{"description":"Adverse event reporting is collected routinely using case report forms. The SAE table reflects NCI Common Terminology Criteria for Adverse Events (CTCAEs) submitted by the institution via expedited reporting (NCI AdEERs / CAeRs). All remaining CTCAEs collected by means other than expedited reporting are non-serious and are reported in the \"AE Other\" table. Ineligible patients are excluded from reporting of adverse events. All-Cause Mortality includes all deaths collected on the study.","eventGroups":[{"deathsNumAffected":198,"deathsNumAtRisk":559,"description":"INDUCTION (IND) 1Pts receive intrathecal (IT) cytarabine on day 1 and ADE with IV cytarabine over 1-30 minutes on days 1-10; daunorubicin hydrochloride IV over 1-15 minutes days1, 3, 5; etoposide IV 1-2 hours days1-5.\n\nIND IILow risk (LR) pts receive cytarabine IT and ADE chemotherapy as in INDI. High risk (HR) cytarabine IT day 1, MA chemo comprising high-dose cytarabine IV over 1-3 hours days1-4, mitoxantrone IV over 15-30 minutes days 3-6. INTENSIFICATION (INT) I: cytarabine IT day 1, AE chemo with high-dose cytarabine IV over 1-3 hours, etoposide IV over 1-2 hours days 1-5. INT II: LR-cytarabine IT day 1; Induction II MA chemo. HR and no SCT donor - high-dose cytarabine IV over 3 hours days1, 2, 8, 9; asparaginase intramuscularly (IM) days2,9.\n\nSCT:\n\n: pts receive fludarabine phosphate IV over 30 minutes once daily days -5 to -2, busulfan IV over 2 hours 4 times daily days -5 to -2.\n\nAllogeneic SCT within 36 to 48 hours after last busulfan dose. Pts receive GVHD prophylaxis.","id":"EG000","otherNumAffected":506,"otherNumAtRisk":559,"seriousNumAffected":82,"seriousNumAtRisk":559,"title":"Arm A"},{"deathsNumAffected":189,"deathsNumAtRisk":575,"description":"IND I: Pts receive cytarabine IT and ADE chemotherapy as in Induction I, Arm A. Patients also receive bortezomib IV over 3-5 seconds on days 1, 4, 8.\n\nIND II: LR pts receive cytarabine IT, ADE chemotherapy, bortezomib as in IND I. HR pts receive cytarabine IT, MA as in IND II, Arm A (HR patients) and bortezomib IV on days 1, 4, 8.\n\nINT I: Pts receive cytarabine IT and AE in Arm A, Intensification II, and bortezomib IV on days 1, 4, 8. INT II: LR pts receive cytarabine IT on day 1, MA as in Arm A, IND II (HR patients), and bortezomib IV on days 1, 4, 8. HR pts with no donor for SCT receive high-dose cytarabine IV over 3 hours on days 1, 2, 8, 9 and asparaginase intramuscularly (IM) on days 2 and 9.\n\nSCT - Pts receive fludarabine phosphate IV over 30 minutes once daily on days -5 to -2 and busulfan IV over 2 hours 4 times daily on days -5 to -2.Pts undergo allogeneic SCT within 36 to 48 hours after the last dose of busulfan. Pts receive GVHD prophylaxis.","id":"EG001","otherNumAffected":529,"otherNumAtRisk":575,"seriousNumAffected":305,"seriousNumAtRisk":575,"title":"Arm B"},{"deathsNumAffected":7,"deathsNumAtRisk":12,"description":"IND II: Pts receive cytarabine IT on day 1, cytarabine IV over 1-30 minutes on days 1-8, daunorubicin hydrochloride IV over 1-15 minutes on days 1, 3, and 5, etoposide IV over 1-2 hours on days 1-5, sorafenib tosylate PO on days 9-36.\n\nINT I: Pts receive cytarabine IT and AE chemotherapy in Arm A, Intensification II, and sorafenib tosylate PO on daily on days 6-28.\n\nINT II: Pts receive cytarabine IT on day 1, MA chemotherapy as in Arm A, Induction II (HR patients), sorafenib tosylate PO on days 7-34.\n\nSCT (HR patients with matched family \\[MFD\\] or unrelated donor):\n\nPts receive fludarabine phosphate IV over 30 minutes once daily on days -5 to -2, busulfan IV over 2 hours 4 times daily on days -5 to -2.\n\nPatients undergo allogeneic SCT within 36 to 48 hours after the last dose of busulfan. Pts receive GVHD prophylaxis.