{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"4.2","value":"9.0"},{"groupId":"OG001","spread":"2.4","value":"3.9"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"26"},{"groupId":"OG001","value":"74"}],"units":"Participants"}],"title":"Global Health Status"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"2.3","value":"2.6"},{"groupId":"OG001","spread":"1.9","value":"2.2"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"26"},{"groupId":"OG001","value":"74"}],"units":"Participants"}],"title":"Physical Functioning"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"8.5","value":"12.2"},{"groupId":"OG001","spread":"3.5","value":"1.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"15"},{"groupId":"OG001","value":"72"}],"units":"Participants"}],"title":"Role Functioning"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"4.9","value":"6.5"},{"groupId":"OG001","spread":"2.7","value":"5.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"26"},{"groupId":"OG001","value":"74"}],"units":"Participants"}],"title":"Emotional Functioning"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"5.2","value":"-3.3"},{"groupId":"OG001","spread":"2.5","value":"-2.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"15"},{"groupId":"OG001","value":"74"}],"units":"Participants"}],"title":"Cognitive Functioning"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"8.5","value":"12.2"},{"groupId":"OG001","spread":"3.8","value":"14.9"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"15"},{"groupId":"OG001","value":"74"}],"units":"Participants"}],"title":"Social Functioning"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"5.5","value":"-5.9"},{"groupId":"OG001","spread":"2.4","value":"-5.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"15"},{"groupId":"OG001","value":"74"}],"units":"Participants"}],"title":"Fatigue Symptom"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"4.7","value":"-4.5"},{"groupId":"OG001","spread":"2.0","value":"-2.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"26"},{"groupId":"OG001","value":"73"}],"units":"Participants"}],"title":"Nausea and Vomiting Symptom"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"3.6","value":"3.8"},{"groupId":"OG001","spread":"2.7","value":"-1.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"26"},{"groupId":"OG001","value":"74"}],"units":"Participants"}],"title":"Pain Symptom"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"4.7","value":"-9.0"},{"groupId":"OG001","spread":"2.9","value":"-0.9"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"26"},{"groupId":"OG001","value":"74"}],"units":"Participants"}],"title":"Dyspnea Symptom"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"3.2","value":"-2.6"},{"groupId":"OG001","spread":"3.5","value":"3.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"26"},{"groupId":"OG001","value":"73"}],"units":"Participants"}],"title":"Insomnia Symptom"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"6.4","value":"-17.8"},{"groupId":"OG001","spread":"3.4","value":"-9.1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"15"},{"groupId":"OG001","value":"73"}],"units":"Participants"}],"title":"Appetite Loss Symptom"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"3.6","value":"-5.1"},{"groupId":"OG001","spread":"2.2","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"26"},{"groupId":"OG001","value":"74"}],"units":"Participants"}],"title":"Constipation Symptom"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"5.5","value":"5.1"},{"groupId":"OG001","spread":"2.3","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"26"},{"groupId":"OG001","value":"74"}],"units":"Participants"}],"title":"Diarrhea Symptom"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"4.8","value":"-5.1"},{"groupId":"OG001","spread":"2.9","value":"-0.9"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"26"},{"groupId":"OG001","value":"72"}],"units":"Participants"}],"title":"Financial Difficulties Symptom"}],"denoms":[{"counts":[{"groupId":"OG000","value":"111"},{"groupId":"OG001","value":"74"}],"units":"Participants"}],"description":"The European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-C30 (EORTC QLQ-C30) is a 30-question tool used to assess the overall quality of life in cancer patients. It consists of 15 domains: 1 global health status (GHS) scale, 5 functional scales (Physical, Role, Cognitive, Emotional, Social), and 9 symptom scales/items (Fatigue, Nausea and Vomiting, Pain, Dyspnea, Insomnia, Appetite Loss, Constipation, Diarrhea, Financial Impact).\n\nFor each of these scales, scores range from 0 to 100. For the GHS and 5 functional scales a high score indicates better global health status/functioning and a positive change from baseline indicates improvement. For the 9 symptom scales, a high score indicates a higher level of symptoms, and a negative change from Baseline indicates an improvement in symptoms.\n\nThe maximum changes from baseline to cycles 1 through 4 and the change from baseline to the end of the core study are reported.","dispersionType":"Standard Error","groups":[{"id":"OG000","title":"Maximum Change From Baseline in Cycles 1 - 4"},{"id":"OG001","title":"Change From Baseline at End of Core Study"}],"paramType":"MEAN","populationDescription":"FAS with available data at relevant time points. For maximum change, the change from baseline was calculated using subset of FAS with available data (baseline and post-baseline) at the end of each cycle. The number analyzed are the number of subjects with available data at the time point at which maximum change from baseline was observed.","reportingStatus":"POSTED","timeFrame":"Baseline and the end of each treatment cycle (day 29 of each cycle) and 30 days after end of the last infusion (end of the core study, a maximum of 26 weeks).","title":"Change From Baseline in EORTC-QLQ-C30 Scales","type":"SECONDARY","unitOfMeasure":"units on a scale"}