{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"97.14","upperLimit":"100.00","value":"98.75"},{"groupId":"OG001","lowerLimit":"96.75","upperLimit":"100.00","value":"98.50"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"301"},{"groupId":"OG001","value":"302"}],"units":"Participants"}],"description":"DFS is calculated as the time from randomization at the end of Induction to first event (relapse, second malignancy, remission death) or date of last contact. Five year DFS estimates will be calculated from the point of randomization for both groups. Two-sided 95% confidence intervals will be calculated.","dispersionType":"95% Confidence Interval","groups":[{"description":"Consolidation (19 w): vincristine (VIN) day(d) 15/22/78/85; IV/IT methotrexate (MTX) d8/29/50/71/92/113; leucovorin (LV) d9-10/30-31/51-52/72-73/93-94/114-115; dexamethasone (DEX) d15-21/78-84; mercaptopurine (MP) d 1-133. Maint.: VIN d1/8; DEX d1-7; MTX\\* PO wkly d1-106; MP d 1-112. Repeat every 16 w until 2.5 yrs from dx. IT MTX d1/85 (course 1\\&4), d 57 (course 2\\&5), d29 (course 3\\&6). Course 7: VIN d1/8; DEX d 1-7; MTX PO wkly d8-64; and MP d1-70. \\*Patients do not receive MTX PO on d w/ IT MTX.","id":"OG000","title":"B-ALL Low Risk Arm I (LR-M)"},{"description":"Consolidation (4 w): VIN d1; MP d1-28; IT MTX d1/8/15 Interim Maint. I (8 w): VIN \\& IV MTX d1/11/21/31/41; IT MTX d31 Delayed-intensification (8 w): DEX d1-7/15-21; VIN \\& doxorubicin d1/8/15; pegaspargase d4; cyclophosphamide d29; thioguanine d 29-42; cytarabine d29-32/36-39; IT MTX d1/29 Interim Maint. II (8 w): VIN \\& IV MTX d1/11/21/31/41; IT MTX d1/31 Maint.: VIN d1; DEX d1-5; MTX PO wkly d22-78; MP d 1-84; IT MTX d1. Rpt every 12 w for 2 yrs:girls, 3 yrs:boys from start IM1","id":"OG001","title":"B-ALL Low Risk Arm II (LR-C)"}],"paramType":"NUMBER","reportingStatus":"POSTED","timeFrame":"5.1 years","title":"DFS in Low Risk (LR) Patients Based on Randomization to 1 of 2 Low-intensity Regimens","type":"PRIMARY","unitOfMeasure":"percent probability"}