000","spread":"NA","value":"4.97"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG001","spread":"NA","value":"0.94"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG002","spread":"NA","value":"5.33"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG003","spread":"NA","value":"4.70"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG004","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG005","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG006","spread":"NA","value":"NA"}]}],"title":"C1D15: 24hr postdose (n= 1,1,1,1,0,0,0)"},{"categories":[{"measurements":[{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG000","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG001","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG002","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG003","spread":"NA","value":"NA"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG004","spread":"NA","value":"2.36"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG005","spread":"NA","value":"NA"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG006","spread":"NA","value":"0.99"}]}],"title":"C1D16: 24hr postdose (n= 0,0,0,0,1,0,1)"},{"categories":[{"measurements":[{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG000","spread":"NA","value":"6.54"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG001","spread":"NA","value":"2.61"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG002","spread":"NA","value":"4.47"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG003","spread":"NA","value":"5.44"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG004","spread":"NA","value":"2.07"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG005","spread":"NA","value":"NA"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG006","spread":"NA","value":"5.72"}]}],"title":"C1D19: pre-dose (n= 1,1,1,1,1,0,1)"},{"categories":[{"measurements":[{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG000","spread":"NA","value":"1.60"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG001","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG002","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG003","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG004","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG005","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG006","spread":"NA","value":"NA"}]}],"title":"C1D19: 2hr postdose (n= 1,0,0,0,0,0,0)"}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"1"},{"groupId":"OG003","value":"1"},{"groupId":"OG004","value":"1"},{"groupId":"OG005","value":"3"},{"groupId":"OG006","value":"1"}],"units":"Participants"}],"description":"pERK Concentrations in PBMCs was measured during DDI Evaluation period and Cycle 1 for DE cohorts. DDI evaluation period is a 4-day period that was performed within 1 week prior to Day 1 Cycle 1. In DDI evaluation period, On Day 1, SAR245409 was be administered alone, and on Day 3, Pimasertib was administered alone. No data were planned to be collected for \"Pimasertib (MSC1936369B) 60mg and SAR245409 30mg Twice Daily\", \"Pimasertib (MSC1936369B) 45mg and SAR245409 50mg Twice Daily\", \"Pimasertib (MSC1936369) 30mg and SAR245409 70mg Once Daily\" and \"Pimasertib (MSC1936369B) 60mg and SAR245409 90mg Once Daily\" reporting arms.","dispersionType":"Standard Deviation","groups":[{"description":"Pimasertib (MSC1936369B) capsule was administered at a single oral dose of 15 milligram (mg) along with single oral dose of 30 mg SAR245409 capsule on Day 1 of 21 days cycle until disease progression, intolerable toxicity, Investigator's decision to discontinue treatment, or withdrawal of consent by the subject.","id":"OG000","title":"Pimasertib (MSC1936369B) 15mg and SAR245409 30mg Once Daily"},{"description":"Pimasertib (MSC1936369B) capsule was administered at a single oral dose of 30 mg along with single oral dose of 30 mg SAR245409 capsule on Day 1 of 21 days cycle until disease progression, intolerable toxicity, Investigator's decision to discontinue treatment, or withdrawal of consent by the subject.","id":"OG001","title":"Pimasertib (MSC1936369B) 30mg and SAR245409 30mg Once Daily"},{"description":"Pimasertib (MSC1936369B) capsule was administered at a single oral dose of 15 mg along with single oral dose of 50 mg SAR245409 capsule on Day 1 of 21 days cycle until disease progression, intolerable toxicity, Investigator's decision to discontinue treatment, or withdrawal of consent by the subject.","id":"OG002","title":"Pimasertib (MSC1936369B) 15mg and SAR245409 50mg Once Daily"},{"description":"Pimasertib (MSC1936369B) capsule was administered at a single oral dose of 30 mg along with single oral dose of 50 mg SAR245409 capsule on Day 1 of each 21 days cycle until disease progression, intolerable toxicity, Investigator's decision to discontinue treatment, or withdrawal of consent by the subject.","id":"OG003","title":"Pimasertib (MSC1936369B) 30mg and SAR245409 50mg Once Daily"},{"description":"Pimasertib (MSC1936369B) capsule was administered at a single oral dose of 60 mg along with single oral dose of 50 mg SAR245409 capsule on Day 1 of 21 days cycle until disease progression, intolerable toxicity, Investigator's decision to discontinue treatment, or withdrawal of consent by the subject","id":"OG004","title":"Pimasertib (MSC1936369B) 60mg and SAR245409 50mg Once Daily"},{"description":"Pimasertib (MSC1936369B) capsule was administered at a single oral dose of 60 mg along with single oral dose of 70 mg SAR245409 capsule on Day 1 of 21 days cycle until disease progression, intolerable toxicity, Investigator's decision to discontinue treatment, or withdrawal of consent by the subject.","id":"OG005","title":"Pimasertib (MSC1936369B) 60mg and SAR245409 70mg Once Daily"},{"description":"Pimasertib (MSC1936369B) capsule was administered at a single oral dose of 90 mg along with single oral dose of 70 mg SAR245409 capsule on Day 1 of 21 days cycle until disease progression, intolerable toxicity, Investigator's decision to discontinue treatment, or withdrawal of consent by the subject.","id":"OG006","title":"Pimasertib (MSC1936369B) 90mg and SAR245409 70mg Once Daily"}],"paramType":"MEAN","populationDescription":"Biomarker Analysis Set for pharmacodynamics marker analysis in PBMC included all subjects who received at least first dose of both drugs and had provided at least one pre-dose sample and one post-dose sample. Here \"N\" signifies number of subject analysed for this outcome measure\" and \"n\" signifies number of subject analysed at specific time point.","reportingStatus":"POSTED","timeFrame":"DDI Evaluation: Day 1 and 3 (predose, 2, 4, 8 and 24 hours (hr) postdose); Day 2 and 4 (24 hr postdose); C1D1 and C1D15 (predose, 2, 4, 8, 24 hr postdose); C1D2 and C1D16 (24 hr postdose); C1D19 (predose, 2 hr postdose)","title":"pERK Concentrations in PBMCs","type":"SECONDARY","unitOfMeasure":"fluorescence intensity"}