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CD19+"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-69.2","upperLimit":"20.1","value":"-39.4"},{"groupId":"OG001","lowerLimit":"-58.1","upperLimit":"8.3","value":"-20.0"},{"groupId":"OG002","lowerLimit":"-63.7","upperLimit":"-13.2","value":"-49.4"},{"groupId":"OG003","lowerLimit":"-32.4","upperLimit":"-16.6","value":"-24.5"},{"groupId":"OG004","lowerLimit":"-43.0","upperLimit":"-43.0","value":"-43.0"},{"groupId":"OG005","lowerLimit":"-57.6","upperLimit":"28.1","value":"-24.9"},{"groupId":"OG006","lowerLimit":"-64.2","upperLimit":"-25.1","value":"-51.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"10"},{"groupId":"OG001","value":"16"},{"groupId":"OG002","value":"6"},{"groupId":"OG003","value":"2"},{"groupId":"OG004","value":"1"},{"groupId":"OG005","value":"18"},{"groupId":"OG006","value":"3"}],"units":"Participants"}],"title":"Day 1,1.5 hours post-dose - CD91+"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-53.7","upperLimit":"151.3","value":"-22.4"},{"groupId":"OG001","lowerLimit":"-39.7","upperLimit":"16.8","value":"-24.7"},{"groupId":"OG003","lowerLimit":"-6.9","upperLimit":"-6.9","value":"-6.9"},{"groupId":"OG005","lowerLimit":"-38.4","upperLimit":"77.5","value":"-24.8"},{"groupId":"OG006","lowerLimit":"-7.9","upperLimit":"47.2","value":"19.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"9"},{"groupId":"OG001","value":"44"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"1"},{"groupId":"OG004","value":"0"},{"groupId":"OG005","value":"9"},{"groupId":"OG006","value":"2"}],"units":"Participants"}],"title":"Day 15, 1.5 hours post-dose - 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Data is reported by T-cell subsets known as clusters of differentiation (CD).","dispersionType":"Full Range","groups":[{"description":"Participants with GBM received CC-223 at a starting dose of 45 mg/day (reduced to 30 mg/day after protocol Amendment 9) orally once a day in 28-day cycles for as long as they derived benefit from treatment as judged by the investigator.","id":"OG000","title":"Part B: Glioblastoma Multiforme (GBM)"},{"description":"Participants with HCC received CC-223 at a starting dose of 45 mg/day (reduced to 30 mg/day after protocol Amendment 9) orally once a day in 28-day cycles for as long as they derived benefit from treatment as judged by the investigator.","id":"OG001","title":"Part B: Hepatocellular Carcinoma (HCC)"},{"description":"Participants with NET received CC-223 at a starting dose of 45 mg/day (reduced to 30 mg/day after protocol Amendment 9) orally once a day in 28-day cycles for as long as they derived benefit from treatment as judged by the investigator.","id":"OG002","title":"Part B: Neuroendocrine Tumor (NET)"},{"description":"Participants with DLBCL received CC-223 at a starting dose of 45 mg/day (reduced to 30 mg/day after protocol Amendment 9) orally once a day in 28-day cycles for as long as they derived benefit from treatment as judged by the investigator.","id":"OG003","title":"Part B: Diffuse Large B-cell Lymphoma (DLBCL)"},{"description":"Participants with HRPBC received CC-223 at a starting dose of 45 mg/day (reduced to 30 mg/day after protocol Amendment 9) orally once a day in 28-day cycles for as long as they derived benefit from treatment as judged by the investigator.","id":"OG004","title":"Part B: Hormone Receptor Positive Breast Cancer (HRPBC)"},{"description":"Participants with NSCLC received CC-223 at a starting dose of 45 mg/day (reduced to 30 mg/day after protocol Amendment 9) orally once a day in 28-day cycles for as long as they derived benefit from treatment as judged by the investigator.","id":"OG005","title":"Part B: Non-small Cell Lung Cancer (NSCLC)"},{"description":"Participants with MM received CC-223 at a starting dose of 45 mg/day (reduced to 30 mg/day after protocol Amendment 9) orally once a day in 28-day cycles for as long as they derived benefit from treatment as judged by the investigator.","id":"OG006","title":"Part B: Multiple Myeloma (MM)"}],"paramType":"MEDIAN","populationDescription":"All biomarker evaluable participants who received treatment in Part B.","reportingStatus":"POSTED","timeFrame":"Cycle 1 Day 1: 1.5 hours post-dose and Day 15: 1.5 hours post-dose","title":"Part B: Percent Change From Baseline in p4E-BP1 in Monocytes by Tumor Cohort","type":"SECONDARY","unitOfMeasure":"Percent change in p4E-BP1"}