{"analyses":[{"ciLowerLimit":"1.81","ciNumSides":"TWO_SIDED","ciPctValue":"95","ciUpperLimit":"220.5","estimateComment":"Comparison: \"Tertile 1 (with 2 year lag)\" and \"Never (with 2 year lag)\".","groupIds":["OG000","OG001"],"nonInferiorityType":"SUPERIORITY_OR_OTHER","pValue":"0.0144","paramType":"Odds Ratio (OR)","paramValue":"20.00","statisticalMethod":"Conditional Logistic Regression"},{"ciLowerLimit":"1.78","ciNumSides":"TWO_SIDED","ciPctValue":"95","ciUpperLimit":"258.8","estimateComment":"Comparison: \"Tertile 1 (with 2 year lag)\" and \"Never (with 2 year lag)\". Adjusted for smoking, BMI, diabetes, neuropathic pain, back pain, epilepsy, HIV, HPV (genital).","groupIds":["OG000","OG001"],"nonInferiorityType":"SUPERIORITY_OR_OTHER","pValue":"0.0158","paramType":"Odds Ratio (OR)","paramValue":"21.47","statisticalMethod":"Conditional Logistic Regression"},{"ciLowerLimit":"0.99","ciNumSides":"TWO_SIDED","ciPctValue":"95","ciUpperLimit":"15.14","estimateComment":"Comparison: \"Tertile 1 (without 2 year lag)\" and \"Never (without 2 year lag)\".","groupIds":["OG000","OG001"],"nonInferiorityType":"SUPERIORITY_OR_OTHER","pValue":"0.0524","paramType":"Odds Ratio (OR)","paramValue":"3.86","statisticalMethod":"Conditional Logistic Regression"},{"ciLowerLimit":"1.21","ciNumSides":"TWO_SIDED","ciPctValue":"95","ciUpperLimit":"22.51","estimateComment":"Comparison: \"Tertile 1 (without 2 year lag)\" and \"Never (without 2 year lag)\". Adjusted for smoking, BMI, diabetes, neuropathic pain, back pain, epilepsy, HIV, HPV (genital).","groupIds":["OG000","OG001"],"nonInferiorityType":"SUPERIORITY_OR_OTHER","pValue":"0.0269","paramType":"Odds Ratio (OR)","paramValue":"5.21","statisticalMethod":"Conditional Logistic Regression"},{"ciLowerLimit":"0.45","ciNumSides":"TWO_SIDED","ciPctValue":"95","ciUpperLimit":"55.14","estimateComment":"Comparison: \"Tertile 2 (with 2 year lag)\" and \"Never (with 2 year lag)\".","groupIds":["OG000","OG001"],"nonInferiorityType":"SUPERIORITY_OR_OTHER","pValue":"0.1888","paramType":"Odds Ratio (OR)","paramValue":"5.00","statisticalMethod":"Conditional Logistic Regression"},{"ciLowerLimit":"0.03","ciNumSides":"TWO_SIDED","ciPctValue":"95","ciUpperLimit":"32.21","estimateComment":"Comparison: \"Tertile 2 (with 2 year lag)\" and \"Never (with 2 year lag)\". Adjusted for smoking, BMI, diabetes, neuropathic pain, back pain, epilepsy, HIV, HPV (genital).","groupIds":["OG000","OG001"],"nonInferiorityType":"SUPERIORITY_OR_OTHER","pValue":"0.9990","paramType":"Odds Ratio (OR)","paramValue":"1.00","statisticalMethod":"Conditional Logistic Regression"},{"ciLowerLimit":"0.33","ciNumSides":"TWO_SIDED","ciPctValue":"95","ciUpperLimit":"43.08","estimateComment":"Comparison: \"Tertile 3 (with 2 year lag)\" and \"Never (with 2 year lag)\".","groupIds":["OG000","OG001"],"nonInferiorityType":"SUPERIORITY_OR_OTHER","pValue":"0.2885","paramType":"Odds Ratio (OR)","paramValue":"3.75","statisticalMethod":"Conditional Logistic Regression"},{"ciLowerLimit":"0.06","ciNumSides":"TWO_SIDED","ciPctValue":"95","ciUpperLimit":"13.87","estimateComment":"Comparison: \"Tertile 3 (with 2 year lag)\" and \"Never (with 2 year lag)\". Adjusted for smoking, BMI, diabetes, neuropathic pain, back pain, epilepsy, HIV, HPV (genital).","groupIds":["OG000","OG001"],"nonInferiorityType":"SUPERIORITY_OR_OTHER","pValue":"0.9608","paramType":"Odds Ratio (OR)","paramValue":"0.93","statisticalMethod":"Conditional Logistic Regression"},{"ciLowerLimit":"0.78","ciNumSides":"TWO_SIDED","ciPctValue":"95","ciUpperLimit":"24.07","estimateComment":"Comparison: \"Tertile 3 (without 2 year lag)\" and \"Never (without 2 year