{"classes":[{"categories":[{"measurements":[{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG000","spread":"NA","value":"61.02"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG001","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG002","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG003","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG004","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG005","spread":"NA","value":"NA"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG006","spread":"NA","value":"33.78"}]}],"title":"DDI Day 1: Pre-dose (n= 1, 0, 0, 0, 0, 0, 1)"},{"categories":[{"measurements":[{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG000","spread":"NA","value":"36.15"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG001","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG002","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG003","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG004","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG005","spread":"NA","value":"NA"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG006","spread":"NA","value":"29.84"}]}],"title":"DDI Day 1: 2hr post-dose (n= 1,0,0,0,0,0,1)"},{"categories":[{"measurements":[{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG000","spread":"NA","value":"89.14"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG001","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG002","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG003","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG004","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG005","spread":"NA","value":"NA"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG006","spread":"NA","value":"30.28"}]}],"title":"DDI Day 1: 4hr post-dose (n= 1,0,0,0,0,0,1)"},{"categories":[{"measurements":[{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG000","spread":"NA","value":"54.54"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG001","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG002","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG003","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG004","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG005","spread":"NA","value":"NA"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG006","spread":"NA","value":"44.88"}]}],"title":"DDI Day 1: 8 hr post-dose(n= 1, 0, 0, 0, 0, 0, 1)"},{"categories":[{"measurements":[{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG000","spread":"NA","value":"88.80"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG001","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG002","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG003","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG004","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG005","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG006","spread":"NA","value":"NA"}]}],"title":"DDI Day 1: 24hr post-dose (n= 1,0,0,0,0,0,0)"},{"categories":[{"measurements":[{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG000","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG001","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG002","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG003","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG004","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG005","spread":"NA","value":"NA"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG006","spread":"NA","value":"28.86"}]}],"title":"DDI Day 2: 24hr post-dose (n= 0,0,0,0,0,0,1)"},{"categories":[{"measurements":[{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG000","spread":"NA","value":"57.51"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG001","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG002","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG003","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG004","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG005","spread":"NA","value":"NA"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG006","spread":"NA","value":"14.90"}]}],"title":"DDI Day 3: Pre-dose (n= 1, 0, 0, 0, 0, 0, 1)"},{"categories":[{"measurements":[{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG000","spread":"NA","value":"55.93"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG001","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG002","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG003","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG004","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG005","spread":"NA","value":"NA"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG006","spread":"NA","value":"34.06"}]}],"title":"DDI Day 3: 2hr post-dose (n= 1,0,0,0,0,0,1)"},{"categories":[{"measurements":[{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG000","spread":"NA","value":"36.76"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG001","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG002","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG003","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG004","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG005","spread":"NA","value":"NA"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG006","spread":"NA","value":"1.03"}]}],"title":"DDI Day 3: 4hr post-dose (n= 1,0,0,0,0,0,1)"},{"categories":[{"measurements":[{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG000","spread":"NA","value":"1.08"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG001","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG002","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG003","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG004","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG005","spread":"NA","value":"NA"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG006","spread":"NA","value":"40.40"}]}],"title":"DDI: Day 3: 8 hr post-dose(n= 1, 0, 0, 0, 0, 0, 1)"},{"categories":[{"measurements":[{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG000","spread":"NA","value":"87.60"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG001","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG002","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG003","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG004","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG005","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG006","spread":"NA","value":"NA"}]}],"title":"DDI:Day 3: 24hr post-dose (n= 1,0,0,0,0,0,0)"},{"categories":[{"measurements":[{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG000","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG001","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG002","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG003","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG004","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG005","spread":"NA","value":"NA"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG006","spread":"NA","value":"1.04"}]}],"title":"DDI Day 4: 24hr post-dose (n= 