{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"48.0","value":"78.6"},{"groupId":"OG001","spread":"47.9","value":"76.0"}]}],"title":"Doxorubicin"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"1.6","value":"3.0"},{"groupId":"OG001","spread":"0.7","value":"2.4"}]}],"title":"Etoposide"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"10.2","value":"22.4"},{"groupId":"OG001","spread":"8.9","value":"16.8"}]}],"title":"Vincristine"}],"denoms":[{"counts":[{"groupId":"OG000","value":"6"},{"groupId":"OG001","value":"5"},{"groupId":"OG002","value":"0"}],"units":"Participants"}],"description":"Serial plasma samples for pharmacokinetic analysis were collected at 24-48, 48-72, and 72-96 hours after the start of the first chemotherapy infusion. Doxorubicin, etoposide, and vincristine concentrations were determined using a validated liquid chromatography-tandem mass spectrometry method. The clearance was determined by dividing the drug-infusion rate by the steady-state concentrations, which was the average of the three time points.","dispersionType":"Standard Deviation","groups":[{"description":"Arm A (VR-DA-EPOCH) with Vorinostat at 300 mg once a day on days 1-5 of a cycle (Phase I Dose Level 1)","id":"OG000","title":"Phase I: VR-DA-EPOCH, Dose Level 1"},{"description":"Arm A (VR-DA-EPOCH) with Vorinostat at 400 mg once a day on days 1-5 of a cycle (Phase I Dose Level 2)","id":"OG001","title":"Phase I: VR-DA-EPOCH, Dose Level 2"},{"description":"Arm C (VR-CHOP) with Vorinostat at 300 mg once a day on days 1-5 of a cycle (Phase I Dose Level 1 for low risk participants). This arm was discontinued due to low accrual.","id":"OG002","title":"Phase I: VR-CHOP, Dose Level 1"}],"paramType":"MEAN","populationDescription":"Phase I participants with evaluable pharmacokinetic data","reportingStatus":"POSTED","timeFrame":"24-48, 48-72, and 72-96 hours after the start of the first chemotherapy infusion","title":"Pharmacokinetic Clearance (Phase I)","type":"SECONDARY","unitOfMeasure":"Liter/hour"}