lag)\".","groupIds":["OG000","OG001"],"nonInferiorityType":"SUPERIORITY_OR_OTHER","pValue":"0.0944","paramType":"Odds Ratio (OR)","paramValue":"4.33","statisticalMethod":"Conditional Logistic Regression"},{"ciLowerLimit":"0.10","ciNumSides":"TWO_SIDED","ciPctValue":"95","ciUpperLimit":"7.82","estimateComment":"Comparison: \"Tertile 3 (without 2 year lag)\" and \"Never (without 2 year lag)\". Adjusted for smoking, BMI, diabetes, neuropathic pain, back pain, epilepsy, HIV, HPV (genital).","groupIds":["OG000","OG001"],"nonInferiorityType":"SUPERIORITY_OR_OTHER","pValue":"0.9253","paramType":"Odds Ratio (OR)","paramValue":"0.90","statisticalMethod":"Conditional Logistic Regression"}],"classes":[{"categories":[{"measurements":[{"groupId":"OG000","value":"208"},{"groupId":"OG001","value":"2061"}]}],"title":"Never (with 2 year lag)"},{"categories":[{"measurements":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"1"}]}],"title":"Tertile 1 (with 2 year lag)"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"2"}]}],"title":"Tertile 2 (with 2 year lag)"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"3"}]}],"title":"Tertile 3 (with 2 year lag)"},{"categories":[{"measurements":[{"groupId":"OG000","value":"207"},{"groupId":"OG001","value":"2052"}]}],"title":"Never (without 2 year lag)"},{"categories":[{"measurements":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"7"}]}],"title":"Tertile 1 (without 2 year lag)"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"3"}]}],"title":"Tertile 2 (without 2 year lag)"},{"categories":[{"measurements":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"5"}]}],"title":"Tertile 3 (without 2 year lag)"}],"denoms":[{"counts":[{"groupId":"OG000","value":"212"},{"groupId":"OG001","value":"2067"}],"units":"Participants"}],"description":"Incident anal cancer. Gabapentin (Gaba.) Exposure Description: With 2 year (yr) lag=Gaba. exposure from cohort entry to 2 yr prior to index date (to control for prediagnostic prescribing for pain symptoms possibly related to cancer). Without 2 yr lag=Gaba. exposure from cohort entry to index date. Tertiles (T) with 2 yr lag: T 1 (1-2 prescriptions \\[prescrip.\\]), T 2 (3-7 prescrip.), T 3 (8-298 prescrip.). Tertiles without 2 yr lag: T 1 (1-2 prescrip.), T 2 (3-7 prescrip.), and T 3 (8-388 prescrip.). Inestimable OR and 95% CI when no gaba.-exposed cancer cases or controls at the exposure level.","groups":[{"description":"Patients with incident anal cancer defined from READ/OXMIS codes in the years 1995-2008","id":"OG000","title":"Incident Anal Cancer Patients"},{"description":"Cancer-free control patients risk set matched with incident anal cancer patients for sex, age at cohort entry (within two years), calendar year of cohort entry (within one year), and General Practice site","id":"OG001","title":"Matched Controls for Incident Anal Cancer Patients"}],"paramType":"NUMBER","populationDescription":"Cases \\& controls drawn from the GPRD study cohort. Entry into study cohort began January 1, 1993, or at time of GPRD registration if after Jan. 1, 1993. Follow-up ended December 31, 2008, or earlier if respective cancer was diagnosed or if participant left the GPRD for any reason including death. Participants with prior history of cancer excluded.","reportingStatus":"POSTED","timeFrame":"The case index date was the date of incident anal cancer diagnosis ascertained in the GPRD study cohort 1995-2008. The matched control index date was the date at which the follow-up time from his/her cohort entry was the same as that for the case.","title":"Number of Anal Cancer Cases and Matched Controls With the Indicated Number of Gabapentin Prescriptions","type":"PRIMARY","unitOfMeasure":"participants"}