\n\nMAINTENANCE: Pts receive sorafenib tosylate PO starting day 40-100 after INT II or SCT for one year.","id":"EG002","otherNumAffected":12,"otherNumAtRisk":12,"seriousNumAffected":6,"seriousNumAtRisk":12,"title":"Arm C (Cohort 1)"},{"deathsNumAffected":11,"deathsNumAtRisk":33,"description":"IND I: Pts receive cytarabine IT \\& ADE as in Arm A, IND I \\& sorafenib tosylate PO at the time of known HR FLT3/ITD+ (including IND I \\& concurrently with chemo).\n\nIND II: Pts receive cytarabine IT day (d) 1, cytarabine IV over 1-30 minutes on d 1-8, daunorubicin hydrochloride IV over 1-15 minutes days 1, 3, 5, etoposide IV over 1-2 hours d 1-5, sorafenib tosylate PO d 9-36.\n\nINTE I: Pts receive cytarabine IT and AE in Arm A, INT II, and sorafenib tosylate PO on daily d 6-28.\n\nINT II: Pts receive cytarabine IT on d 1, MA as in Arm A, IND II (HR pts), sorafenib tosylate PO d 7-34.\n\nSCT (HR patients with matched family \\[MFD\\] or unrelated donor):\n\nPts receive fludarabine phosphate IV over 30 minutes once daily on d -5 to -2, busulfan IV over 2 hours 4 times daily d -5 to -2.\n\nPts undergo allogeneic SCT within 36-48 hours after last busulfan dose. Pts receive GVHD prophylaxis. MAINTENANCE: Pts receive sorafenib tosylate PO starting d 40-100 after INT II or SCT for 1 year.","id":"EG003","otherNumAffected":32,"otherNumAtRisk":33,"seriousNumAffected":16,"seriousNumAtRisk":33,"title":"Arm C (Cohort 2)"},{"deathsNumAffected":16,"deathsNumAtRisk":47,"description":"IND I: Pts receive cytarabine IT \\& ADE as in Arm A, IND I \\& sorafenib tosylate PO days 11-28.\n\nIND II: Pts receive cytarabine IT day 1, cytarabine IV over 1-30 minutes on days 1-8, daunorubicin hydrochloride IV over 1-15 minutes days 1, 3, 5, etoposide IV over 1-2 hours days 1-5, sorafenib tosylate PO days 9-36.\n\nINT I: Pts receive cytarabine IT \\& AE cin Arm A, INT II, \\& sorafenib tosylate PO daily days 6-28.\n\nINT II: Pts receive cytarabine IT day 1, MA as in Arm A, IND II (HR patients), \\& sorafenib tosylate PO days 7-34.\n\nSCT (HR patients with matched family \\[MFD\\] or unrelated donor):\n\nPts receive fludarabine phosphate IV over 30 minutes once daily on days -5 to -2 and busulfan IV over 2 hours 4 times daily days -5 to -2.\n\nPts undergo allogeneic SCT within 36 to 48 hours after last busulfan dose. Pts receive GVHD prophylaxis. MAINTENANCE: Pts receive sorafenib tosylate PO starting day 40-100 after INT II or SCT for 1 year.","id":"EG004","otherNumAffected":41,"otherNumAtRisk":47,"seriousNumAffected":30,"seriousNumAtRisk":47,"title":"Arm C (Cohort 3)"},{"deathsNumAffected":2,"deathsNumAtRisk":376,"description":"INDUCTION I: Patients with unknown FLT3/ITD status prior to study enrollment receive cytarabine IT and ADE chemotherapy as in Arm A, Induction I. If patients are determined to be HR FLT3/ITD+ no later than the end of Induction I they will be eligible to participate in Arm C.","id":"EG005","otherNumAffected":7,"otherNumAtRisk":376,"seriousNumAffected":2,"seriousNumAtRisk":376,"title":"Arm D"}],"frequencyThreshold":"0","otherEvents":[{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Adeers not subm","organSystem":"Blood and lymphatic system disorders","stats":[{"groupId":"EG000","numAffected":4,"numAtRisk":559},{"groupId":"EG001","numAffected":5,"numAtRisk":575},{"groupId":"EG002","numAffected":0,"numAtRisk":12},{"groupId":"EG003","numAffected":0,"numAtRisk":33},{"groupId":"EG004","numAffected":1,"numAtRisk":47},{"groupId":"EG005","numAffected":0,"numAtRisk":376}],"term":"Anemia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Adeers not subm","organSystem":"Blood and lymphatic system disorders","stats":[{"groupId":"EG000","numAffected":3,"numAtRisk":559},{"groupId":"EG001","numAffected":1,"numAtRisk":575},{"groupId":"EG002","numAffected":0,"numAtRisk":12},{"groupId":"EG003","numAffected":1,"numAtRisk":33},{"groupId":"EG004","numAffected":0,"numAtRisk":47},{"groupId":"EG005","numAffected":0,"numAtRisk":376}],"term":"Blood