{"analyses":[{"groupIds":["OG000","OG001"],"nonInferiorityType":"SUPERIORITY","pValue":"0.024","pValueComment":"The reported p-value is representative of the difference in levels of Ang2 in both groups.","statisticalMethod":"Wilcoxon rank sum test"},{"groupIds":["OG000","OG001"],"nonInferiorityType":"SUPERIORITY","pValue":"0.055","pValueComment":"The reported p-value is representative of the difference in levels of G-CSF in both groups.","statisticalMethod":"Wilcoxon rank sum test"},{"groupIds":["OG000","OG001"],"nonInferiorityType":"SUPERIORITY","pValue":"0.055","pValueComment":"The reported p-value is representative of the difference in levels of Follistatin in both groups.","statisticalMethod":"Wilcoxon rank sum test"},{"groupIds":["OG000","OG001"],"nonInferiorityType":"SUPERIORITY","pValue":"0.0098","pValueComment":"The reported p-value is representative of the difference in levels of HGF in both groups.","statisticalMethod":"Wilcoxon rank sum test"},{"groupIds":["OG000","OG001"],"nonInferiorityType":"SUPERIORITY","pValue":"0.02","pValueComment":"The reported p-value is representative of the difference in levels of VEGF-A in both groups.","statisticalMethod":"Wilcoxon rank sum test"}],"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"589.27","value":"2465.97"},{"groupId":"OG001","spread":"467.16","value":"3804.42"}]}],"title":"Ang2 (angiopoietin)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"11.66","value":"24.92"},{"groupId":"OG001","spread":"42.81","value":"101.08"}]}],"title":"G-CSF (granulocyte-colony stimulating factor)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"88.89","value":"562.45"},{"groupId":"OG001","spread":"83.00","value":"823.15"}]}],"title":"Follistatin"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"70.82","value":"390.57"},{"groupId":"OG001","spread":"57.97","value":"654.34"}]}],"title":"HGF (hepatocyte growth factor)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"435.94","value":"844.31"},{"groupId":"OG001","spread":"196.47","value":"1301.52"}]}],"title":"VEGF-A (vascular endothelial growth factor-A)"},{"categories":[{"measurements":[{"comment":"Serum measures of FGF-1 were below the range of detectability, so these markers were excluded from analysis.","groupId":"OG000","spread":"NA","value":"NA"},{"comment":"Serum measures of FGF-1 were below the range of detectability, so these markers were excluded from analysis.","groupId":"OG001","spread":"NA","value":"NA"}]}],"title":"FGF-1 (fibroblast growth factor 1)"},{"categories":[{"measurements":[{"comment":"Serum measures of endothelin-1 were below the range of detectability, so these markers were excluded from analysis.","groupId":"OG000","spread":"NA","value":"NA"},{"comment":"Serum measures of endothelin-1 were below the range of detectability, so these markers were excluded from analysis.","groupId":"OG001","spread":"NA","value":"NA"}]}],"title":"Endothelin 1"}],"denoms":[{"counts":[{"groupId":"OG000","value":"10"},{"groupId":"OG001","value":"17"}],"units":"Participants"}],"description":"The assay was performed according to the manufacture's protocol, and all samples were diluted 1:3. Cytokine values were calculated using a five-parameter standard curve with Bio-Plex Manager 6.1.","dispersionType":"Standard Error","groups":[{"description":"MGUS (Monoclonal gammopathy of undetermined significance) is a premalignant plasma cell proliferative disorder.","id":"OG000","title":"MGUS (Monoclonal Gammopathy of Undetermined Significance)"},{"description":"Smoldering multiple myeloma (SMM)is a premalignant plasma cell proliferative disorder. Multiple myeloma is a plasma cell neoplasm.","id":"OG001","title":"SMM (Smoldering Multiple Myeloma)/MM (Multiple Myeloma)"}],"paramType":"MEAN","populationDescription":"Serum was not available for three patients in the SMM group.","reportingStatus":"POSTED","timeFrame":"60 days","title":"Comparison of Serum Angiogenic Markers Ang2 (Angiopoietin), G-CSF (Granulocyte-colony Stimulating Factor), Follistatin, HGF (Hepatocyte Growth Factor), FGF-1, Endothelin 1, and VEGF-A (Vascular Endothelial Growth Factor-A) Between MGUS and SMM/MM Groups","type":"SECONDARY","unitOfMeasure":"pg/ml"}