0,0,0,0,0,0,1)"},{"categories":[{"measurements":[{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG000","spread":"NA","value":"51.32"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG001","spread":"NA","value":"83.52"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG002","spread":"NA","value":"96.98"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG003","spread":"NA","value":"47.09"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG004","spread":"NA","value":"50.17"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG005","spread":"NA","value":"4.18"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG006","spread":"NA","value":"36.03"}]}],"title":"C1D1: Pre dose (n= 1,1,1,1,1,1,1)"},{"categories":[{"measurements":[{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG000","spread":"NA","value":"31.08"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG001","spread":"NA","value":"24.48"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG002","spread":"NA","value":"56.41"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG003","spread":"NA","value":"23.89"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG004","spread":"NA","value":"5.72"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG005","spread":"NA","value":"0.92"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG006","spread":"NA","value":"1.04"}]}],"title":"C1D1: 2hr postdose (n= 1,1,1,1,1,1,1)"},{"categories":[{"measurements":[{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG000","spread":"NA","value":"25.71"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG001","spread":"NA","value":"46.95"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG002","spread":"NA","value":"50.11"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG003","spread":"NA","value":"29.85"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG004","spread":"NA","value":"18.21"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG005","spread":"NA","value":"0.72"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG006","spread":"NA","value":"0.94"}]}],"title":"C1D1: 4hr postdose (n= 1,1,1,1,1,1,1)"},{"categories":[{"measurements":[{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG000","spread":"NA","value":"3.02"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG001","spread":"NA","value":"1.28"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG002","spread":"NA","value":"84.57"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG003","spread":"NA","value":"19.75"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG004","spread":"NA","value":"6.21"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG005","spread":"NA","value":"1.18"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG006","spread":"NA","value":"0.96"}]}],"title":"C1D1: 8hr postdose (n= 1,1,1,1,1,1,1)"},{"categories":[{"measurements":[{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG000","spread":"NA","value":"46.16"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG001","spread":"NA","value":"72.14"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG002","spread":"NA","value":"74.15"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG003","spread":"NA","value":"53.47"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG004","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG005","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG006","spread":"NA","value":"NA"}]}],"title":"C1D1: 24hr postdose(n= 1,1,1,1,0,0,0)"},{"categories":[{"measurements":[{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG000","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG001","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG002","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG003","spread":"NA","value":"NA"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG004","spread":"NA","value":"24.66"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG005","spread":"NA","value":"1.61"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG006","spread":"NA","value":"1.00"}]}],"title":"C1D2: 24hr postdose (n= 0,0,0,0,1,1,1)"},{"categories":[{"measurements":[{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG000","spread":"NA","value":"43.48"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG001","spread":"NA","value":"81.29"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG002","spread":"NA","value":"67.69"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG003","spread":"NA","value":"1.20"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG004","spread":"NA","value":"33.43"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG005","spread":"NA","value":"NA"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG006","spread":"NA","value":"0.98"}]}],"title":"C1D15: pre-dose (n= 1,1,1,1,1,0,1)"},{"categories":[{"measurements":[{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG000","spread":"NA","value":"26.41"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG001","spread":"NA","value":"43.70"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG002","spread":"NA","value":"48.23"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG003","spread":"NA","value":"15.02"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG004","spread":"NA","value":"21.11"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG005","spread":"NA","value":"NA"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG006","spread":"NA","value":"1.06"}]}],"title":"C1D15: 2hr postdose (n= 1,1,1,1,1,0,1)"},{"categories":[{"measurements":[{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG000","spread":"NA","value":"41.34"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG001","spread":"NA","value":"53.37"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG002","spread":"NA","value":"92.67"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG003","spread":"NA","value":"0.96"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG004","spread":"NA","value":"19.68"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG005","spread":"NA","value":"NA"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG006","spread":"NA","value":"1.03"}]}],"title":"C1D15: 4hr postdose (n= 1,1,1,1,1,0,1)"},{"categories":[{"measurements":[{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG000","spread":"NA","value":"0.53"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG001","spread":"NA","value":"45.97"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG002","spread":"NA","value":"77.62"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG003","spread":"NA","value":"36.06"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG004","spread":"NA","value":"30.08"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG005","spread":"NA","value":"NA"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG006","spread":"NA","value":"0.88"}]}],"title":"C1D15: 8hr postdose (n= 