{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"41.2","upperLimit":"57.0","value":"49.1"},{"groupId":"OG001","lowerLimit":"53.8","upperLimit":"75.2","value":"65.1"},{"groupId":"OG002","lowerLimit":"48.0","upperLimit":"60.8","value":"54.5"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"163"},{"groupId":"OG001","value":"83"},{"groupId":"OG002","value":"246"}],"units":"Participants"}],"description":"Overall response rate (ORR) was defined as the percentage of participants with a best overall complete response (CR) or partial response (PR) per RECIST 1.0. Per Response Evaluation Criteria In Solid Tumors Criteria (RECIST v1.0) for target lesions and assessed by MRI, CR was the disappearance of all target lesions. PR was at least a 30% decrease in the sum of the longest diameter of all target lesions, taking as reference the baseline sum of the longest diameters. Both CR and PR had to be confirmed by repeat assessments performed no less than 4 weeks after the criteria for response were first met. CR = at least two determinations of CR, at least 4 weeks apart before progression. PR = at least two determinations of PR or better at least 4 weeks apart before progression (and not qualifying for a CR).","dispersionType":"95% Confidence Interval","groups":[{"description":"Patients with ALK-translocated NSCLC who were previously treated with an ALK inhibitor.","id":"OG000","title":"NSCLC With Prior ALKi (Arms 1A + 1B)"},{"description":"Patients with ALK-translocated NSCLC not previously treated with an ALK inhibitor.","id":"OG001","title":"NSCLC ALKi Naive (Arm 2)"},{"description":"all NSCLC patients.","id":"OG002","title":"All NCSLC"}],"paramType":"NUMBER","populationDescription":"Full analysis set (FAS) - NSCLC: Subset of Full Analysis Set including ALK-positive NSCLC patients who received at least one dose of LDK378 in the 750 mg dose group.","reportingStatus":"POSTED","timeFrame":"275 weeks","title":"Overall Response Rate Based on Blinded Independent Review Committee (BIRC) Assessment","type":"SECONDARY","unitOfMeasure":"Percentage of participants"}