{"analyses":[{"ciLowerLimit":"1.01","ciNumSides":"TWO_SIDED","ciPctValue":"95","ciUpperLimit":"1.41","estimateComment":"Comparison: \"\\> 1 year (with 2 year lag)\" and \"Never (with 2 year lag)\".","groupIds":["OG000","OG001"],"nonInferiorityType":"SUPERIORITY_OR_OTHER","pValue":"0.0369","paramType":"Odds Ratio (OR)","paramValue":"1.20","statisticalMethod":"Conditional Logistic Regression"},{"ciLowerLimit":"0.92","ciNumSides":"TWO_SIDED","ciPctValue":"95","ciUpperLimit":"1.29","estimateComment":"Comparison: \"\\> 1 year (with 2 year lag)\" and \"Never (with 2 year lag)\". Adjusted for smoking, BMI, alcohol consumption, diabetes, neuropathic pain, back pain, epilepsy.","groupIds":["OG000","OG001"],"nonInferiorityType":"SUPERIORITY_OR_OTHER","pValue":"0.3132","paramType":"Odds Ratio (OR)","paramValue":"1.09","statisticalMethod":"Conditional Logistic Regression"},{"ciLowerLimit":"0.99","ciNumSides":"TWO_SIDED","ciPctValue":"95","ciUpperLimit":"1.26","estimateComment":"Comparison: \"\\> 1 year (without 2 year lag)\" and \"Never (without 2 year lag)\".","groupIds":["OG000","OG001"],"nonInferiorityType":"SUPERIORITY_OR_OTHER","pValue":"0.0762","paramType":"Odds Ratio (OR)","paramValue":"1.12","statisticalMethod":"Conditional Logistic Regression"},{"ciLowerLimit":"0.91","ciNumSides":"TWO_SIDED","ciPctValue":"95","ciUpperLimit":"1.15","estimateComment":"Comparison: \"\\> 1 year (without 2 year lag)\" and \"Never (without 2 year lag)\". Adjusted for smoking, BMI, alcohol consumption, diabetes, neuropathic pain, back pain, epilepsy.","groupIds":["OG000","OG001"],"nonInferiorityType":"SUPERIORITY_OR_OTHER","pValue":"0.7243","paramType":"Odds Ratio (OR)","paramValue":"1.02","statisticalMethod":"Conditional Logistic Regression"},{"ciLowerLimit":"0.97","ciNumSides":"TWO_SIDED","ciPctValue":"95","ciUpperLimit":"1.65","estimateComment":"Comparison: \"\\> 2 years (with 2 year lag)\" and \"Never (with 2 year lag)\".","groupIds":["OG000","OG001"],"nonInferiorityType":"SUPERIORITY_OR_OTHER","pValue":"0.0775","paramType":"Odds Ratio (OR)","paramValue":"1.27","statisticalMethod":"Conditional Logistic Regression"},{"ciLowerLimit":"0.89","ciNumSides":"TWO_SIDED","ciPctValue":"95","ciUpperLimit":"1.52","estimateComment":"Comparison: \"\\> 2 years (with 2 year lag)\" and \"Never (with 2 year lag)\". Adjusted for smoking, BMI, alcohol consumption, diabetes, neuropathic pain, back pain, epilepsy.","groupIds":["OG000","OG001"],"nonInferiorityType":"SUPERIORITY_OR_OTHER","pValue":"0.2649","paramType":"Odds Ratio (OR)","paramValue":"1.16","statisticalMethod":"Conditional Logistic Regression"},{"ciLowerLimit":"1.02","ciNumSides":"TWO_SIDED","ciPctValue":"95","ciUpperLimit":"1.43","estimateComment":"Comparison: \"\\> 2 years (without 2 year lag)\" and \"Never (without 2 year lag)\".","groupIds":["OG000","OG001"],"nonInferiorityType":"SUPERIORITY_OR_OTHER","pValue":"0.0257","paramType":"Odds Ratio (OR)","paramValue":"1.21","statisticalMethod":"Conditional Logistic Regression"},{"ciLowerLimit":"0.93","ciNumSides":"TWO_SIDED","ciPctValue":"95","ciUpperLimit":"1.30","estimateComment":"Comparison: \"\\> 2 years (without 2 year lag)\" and \"Never (without 2 year lag)\". Adjusted for smoking, BMI, alcohol consumption, diabetes, neuropathic pain, back pain, epilepsy.","groupIds":["OG000","OG001"],"nonInferiorityType":"SUPERIORITY_OR_OTHER","pValue":"0.2540","paramType":"Odds Ratio (OR)","paramValue":"1.10","statisticalMethod":"Conditional Logistic Regression"},{"ciLowerLimit":"0.76","ciNumSides":"TWO_SIDED","ciPctValue":"95","ciUpperLimit":"1.75","estimateComment":"Comparison: \"\\> 3 years (with 2 year lag)\" and \"Never (with 2 year lag)\".","groupIds":["OG000","OG001"],"nonInferiorityType":"SUPERIORITY_OR_OTHER","pValue":"0.5141","paramType":"Odds Ratio (OR)","paramValue":"1.15","statisticalMethod":"Conditional Logistic Regression"},{"ciLowerLimit":"0.69","ciNumSides":"TWO_SIDED","ciPctValue":"95","ciUpperLimit":"1.60","estimateComment":"Comparison: \"\\> 3 years (with 2 year lag)\" and \"Never (with 2 year lag)\". Adjusted for