{"analyses":[{"groupIds":["OG000","OG001","OG002"],"nonInferiorityComment":"Other, trend test.","nonInferiorityType":"OTHER","pValue":"0.15","pValueComment":"The reported p-value is representative of the difference in levels of Kep between MGUS and SMM+MM.","statisticalMethod":"Jonckheere-Terpstra test for trend"},{"groupIds":["OG000","OG001","OG002"],"nonInferiorityComment":"Other, trend test.","nonInferiorityType":"OTHER","pValue":"0.33","pValueComment":"The reported p-value is representative of the difference in levels of Ktrans between MGUS and SMM+MM.","statisticalMethod":"Jonckheere-Terpstra test for trend"}],"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1.6","upperLimit":"9.2","value":"3.9"},{"groupId":"OG001","lowerLimit":"0.7","upperLimit":"12.2","value":"9"},{"groupId":"OG002","lowerLimit":"2.1","upperLimit":"12.7","value":"5.8"}]}],"title":"Kep"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1","upperLimit":"4.2","value":"2.4"},{"groupId":"OG001","lowerLimit":"0.4","upperLimit":"4.4","value":"2.3"},{"groupId":"OG002","lowerLimit":"1.6","upperLimit":"4.1","value":"3.1"}]}],"title":"Ktrans"}],"denoms":[{"counts":[{"groupId":"OG000","value":"10"},{"groupId":"OG001","value":"10"},{"groupId":"OG002","value":"7"}],"units":"Participants"}],"description":"Pharmacokinetic parameters Kep and Ktrans were measured by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI).","dispersionType":"Full Range","groups":[{"description":"MGUS (Monoclonal gammopathy of undetermined significance) is a premalignant plasma cell proliferative disorder.","id":"OG000","title":"MGUS (Monoclonal Gammopathy of Undetermined Significance)"},{"description":"Smoldering multiple myeloma (SMM)is a premalignant plasma cell proliferative disorder.","id":"OG001","title":"SMM (Smoldering Multiple Myeloma)"},{"description":"Multiple myeloma is a plasma cell neoplasm.","id":"OG002","title":"MM (Multiple Myeloma)"}],"paramType":"MEDIAN","populationDescription":"Three patients with MM did not undergo bone marrow biopsies and were not included in this analysis.","reportingStatus":"POSTED","timeFrame":"60 days","title":"Comparison of Reverse Contrast Transfer Rate (Kep) and Forward Contrast Transfer Rate (Ktrans) Among Patients With MGUS, SMM, and MM","type":"SECONDARY","unitOfMeasure":"per min"}