{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"115.6","upperLimit":"316.3","value":"192.0"},{"groupId":"OG001","lowerLimit":"189.0","upperLimit":"462.6","value":"295.7"},{"groupId":"OG002","lowerLimit":"203.5","upperLimit":"324.3","value":"256.9"},{"groupId":"OG003","lowerLimit":"99.72","upperLimit":"505.2","value":"224.5"},{"groupId":"OG004","lowerLimit":"20.76","upperLimit":"816.5","value":"130.2"},{"groupId":"OG005","lowerLimit":"19.25","upperLimit":"214.2","value":"64.22"},{"groupId":"OG006","lowerLimit":"258.4","upperLimit":"405.2","value":"323.6"},{"groupId":"OG007","lowerLimit":"164.6","upperLimit":"351.6","value":"240.6"},{"groupId":"OG008","lowerLimit":"158.8","upperLimit":"361.4","value":"239.6"},{"groupId":"OG009","lowerLimit":"129.3","upperLimit":"349.4","value":"212.5"}]}],"title":"Day 1 (n=6, 11, 36, 3, 3, 4, 26, 23, 18, 15)"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"114.4","upperLimit":"349.1","value":"199.8"},{"groupId":"OG001","lowerLimit":"132.7","upperLimit":"378.4","value":"224.1"},{"groupId":"OG002","lowerLimit":"143.7","upperLimit":"345.7","value":"222.9"},{"comment":"Data was not estimable if evaluable subjects were less than 3 as per the planned decision because only 2 collected values were not sufficient to calculate a reliable estimation.","groupId":"OG003","lowerLimit":"NA","upperLimit":"NA","value":"NA"},{"comment":"Data was not estimable if evaluable subjects were less than 3 as per the planned decision because only 2 collected values were not sufficient to calculate a reliable estimation.","groupId":"OG004","lowerLimit":"NA","upperLimit":"NA","value":"NA"},{"groupId":"OG005","lowerLimit":"7.210","upperLimit":"1907","value":"117.2"},{"groupId":"OG006","lowerLimit":"256.4","upperLimit":"414.6","value":"326.0"},{"groupId":"OG007","lowerLimit":"144.6","upperLimit":"383.3","value":"235.5"},{"groupId":"OG008","lowerLimit":"82.31","upperLimit":"389.0","value":"178.9"},{"groupId":"OG009","lowerLimit":"143.9","upperLimit":"356.7","value":"226.6"}]}],"title":"Day 15 (n=6, 6, 25, 1, 1, 3, 17, 17, 10, 13)"}],"denoms":[{"counts":[{"groupId":"OG000","value":"6"},{"groupId":"OG001","value":"11"},{"groupId":"OG002","value":"36"},{"groupId":"OG003","value":"3"},{"groupId":"OG004","value":"3"},{"groupId":"OG005","value":"4"},{"groupId":"OG006","value":"26"},{"groupId":"OG007","value":"24"},{"groupId":"OG008","value":"18"},{"groupId":"OG009","value":"15"}],"units":"Participants"}],"dispersionType":"95% Confidence Interval","groups":[{"description":"SAR245409 capsule administered at a single oral dose of 30 milligram (mg) on Day 1 of 21 day cycle until disease progression, intolerable toxicity, Investigator's decision to discontinue treatment, or withdrawal of consent by the subject (DE Cohort).","id":"OG000","title":"SAR245409 30mg"},{"description":"SAR245409 capsule administered at a single oral dose of 50 mg on Day 1 of 21 day cycle until disease progression, intolerable toxicity, Investigator's decision to discontinue treatment, or withdrawal of consent by the subject (DE Cohort).","id":"OG001","title":"SAR245409 50mg"},{"description":"SAR245409 capsule administered at a single oral dose of 70 mg on Day 1 of 21 day cycle until disease progression, intolerable toxicity, Investigator's decision to discontinue treatment, or withdrawal of consent by the subject (DE Cohort).","id":"OG002","title":"SAR245409 70mg"},{"description":"SAR245409 capsule administered at a single oral dose of 90 mg on Day 1 of 21 day cycle until disease progression, intolerable toxicity, Investigator's decision to discontinue treatment, or withdrawal of consent by the subject (DE Cohort).","id":"OG003","title":"SAR245409 90mg"},{"description":"SAR245409 capsule administered twice, orally, at a dose of 30 mg on Day 1 of 21 day cycle until disease progression, intolerable toxicity, Investigator's decision to discontinue treatment, or withdrawal of consent by the subject (DE Cohort).","id":"OG004","title":"SAR245409 30mg Twice Daily"},{"description":"SAR245409 capsule administered twice, orally, at a dose of 50 mg on Day 1 of 21 day cycle until disease progression, intolerable toxicity, Investigator's decision to discontinue treatment, or withdrawal of consent by the subject (DE Cohort).","id":"OG005","title":"SAR245409 50mg Twice Daily"},{"description":"SAR245409 capsule administered at a single oral dose of 70 mg on Day 1 of 21 day cycle until disease progression, intolerable toxicity, Investigator's decision to discontinue treatment, or withdrawal of consent by the subject (DSE Cohort).","id":"OG006","title":"TNBC: SAR245409 70mg Once Daily"},{"description":"SAR245409 capsule administered at a single oral dose of 70 mg on Day 1 of 21 day cycle until disease progression, intolerable toxicity, Investigator's decision to discontinue treatment, or withdrawal of consent by the subject (DSE Cohort).","id":"OG007","title":"NSCLC: SAR245409 70mg Once"},{"description":"SAR245409 capsule administered at a single oral dose of 70 mg on Day 1 of 21 day cycle until disease progression, intolerable toxicity, Investigator's decision to discontinue treatment, or withdrawal of consent by the subject (DSE Cohort).","id":"OG008","title":"CRC: SAR245409 70mg Once Daily"},{"description":"SAR245409 capsule administered at a single oral dose of 70 mg on Day 1 of 21 day cycle until disease progression, intolerable toxicity, Investigator's decision to discontinue treatment, or withdrawal of consent by the subject (DSE Cohort).","id":"OG009","title":"MEL: SAR245409 70mg Once Daily"}],"paramType":"GEOMETRIC_MEAN","populationDescription":"The PK analysis set. Here \"n\" signifies the number of subjects evaluable at the specific time points.","reportingStatus":"POSTED","timeFrame":"Predose 0.5, 1, 1.5, 2, 3, 4, 8 and 24 hour post dose on Day 1, 15 for DSE Cohorts; Predose 0.5, 1, 1.5, 2, 3, 4, 8, 10 and 24 hour post dose on Day 1, 15 for DE cohorts","title":"Maximum Observed Plasma Concentration (Cmax) for SAR245409","type":"SECONDARY","unitOfMeasure":"nanogram per millilitre (ng/mL)"}