smoking, BMI, alcohol consumption, diabetes, neuropathic pain, back pain, epilepsy.","groupIds":["OG000","OG001"],"nonInferiorityType":"SUPERIORITY_OR_OTHER","pValue":"0.8208","paramType":"Odds Ratio (OR)","paramValue":"1.05","statisticalMethod":"Conditional Logistic Regression"},{"ciLowerLimit":"0.99","ciNumSides":"TWO_SIDED","ciPctValue":"95","ciUpperLimit":"1.62","estimateComment":"Comparison: \"\\> 3 years (without 2 year lag)\" and \"Never (without 2 year lag)\".","groupIds":["OG000","OG001"],"nonInferiorityType":"SUPERIORITY_OR_OTHER","pValue":"0.0562","paramType":"Odds Ratio (OR)","paramValue":"1.27","statisticalMethod":"Conditional Logistic Regression"},{"ciLowerLimit":"0.90","ciNumSides":"TWO_SIDED","ciPctValue":"95","ciUpperLimit":"1.47","estimateComment":"Comparison: \"\\> 3 years (without 2 year lag)\" and \"Never (without 2 year lag)\". Adjusted for smoking, BMI, alcohol consumption, diabetes, neuropathic pain, back pain, epilepsy.","groupIds":["OG000","OG001"],"nonInferiorityType":"SUPERIORITY_OR_OTHER","pValue":"0.2596","paramType":"Odds Ratio (OR)","paramValue":"1.15","statisticalMethod":"Conditional Logistic Regression"}],"classes":[{"categories":[{"measurements":[{"groupId":"OG000","value":"178334"},{"groupId":"OG001","value":"1704443"}]}],"title":"Never (with 2 year lag)"},{"categories":[{"measurements":[{"groupId":"OG000","value":"157"},{"groupId":"OG001","value":"1217"}]}],"title":"> 1 year (with 2 year lag)"},{"categories":[{"measurements":[{"groupId":"OG000","value":"64"},{"groupId":"OG001","value":"463"}]}],"title":"> 2 year (with 2 year lag)"},{"categories":[{"measurements":[{"groupId":"OG000","value":"25"},{"groupId":"OG001","value":"197"}]}],"title":"> 3 year (with 2 year lag)"},{"categories":[{"measurements":[{"groupId":"OG000","value":"177409"},{"groupId":"OG001","value":"1698480"}]}],"title":"Never (without 2 year lag)"},{"categories":[{"measurements":[{"groupId":"OG000","value":"301"},{"groupId":"OG001","value":"2499"}]}],"title":"> 1 year (without 2 year lag)"},{"categories":[{"measurements":[{"groupId":"OG000","value":"159"},{"groupId":"OG001","value":"1207"}]}],"title":"> 2 year (without 2 year lag)"},{"categories":[{"measurements":[{"groupId":"OG000","value":"76"},{"groupId":"OG001","value":"549"}]}],"title":"> 3 year (without 2 year lag)"}],"denoms":[{"counts":[{"groupId":"OG000","value":"179138"},{"groupId":"OG001","value":"1710950"}],"units":"Participants"}],"description":"Incidence of all cancers. Gabapentin Exposure Description: With 2 year lag = Gabapentin exposure from cohort entry to 2 years prior to index date (to control for prediagnostic prescribing for pain symptoms possibly related to cancer). Without 2 year lag = Gabapentin exposure from cohort entry to index date.","groups":[{"description":"Patients with any type of incident cancer defined from READ/OXMIS codes in the years 1995-2008","id":"OG000","title":"Incident All-cancer Patients"},{"description":"Cancer-free control patients risk set matched with incident all-cancer patients for sex, age at cohort entry (within two years), calendar year of cohort entry (within one year), and General Practice site","id":"OG001","title":"Matched Controls for Incident All-cancer Patients"}],"paramType":"NUMBER","populationDescription":"Cases \\& controls drawn from the GPRD study cohort. Entry into study cohort began January 1, 1993, or at time of GPRD registration if after Jan. 1, 1993. Follow-up ended December 31, 2008, or earlier if respective cancer was diagnosed or if participant left the GPRD for any reason including death. Participants with prior history of cancer excluded.","reportingStatus":"POSTED","timeFrame":"The case index date was the date of incident cancer diagnosis ascertained in the GPRD study cohort 1995-2008. The matched control index date was the date at which the follow-up time from his/her cohort entry was the same as that for the case.","title":"Number of All-Cancer Cases and Matched Controls With the Indicated Long Duration of Exposure to Gabapentin","type":"PRIMARY","unitOfMeasure":"participants"}