{"analyses":[{"ciNumSides":"TWO_SIDED","estimateComment":"Maximum Tolerated Dose Level is Dose Level 2 (1.3 mg/m\\^2 Bortezomib).","groupIds":["OG000","OG001"],"nonInferiorityType":"OTHER","paramType":"Maximum Tolerated Dose (MTD) (mg/m^2)","paramValue":"1.3"}],"classes":[{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"1"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"6"}],"units":"Participants"}],"description":"MTD is defined as the dose level below the lowest dose that induces dose-limiting toxicity in at least one-third of patients (at least 2 of a maximum of 6 new patients).","groups":[{"description":"Patients receive oral pomalidomide on days 1-21; bortezomib IV on days 1, 8, 15, 22; and oral dexamethasone on days 1, 8, 15, 22. Treatment repeats every 28 days for 8 courses. Patients then receive maintenance therapy comprising oral pomalidomide on days 1-21. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity. 1.0 mg/m2 Bortezomib, 4 mg Pomalidomide, 40 mg Dexamethasone","id":"OG000","title":"Phase 1 Dose Level 1"},{"description":"Patients receive oral pomalidomide on days 1-21; bortezomib IV on days 1, 8, 15, 22; and oral dexamethasone on days 1, 8, 15, 22. Treatment repeats every 28 days for 8 courses. Patients then receive maintenance therapy comprising oral pomalidomide on days 1-21. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity. 1.3 mg/m2 Bortezomib, 4 mg Pomalidomide, 40 mg Dexamethasone","id":"OG001","title":"Phase 1 Dose Level 2"}],"paramType":"COUNT_OF_PARTICIPANTS","populationDescription":"The first 9 patients accrued(All Phase 1 patients) were evaluated for the MTD.","reportingStatus":"POSTED","timeFrame":"2.5 years","title":"Find Maximum Tolerated Dose (MTD) of Bortezomib in Combination With Pomalidomide and Dexamethasone Out to 2.5 Years, by Count of Patients With Dose Limiting Toxicities.","type":"PRIMARY","unitOfMeasure":"Participants"}