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12"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1421","upperLimit":"6528","value":"2386.6"},{"groupId":"OG001","lowerLimit":"1253","upperLimit":"5026","value":"2451.7"}]}],"title":"GSK2298683, Week 32, predose, n=11, 7"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"5323","upperLimit":"17129","value":"11225.8"},{"groupId":"OG001","lowerLimit":"4578","upperLimit":"8786","value":"6547.4"}]}],"title":"GSK2298683, Week 32, 4-8 hrs, n=2, 8"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"50","upperLimit":"1338","value":"317.9"},{"groupId":"OG001","lowerLimit":"3","upperLimit":"2690","value":"323.0"}]}],"title":"GSK2167542, Week 4, predose, n=55, 58"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"62","upperLimit":"1505","value":"351.6"},{"groupId":"OG001","lowerLimit":"46","upperLimit":"1619","value":"332.1"}]}],"title":"GSK2167542, Week 4, 1-3 hrs, n=63, 70"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"86","upperLimit":"964","value":"324.1"},{"groupId":"OG001","lowerLimit":"56","upperLimit":"1272","value":"298.6"}]}],"title":"GSK2167542, Week 8, predose, n=36, 36"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"91","upperLimit":"899","value":"305.4"},{"groupId":"OG001","lowerLimit":"78","upperLimit":"960","value":"320.5"}]}],"title":"GSK2167542, Week 8, 4-8 hrs, n=19, 25"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"93","upperLimit":"1095","value":"285.5"},{"groupId":"OG001","lowerLimit":"35","upperLimit":"1200","value":"310.8"}]}],"title":"GSK2167542, Week 16, predose, n=26, 23"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"69","upperLimit":"769","value":"291.1"},{"groupId":"OG001","lowerLimit":"81","upperLimit":"652","value":"320.5"}]}],"title":"GSK2167542, Week 16, 4-8 hrs, n=11, 18"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"94","upperLimit":"875","value":"304.0"},{"groupId":"OG001","lowerLimit":"63","upperLimit":"795","value":"334.0"}]}],"title":"GSK2167542, Week 24, predose, n=14, 10"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"19","upperLimit":"401","value":"190.7"},{"groupId":"OG001","lowerLimit":"106","upperLimit":"599","value":"287.9"}]}],"title":"GSK2167542, Week 24, 4-8 hrs, n=5, 12"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"113","upperLimit":"960","value":"361.2"},{"groupId":"OG001","lowerLimit":"69","upperLimit":"690","value":"316.3"}]}],"title":"GSK2167542, Week 32, predose, n=11, 2"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"225","upperLimit":"231","value":"227.8"},{"groupId":"OG001","lowerLimit":"231","upperLimit":"1021","value":"273.9"}]}],"title":"GSK2167542, Week 32, 4-8 hrs, n=2, 8"}],"denoms":[{"counts":[{"groupId":"OG000","value":"75"},{"groupId":"OG001","value":"77"}],"units":"Participants"}],"description":"Summary statistics were calculated for each time point by cohort. The population pharmacokinetics were determined using a non-linear mixed effects modeling approach after pooling the data with other studies. These results are reported separately.","dispersionType":"Full Range","groups":[{"description":"Participants who received no prior local therapy for brain metastasis received GSK2118436 150 mg capsules either one hour before or 2 hours after a meal twice daily until evidence of disease progression, death, or unacceptable adverse events.","id":"OG000","title":"GSK2118436 150 mg: No Prior Local Therapy"},{"description":"Participants who received prior local therapy for brain metastasis received GSK2118436 150 mg capsules either one hour before or 2 hours after a meal twice daily until evidence of disease progression, death, or unacceptable adverse events.","id":"OG001","title":"GSK2118436 150 mg: Prior Local Therapy"}],"paramType":"MEDIAN","populationDescription":"PK Population: participants in the ATS population for whom a PK sample was obtained and analyzed. Only those participants whose samples were available at the indicated time points were analyzed.","reportingStatus":"POSTED","timeFrame":"Week 4 (pre-dose and 1-3 hours post-dose) and Weeks 8, 16, 24, and 32 (either pre-dose in the morning or in the afternoon at 4-8 hours post-dose)","title":"Median Concentrations of GSK2118436 and Its Metabolites Including GSK2285403, GSK2298683, and GSK2167542","type":"SECONDARY","unitOfMeasure":"nanograms per milliliter (ng/mL)"}