1,1,1,1,1,0,1)"},{"categories":[{"measurements":[{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG000","spread":"NA","value":"69.93"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG001","spread":"NA","value":"0.76"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG002","spread":"NA","value":"114.39"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG003","spread":"NA","value":"70.46"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG004","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG005","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG006","spread":"NA","value":"NA"}]}],"title":"C1D15: 24hr postdose (n= 1,1,1,1,0,0,0)"},{"categories":[{"measurements":[{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG000","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG001","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG002","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG003","spread":"NA","value":"NA"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG004","spread":"NA","value":"24.36"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG005","spread":"NA","value":"NA"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG006","spread":"NA","value":"0.98"}]}],"title":"C1D16: 24hr postdose (n= 0,0,0,0,1,0,1)"},{"categories":[{"measurements":[{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG000","spread":"NA","value":"68.48"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG001","spread":"NA","value":"90.02"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG002","spread":"NA","value":"125.77"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG003","spread":"NA","value":"82.06"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG004","spread":"NA","value":"30.58"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG005","spread":"NA","value":"NA"},{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG006","spread":"NA","value":"49.62"}]}],"title":"C1D19: pre-dose (n= 1,1,1,1,1,0,1)"},{"categories":[{"measurements":[{"comment":"Data for standard deviation was not estimable as only one subject analyzed.","groupId":"OG000","spread":"NA","value":"4.34"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG001","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG002","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG003","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG004","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG005","spread":"NA","value":"NA"},{"comment":"The parameter was not analyzed at specified time point because there were no subjects for which data was collected at the specified time point.","groupId":"OG006","spread":"NA","value":"NA"}]}],"title":"C1D19: 2hr postdose (n= 1,0,0,0,0,0,0)"}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"1"},{"groupId":"OG003","value":"1"},{"groupId":"OG004","value":"1"},{"groupId":"OG005","value":"3"},{"groupId":"OG006","value":"1"}],"units":"Participants"}],"description":"pS6 Concentrations in PBMCs was measured during DDI Evaluation period and Cycle 1 for DE cohorts. DDI evaluation period is a 4-day period that was performed within 1 week prior to Day 1 Cycle 1. In DDI evaluation period, On Day 1, SAR245409 was be administered alone, and on Day 3, Pimasertib was administered alone. No data were planned to be collected for \"Pimasertib (MSC1936369B) 60mg and SAR245409 30mg Twice Daily\", \"Pimasertib (MSC1936369B) 45mg and SAR245409 50mg Twice Daily\", \"Pimasertib (MSC1936369) 30mg and SAR245409 70mg Once Daily\" and \"Pimasertib (MSC1936369B) 60mg and SAR245409 90mg Once Daily\" reporting arms.","dispersionType":"Standard Deviation","groups":[{"description":"Pimasertib (MSC1936369B) capsule was administered at a single oral dose of 15 milligram (mg) along with single oral dose of 30 mg SAR245409 capsule on Day 1 of 21 days cycle until disease progression, intolerable toxicity, Investigator's decision to discontinue treatment, or withdrawal of consent by the subject.","id":"OG000","title":"Pimasertib (MSC1936369B) 15mg and SAR245409 30mg Once Daily"},{"description":"Pimasertib (MSC1936369B) capsule was administered at a single oral dose of 30 mg along with single oral dose of 30 mg SAR245409 capsule on Day 1 of 21 days cycle until disease progression, intolerable toxicity, Investigator's decision to discontinue treatment, or withdrawal of consent by the subject.","id":"OG001","title":"Pimasertib (MSC1936369B) 30mg and SAR245409 30mg Once Daily"},{"description":"Pimasertib (MSC1936369B) capsule was administered at a single oral dose of 15 mg along with single oral dose of 50 mg SAR245409 capsule on Day 1 of 21 days cycle until disease progression, intolerable toxicity, Investigator's decision to discontinue treatment, or withdrawal of consent by the subject.","id":"OG002","title":"Pimasertib (MSC1936369B) 15mg and SAR245409 50mg Once Daily"},{"description":"Pimasertib (MSC1936369B) capsule was administered at a single oral dose of 30 mg along with single oral dose of 50 mg SAR245409 capsule on Day 1 of each 21 days cycle until disease progression, intolerable toxicity, Investigator's decision to discontinue treatment, or withdrawal of consent by the subject.","id":"OG003","title":"Pimasertib (MSC1936369B) 30mg and SAR245409 50mg Once Daily"},{"description":"Pimasertib (MSC1936369B) capsule was administered at a single oral dose of 60 mg along with single oral dose of 50 mg SAR245409 capsule on Day 1 of 21 days cycle until disease progression, intolerable toxicity, Investigator's decision to discontinue treatment, or withdrawal of consent by the subject","id":"OG004","title":"Pimasertib (MSC1936369B) 60mg and SAR245409 50mg Once Daily"},{"description":"Pimasertib (MSC1936369B) capsule was administered at a single oral dose of 60 mg along with single oral dose of 70 mg SAR245409 capsule on Day 1 of 21 days cycle until disease progression, intolerable toxicity, Investigator's decision to discontinue treatment, or withdrawal of consent by the subject.","id":"OG005","title":"Pimasertib (MSC1936369B) 60mg and SAR245409 70mg Once Daily"},{"description":"Pimasertib (MSC1936369B) capsule was administered at a single oral dose of 90 mg along with single oral dose of 70 mg SAR245409 capsule on Day 1 of 21 days cycle until disease progression, intolerable toxicity, Investigator's decision to discontinue treatment, or withdrawal of consent by the subject.","id":"OG006","title":"Pimasertib (MSC1936369B) 90mg and SAR245409 70mg Once Daily"}],"paramType":"MEAN","populationDescription":"The Biomarker Analysis Set for pharmacodynamics (PD) marker analysis in PBMC included all subjects who received at least the first dose of both drugs and had provided at least one pre-dose sample and one post-dose sample. Here \"n\" signifies the number of subjects evaluable at the specific time points.","reportingStatus":"POSTED","timeFrame":"DDI Evaluation: Day 1 and 3 (predose, 2, 4, 8 and 24 hours (hr) postdose); Day 2 and 4 (24 hr postdose); Cycle 1 Day 1 (C1D1) and C1D15 (predose, 2, 4, 8, 24 hr postdose); C1D2 and C1D16 (24 hr postdose); C1D19 (predose, 2 hr postdose)","title":"pS6 Concentrations in Peripheral Blood Mononuclear Cells (PBMCs)","type":"SECONDARY","unitOfMeasure":"fluorescence intensity"}