and lymphatic system disorders - Other, specify"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Adeers not subm","organSystem":"Blood and lymphatic system disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":559},{"groupId":"EG001","numAffected":0,"numAtRisk":575},{"groupId":"EG002","numAffected":0,"numAtRisk":12},{"groupId":"EG003","numAffected":0,"numAtRisk":33},{"groupId":"EG004","numAffected":0,"numAtRisk":47},{"groupId":"EG005","numAffected":0,"numAtRisk":376}],"term":"Bone marrow hypocellular"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Adeers not subm","organSystem":"Blood and lymphatic system disorders","stats":[{"groupId":"EG000","numAffected":3,"numAtRisk":559},{"groupId":"EG001","numAffected":3,"numAtRisk":575},{"groupId":"EG002","numAffected":0,"numAtRisk":12},{"groupId":"EG003","numAffected":1,"numAtRisk":33},{"groupId":"EG004","numAffected":0,"numAtRisk":47},{"groupId":"EG005","numAffected":0,"numAtRisk":376}],"term":"Disseminated intravascular coagulation"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Adeers not subm","organSystem":"Blood and lymphatic system disorders","stats":[{"groupId":"EG000","numAffected":212,"numAtRisk":559},{"groupId":"EG001","numAffected":175,"numAtRisk":575},{"groupId":"EG002","numAffected":6,"numAtRisk":12},{"groupId":"EG003","numAffected":8,"numAtRisk":33},{"groupId":"EG004","numAffected":12,"numAtRisk":47},{"groupId":"EG005","numAffected":2,"numAtRisk":376}],"term":"Febrile neutropenia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Adeers not subm","organSystem":"Blood and lymphatic system disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":559},{"groupId":"EG001","numAffected":0,"numAtRisk":575},{"groupId":"EG002","numAffected":0,"numAtRisk":12},{"groupId":"EG003","numAffected":0,"numAtRisk":33},{"groupId":"EG004","numAffected":0,"numAtRisk":47},{"groupId":"EG005","numAffected":0,"numAtRisk":376}],"term":"Leukocytosis"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Adeers not subm","organSystem":"Blood and lymphatic system disorders","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":559},{"groupId":"EG001","numAffected":1,"numAtRisk":575},{"groupId":"EG002","numAffected":0,"numAtRisk":12},{"groupId":"EG003","numAffected":0,"numAtRisk":33},{"groupId":"EG004","numAffected":0,"numAtRisk":47},{"groupId":"EG005","numAffected":0,"numAtRisk":376}],"term":"Lymph node pain"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Adeers not subm","organSystem":"Blood and lymphatic system disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":559},{"groupId":"EG001","numAffected":0,"numAtRisk":575},{"groupId":"EG002","numAffected":0,"numAtRisk":12},{"groupId":"EG003","numAffected":0,"numAtRisk":33},{"groupId":"EG004","numAffected":0,"numAtRisk":47},{"groupId":"EG005","numAffected":0,"numAtRisk":376}],"term":"Thrombotic thrombocytopenic purpura"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Adeers not subm","organSystem":"Cardiac disorders","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":559},{"groupId":"EG001","numAffected":1,"numAtRisk":575},{"groupId":"EG002","numAffected":0,"numAtRisk":12},{"groupId":"EG003","numAffected":0,"numAtRisk":33},{"groupId":"EG004","numAffected":0,"numAtRisk":47},{"groupId":"EG005","numAffected":0,"numAtRisk":376}],"term":"Asystole"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Adeers not subm","organSystem":"Cardiac disorders","stats":[{"groupId":"EG000","numAffected":4,"numAtRisk":559},{"groupId":"EG001","numAffected":2,"numAtRisk":575},{"groupId":"EG002","numAffected":0,"numAtRisk":12},{"groupId":"EG003","numAffected":0,"numAtRisk":33},{"groupId":"EG004","numAffected":0,"numAtRisk":47},{"groupId":"EG005","numAffected":0,"numAtRisk":376}],"term":"Cardiac