{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","value":"71"}]}],"title":"Glucose (hyperglycemia), AGI, n=165"},{"categories":[{"measurements":[{"groupId":"OG000","value":"8"}]}],"title":"Glucose (hyperglycemia), Increase to G 3, n=165"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"}]}],"title":"Glucose (hyperglycemia), Increase to G 4, n=165"},{"categories":[{"measurements":[{"groupId":"OG000","value":"24"}]}],"title":"Glucose (hypoglycemia), AGI, n=165"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Glucose (hypoglycemia), Increase to G 3, n=165"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Glucose (hypoglycemia), Increase to G 4, n=165"},{"categories":[{"measurements":[{"groupId":"OG000","value":"2"}]}],"title":"Magnesium (hypermagnesemia) AGI, n=165"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Magnesium (hypermagnesemia), Increase to G 3,n=165"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Magnesium (hypermagnesemia), Increase to G 4,n=165"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Magnesium (hypomagnesemia), AGI, n=165"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Magnesium (hypomagnesemia), Increase to G 3, n=165"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Magnesium (hypomagnesemia), Increase to G 4, n=165"},{"categories":[{"measurements":[{"groupId":"OG000","value":"8"}]}],"title":"Sodium (hypernatremia), AGI, n=165"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Sodium (hypernatremia), Increase to G 3, n=165"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Sodium (hypernatremia), Increase to G 4, n=165"},{"categories":[{"measurements":[{"groupId":"OG000","value":"21"}]}],"title":"Sodium (hyponatremia), AGI, n=165"},{"categories":[{"measurements":[{"groupId":"OG000","value":"3"}]}],"title":"Sodium (hyponatremia), Increase to G 3, n=165"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Sodium (hyponatremia), Increase to G. 4, n=165"},{"categories":[{"measurements":[{"groupId":"OG000","value":"53"}]}],"title":"Phosphorus inorganic, AGI, n=165"},{"categories":[{"measurements":[{"groupId":"OG000","value":"13"}]}],"title":"Phosphorus inorganic, Increase to G 3, n=165"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Phosphorus inorganic, Increase to G 4, n=165"},{"categories":[{"measurements":[{"groupId":"OG000","value":"8"}]}],"title":"Potassium (hyperkalemia), AGI, n=165"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Potassium (hyperkalemia), Increase to G 3, n=165"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Potassium (hyperkalemia), Increase to G 4, n=165"},{"categories":[{"measurements":[{"groupId":"OG000","value":"17"}]}],"title":"Potassium (hypokalemia), AGI, n=165"},{"categories":[{"measurements":[{"groupId":"OG000","value":"4"}]}],"title":"Potassium (hypokalemia), Increase to G 3, n=165"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Potassium (hypokalemia), Increase to G 4, n=165"},{"categories":[{"measurements":[{"groupId":"OG000","value":"41"}]}],"title":"ALP, AGI, n=165"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"}]}],"title":"ALP, Increase to G 3, n=165"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"ALP, Increase to G 4, n=165"},{"categories":[{"measurements":[{"groupId":"OG000","value":"26"}]}],"title":"AST, AGI, n=165"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"}]}],"title":"AST, Increase to G 3, n=165"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"AST, Increase to G 4, n=165"},{"categories":[{"measurements":[{"groupId":"OG000","value":"27"}]}],"title":"ALT, AGI, n=165"},{"categories":[{"measurements":[{"groupId":"OG000","value":"2"}]}],"title":"ALT, Increase to G 3, n=165"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"ALT, Increase to G 4, n=165"},{"categories":[{"measurements":[{"groupId":"OG000","value":"10"}]}],"title":"Creatinine, AGI, n=165"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Creatinine, Increase to G 3, n=165"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Creatinine, Increase to G 4, n=165"},{"categories":[{"measurements":[{"groupId":"OG000","value":"5"}]}],"title":"Total bilirubin, AGI, n=163"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Total bilirubin, Increase to G 3 n=163"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Total bilirubin, Increase to G 4 n=163"},{"categories":[{"measurements":[{"groupId":"OG000","value":"9"}]}],"title":"Albumin, AGI, n=27"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Albumin, Increase to G 3, n=27"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Albumin, Increase to G 4, n=27"},{"categories":[{"measurements":[{"groupId":"OG000","value":"3"}]}],"title":"Amylase, AGI, n=16"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"}]}],"title":"Amylase, Increase to G 3, n=16"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"}]}],"title":"Amylase, Increase to G 4, n=16"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"}]}],"title":"Cholesterol, AGI, n=2"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Cholesterol, Increase to G 3, n=2"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Cholesterol, Increase to G 4, n=2"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"}]}],"title":"Creatine kinase, AGI, n=6"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Creatine kinase, Increase to G 3, n=6"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"}]}],"title":"Creatine kinase, Increase to G 4, n=6"},{"categories":[{"measurements":[{"groupId":"OG000","value":"13"}]}],"title":"GGT, AGI, n=22"},{"categories":[{"measurements":[{"groupId":"OG000","value":"4"}]}],"title":"GGT, Increase to G 3, n=22"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"GGT, Increase to G 4, n=22"},{"categories":[{"measurements":[{"groupId":"OG000","value":"10"}]}],"title":"Lipase, AGI, n=19"},{"categories":[{"measurements":[{"groupId":"OG000","value":"4"}]}],"title":"Lipase, Increase to G 3, n=19"},{"categories":[{"measurements":[{"groupId":"OG000","value":"2"}]}],"title":"Lipase, Increase to G 4, n=19"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Blood pH, AGI, n=1"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Blood pH, Increase to G 3, n=1"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Blood pH, Increase to G 4, n=1"},{"categories":[{"measurements":[{"groupId":"OG000","value":"3"}]}],"title":"Triglycerides, AGI, n=5"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Triglycerides, Increase to G 3, n=5"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Triglycerides, Increase to G 4, n=5"}],"denoms":[{"counts":[{"groupId":"OG000","value":"165"}],"units":"Participants"}],"description":"Clinical chemistry data were summarized at each scheduled assessment according to National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE, version 4.0). Grade refers to the severity of the toxicity. The CTCAE displays Grades 1 through 5 with unique clinical descriptions of severity for each toxicity based on this general guideline: Grade (G) 1, mild; Grade 2, moderate; Grade 3, severe; Grade 4, life threatening; Grade 5, death related to toxicity. Blood sample was collected for the assessment of glucose, potassium, magnesium, sodium, phosphorus, potassium. aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), creatinine, total bilirubin, albumin, amylase, cholesterol, creatine kinase, gamma glutamyl transferase (GGT), lipase, blood pH, and triglycerides.","groups":[{"description":"Participants with or without prior local therapy for brain metastasis received GSK2118436 50 mg and 75 mg capsules either one hour before or 2 hours after a meal twice daily.","id":"OG000","title":"GSK2118436 150 mg"}],"paramType":"NUMBER","populationDescription":"ATS Population. Only those participants with data available for the indicated parameters were analyzed.","reportingStatus":"POSTED","timeFrame":"From Screening until the conclusion of the study (up to 103 weeks)","title":"Number of Participants With a Worst-case on Therapy Change to Grade 3 and Grade 4, or With Any Grade Increase (AGI), From Baseline Grade for Clinical Chemistry Parameters","type":"SECONDARY","unitOfMeasure":"participants"}