{"denoms":[{"counts":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"},{"groupId":"OG004","value":"0"},{"groupId":"OG005","value":"0"},{"groupId":"OG006","value":"0"},{"groupId":"OG007","value":"0"}],"units":"Participants"}],"description":"Treatments ability to reduce values of 5 symptoms comprised of MD Anderson Symptom Inventory (MDASI)-Head and Neck Cancer (HNC) scores for fatigue, difficulty swallowing, sleep disturbance, pain, and lack of appetite collected during the 10 weeks of chemoradiation treatment. symptoms that are caused by their disease or by their treatment. Symptom severity score is comprised of average of the five above MDASI core items (fatigue, difficulty swallowing, sleep disturbance, pain, and lack of appetite). Participants were asked to rate severity of each symptom at their worst in last 24 hours; each item rated from 0 to 10, with 0 = symptom not present and 10 = as bad as you can imagine. Total average score range: 0 to 10. Lower scores indicated better outcome.","groups":[{"description":"Placebo by mouth 2 times every day.\n\nPlacebo: 1 by mouth twice a day.","id":"OG000","title":"Placebo"},{"description":"Armodafinil 150 mg by mouth once a day.\n\nArmodafinil: 150 mg by mouth once a day.","id":"OG001","title":"Armodafinil"},{"description":"Minocycline 100 mg by muth two times a day.\n\nMinocycline: 100 mg by mouth twice a day.","id":"OG002","title":"Minocycline"},{"description":"Bupropion 100 mg by mouth two times a day.\n\nBupropion: 100 mg by mouth twice a day.","id":"OG003","title":"Bupropion"},{"description":"Armodafinil 150 mg by mouth once a day.\n\nMinocycline 100 mg by mouth two times a day.\n\nArmodafinil: 150 mg by mouth once a day.\n\nMinocycline: 100 mg by mouth twice a day.","id":"OG004","title":"Armodafinil + Minocycline"},{"description":"Armodafinil 150 mg by mouth once a day.\n\nBupropion 100 mg by mouth two times a day.\n\nArmodafinil: 150 mg by mouth once a day.\n\nBupropion: 100 mg by mouth twice a day.","id":"OG005","title":"Armodafinil + Bupropion"},{"description":"Minocycline 100 mg by muth two times a day.\n\nBupropion 100 mg by mouth two times a day.\n\nMinocycline: 100 mg by mouth twice a day.\n\nBupropion: 100 mg by mouth twice a day.","id":"OG006","title":"Minocycline + Bupropion"},{"description":"Armodafinil 150 mg by mouth once a day.\n\nMinocycline 100 mg by muth two times a day.\n\nBupropion 100 mg by mouth two times a day.\n\nArmodafinil: 150 mg by mouth once a day.\n\nMinocycline: 100 mg by mouth twice a day.\n\nBupropion: 100 mg by mouth twice a day.","id":"OG007","title":"Armodafinil + Minocycline + Bupropion"}],"populationDescription":"No analysis was completed. Study terminated with low enrollment.","reportingStatus":"POSTED","timeFrame":"10 weeks","title":"Treatment Effects on 5 Selected Symptoms (Average MDASI-HNC Scores)","type":"PRIMARY"}