arrest"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Adeers not subm","organSystem":"Cardiac disorders","stats":[{"groupId":"EG000","numAffected":8,"numAtRisk":559},{"groupId":"EG001","numAffected":16,"numAtRisk":575},{"groupId":"EG002","numAffected":0,"numAtRisk":12},{"groupId":"EG003","numAffected":0,"numAtRisk":33},{"groupId":"EG004","numAffected":1,"numAtRisk":47},{"groupId":"EG005","numAffected":0,"numAtRisk":376}],"term":"Cardiac disorders - Other, specify"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Adeers not subm","organSystem":"Cardiac disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":559},{"groupId":"EG001","numAffected":1,"numAtRisk":575},{"groupId":"EG002","numAffected":0,"numAtRisk":12},{"groupId":"EG003","numAffected":0,"numAtRisk":33},{"groupId":"EG004","numAffected":0,"numAtRisk":47},{"groupId":"EG005","numAffected":0,"numAtRisk":376}],"term":"Chest pain - cardiac"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Adeers not subm","organSystem":"Cardiac disorders","stats":[{"groupId":"EG000","numAffected":21,"numAtRisk":559},{"groupId":"EG001","numAffected":22,"numAtRisk":575},{"groupId":"EG002","numAffected":1,"numAtRisk":12},{"groupId":"EG003","numAffected":2,"numAtRisk":33},{"groupId":"EG004","numAffected":0,"numAtRisk":47},{"groupId":"EG005","numAffected":0,"numAtRisk":376}],"term":"Heart failure"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Adeers not subm","organSystem":"Cardiac disorders","stats":[{"groupId":"EG000","numAffected":30,"numAtRisk":559},{"groupId":"EG001","numAffected":28,"numAtRisk":575},{"groupId":"EG002","numAffected":1,"numAtRisk":12},{"groupId":"EG003","numAffected":1,"numAtRisk":33},{"groupId":"EG004","numAffected":0,"numAtRisk":47},{"groupId":"EG005","numAffected":0,"numAtRisk":376}],"term":"Left ventricular systolic dysfunction"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Adeers not subm","organSystem":"Cardiac disorders","stats":[{"groupId":"EG000","numAffected":4,"numAtRisk":559},{"groupId":"EG001","numAffected":3,"numAtRisk":575},{"groupId":"EG002","numAffected":0,"numAtRisk":12},{"groupId":"EG003","numAffected":0,"numAtRisk":33},{"groupId":"EG004","numAffected":0,"numAtRisk":47},{"groupId":"EG005","numAffected":0,"numAtRisk":376}],"term":"Pericardial effusion"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Adeers not subm","organSystem":"Cardiac disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":559},{"groupId":"EG001","numAffected":0,"numAtRisk":575},{"groupId":"EG002","numAffected":0,"numAtRisk":12},{"groupId":"EG003","numAffected":0,"numAtRisk":33},{"groupId":"EG004","numAffected":0,"numAtRisk":47},{"groupId":"EG005","numAffected":0,"numAtRisk":376}],"term":"Pulmonary valve disease"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Adeers not subm","organSystem":"Cardiac disorders","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":559},{"groupId":"EG001","numAffected":1,"numAtRisk":575},{"groupId":"EG002","numAffected":0,"numAtRisk":12},{"groupId":"EG003","numAffected":1,"numAtRisk":33},{"groupId":"EG004","numAffected":0,"numAtRisk":47},{"groupId":"EG005","numAffected":0,"numAtRisk":376}],"term":"Restrictive cardiomyopathy"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Adeers not subm","organSystem":"Cardiac disorders","stats":[{"groupId":"EG000","numAffected":3,"numAtRisk":559},{"groupId":"EG001","numAffected":0,"numAtRisk":575},{"groupId":"EG002","numAffected":0,"numAtRisk":12},{"groupId":"EG003","numAffected":0,"numAtRisk":33},{"groupId":"EG004","numAffected":0,"numAtRisk":47},{"groupId":"EG005","numAffected":0,"numAtRisk":376}],"term":"Right ventricular dysfunction"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Adeers not subm","organSystem":"Cardiac disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":559},{"groupId":"EG001","numAffected":3,"numAtRisk":575},{"groupId":"EG002","numAffected":0,"numAtRisk":12},{"groupId":"EG003","numAffected":0,"numAtRisk":33},{"groupId":"EG004","numAffected":0,"numAtRisk":47},{"groupId":"EG005","numAffected":0,"numAtRisk":376}],"term":"Sinus bradycardia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Adeers not subm","organSystem":"Cardiac disorders","stats":[{"groupId":"EG000","numAffected":13,"numAtRisk":559},{"groupId":"EG001","numAffected":7,"numAtRisk":575},{"groupId":"EG002","numAffected":0,"numAtRisk":12},{"groupId":"EG003","numAffected":0,"numAtRisk":33},{"groupId":"EG004","numAffected":0,"numAtRisk":47},{"groupId":"EG005","numAffected":0,"numAtRisk":376}],"term":"Sinus tachycardia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Adeers not subm","organSystem":"Cardiac disorders","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":559},{"groupId":"EG001","numAffected":1,"numAtRisk":575},{"groupId":"EG002","numAffected":0,"numAtRisk":12},{"groupId":"EG003","numAffected":0,"numAtRisk":33},{"groupId":"EG004","numAffected":0,"numAtRisk":47},{"groupId":"EG005","numAffected":0,"numAtRisk":376}],"term":"Supraventricular tachycardia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Adeers not subm","organSystem":"Cardiac disorders","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":559},{"groupId":"EG001","numAffected":1,"numAtRisk":575},{"groupId":"EG002","numAffected":0,"numAtRisk":12},{"groupId":"EG003","numAffected":0,"numAtRisk":33},{"groupId":"EG004","numAffected":0,"numAtRisk":47},{"groupId":"EG005","numAffected":0,"numAtRisk":376}],"term":"Tricuspid valve disease"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Adeers not subm","organSystem":"Cardiac disorders","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":559},{"groupId":"EG001","numAffected":0,"numAtRisk":575},{"groupId":"EG002","numAffected":0,"numAtRisk":12},{"groupId":"EG003","numAffected":0,"numAtRisk":33},{"groupId":"EG004","numAffected":0,"numAtRisk":47},{"groupId":"EG005","numAffected":0,"numAtRisk":376}],"term":"Ventricular arrhythmia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Adeers not subm","organSystem":"Cardiac disorders","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":559},{"groupId":"EG001","numAffected":1,"numAtRisk":575},{"groupId":"EG002","numAffected":0,"numAtRisk":12},{"groupId":"EG003","numAffected":0,"numAtRisk":33},{"groupId":"EG004","numAffected":0,"numAtRisk":47},{"groupId":"EG005","numAffected":0,"numAtRisk":376}],"term":"Ventricular fibrillation"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Adeers not subm","organSystem":"Cardiac disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":559},{"groupId":"EG001","numAffected":1,"numAtRisk":575},{"groupId":"EG002","numAffected":0,"numAtRisk":12},{"groupId":"EG003","numAffected":0,"numAtRisk":33},{"groupId":"EG004","numAffected":0,"numAtRisk":47},{"groupId":"EG005","numAffected":0,"numAtRisk":376}],"term":"Ventricular tachycardia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Adeers not subm","organSystem":"Congenital, familial and genetic disorders","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":559},{"groupId":"EG001","numAffected":0,"numAtRisk":575},{"groupId":"EG002","numAffected":0,"numAtRisk":12},{"groupId":"EG003","numAffected":1,"numAtRisk":33},{"groupId":"EG004","numAffected":0,"numAtRisk":47},{"groupId":"EG005","numAffected":0,"numAtRisk":376}],"term":"Congenital, familial and genetic disorders - Other, specify"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Adeers not subm","organSystem":"Ear and labyrinth disorders","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":559},{"groupId":"EG001","numAffected":1,"numAtRisk":575},{"groupId":"EG002","numAffected":0,"numAtRisk":12},{"groupId":"EG003","numAffected":0,"numAtRisk":33},{"groupId":"EG004","numAffected":0,"numAtRisk":47},{"groupId":"EG005","numAffected":0,"numAtRisk":376}],"term":"Hearing impaired"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Adeers not subm","organSystem":"Endocrine disorders","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":559},{"groupId":"EG001","numAffected":1,"numAtRisk":575},{"groupId":"EG002","numAffected":0,"numAtRisk":12},{"groupId":"EG003","numAffected":0,"numAtRisk":33},{"groupId":"EG004","numAffected":0,"numAtRisk":47},{"groupId":"EG005","numAffected":0,"numAtRisk":376}],"term":"Adrenal insufficiency"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Adeers not subm","organSystem":"Endocrine disorders","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":559},{"groupId":"EG001","numAffected":0,"numAtRisk":575},{"groupId":"EG002","numAffected":1,"numAtRisk":12},{"groupId":"EG003","numAffected":0,"numAtRisk":33},{"groupId":"EG004","numAffected":0,"numAtRisk":47},{"groupId":"EG005","numAffected":0,"numAtRisk":376}],"term":"Endocrine disorders - Other, specify"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Adeers not subm","organSystem":"Eye disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":559},{"groupId":"EG001","numAffected":0,"numAtRisk":575},{"groupId":"EG002","numAffected":0,"numAtRisk":12},{"groupId":"EG003","numAffected":0,"numAtRisk":33},{"groupId":"EG004","numAffected":0,"numAtRisk":47},{"groupId":"EG005","numAffected":0,"numAtRisk":376}],"term":"Blurred vision"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Adeers not subm","organSystem":"Eye disorders","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":559},{"groupId":"EG001","numAffected":2,"numAtRisk":575},{"groupId":"EG002","numAffected":0,"numAtRisk":12},{"groupId":"EG003","numAffected":0,"numAtRisk":33},{"groupId":"EG004","numAffected":0,"numAtRisk":47},{"groupId":"EG005","numAffected":0,"numAtRisk":376}],"term":"Eye disorders - Other, specify"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Adeers not subm","organSystem":"Eye disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":559},{"groupId":"EG001","numAffected":0,"numAtRisk":575},{"groupId":"EG002","numAffected":0,"numAtRisk":12},{"groupId":"EG003","numAffected":0,"numAtRisk":33},{"groupId":"EG004","numAffected":0,"numAtRisk":47},{"groupId":"EG005","numAffected":0,"numAtRisk":376}],"term":"Eye pain"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Adeers not subm","organSystem":"Eye disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":559},{"groupId":"EG001","numAffected":0,"numAtRisk":575},{"groupId":"EG002","numAffected":0,"numAtRisk":12},{"groupId":"EG003","numAffected":0,"numAtRisk":33},{"groupId":"EG004","numAffected":0,"numAtRisk":47},{"groupId":"EG005","numAffected":0,"numAtRisk":376}],"term":"Periorbital edema"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Adeers not subm","organSystem":"Eye disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":559},{"groupId":"EG001","numAffected":0,"numAtRisk":575},{"groupId":"EG002","numAffected":0,"numAtRisk":12},{"groupId":"EG003","numAffected":0,"numAtRisk":33},{"groupId":"EG004","numAffected":0,"numAtRisk":47},{"groupId":"EG005","numAffected":0,"numAtRisk":376}],"term":"Vitreous hemorrhage"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Adeers not subm","organSystem":"Gastrointestinal disorders","stats":[{"groupId":"EG000","numAffected":3,"numAtRisk":559},{"groupId":"EG001","numAffected":0,"numAtRisk":575},{"groupId":"EG002","numAffected":0,"numAtRisk":12},{"groupId":"EG003","numAffected":0,"numAtRisk":33},{"groupId":"EG004","numAffected":0,"numAtRisk":47},{"groupId":"EG005","numAffected":0,"numAtRisk":376}],"term":"Abdominal distension"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Adeers not subm","organSystem":"Gastrointestinal 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