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extension"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"17.51","value":"2.1"},{"groupId":"OG001","spread":"16.73","value":"-0.2"},{"groupId":"OG002","spread":"15.15","value":"7.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"19"},{"groupId":"OG001","value":"12"},{"groupId":"OG002","value":"16"}],"units":"Participants"}],"title":"Week 232 extension"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"20.06","value":"4.5"},{"groupId":"OG001","spread":"11.05","value":"6.3"},{"groupId":"OG002","spread":"18.65","value":"3.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"13"},{"groupId":"OG001","value":"7"},{"groupId":"OG002","value":"10"}],"units":"Participants"}],"title":"Week 244 extension"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"25.91","value":"6.1"},{"groupId":"OG001","spread":"7.07","value":"-3.0"},{"groupId":"OG002","spread":"14.08","value":"0.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"10"},{"groupId":"OG001","value":"6"},{"groupId":"OG002","value":"7"}],"units":"Participants"}],"title":"Week 256 extension"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"16.74","value":"0.6"},{"groupId":"OG001","spread":"4.30","value":"-4.9"},{"groupId":"OG002","spread":"7.57","value":"-10.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"4"},{"groupId":"OG001","value":"3"},{"groupId":"OG002","value":"3"}],"units":"Participants"}],"title":"Week 268 extension"}],"denoms":[{"counts":[{"groupId":"OG000","value":"57"},{"groupId":"OG001","value":"54"},{"groupId":"OG002","value":"62"}],"units":"Participants"}],"description":"Acromegaly Quality of Life questionnaire (AcroQoL) is a validated disease specific questionnaire. It contains 22 items divided into two scales: physical aspects (8 items) and psychological aspects (14 items) which is divided in two sub-scales: physical appearance and personal relationships of the patient (seven items each). The total score and sub-scores were calculated using the following formula: ((X -Y) / 4Y) x 100, X=sum of the scores for individual items (between 1 and 5 for each item), Y=number of individual items included in above sum (i.e. 22 for the total score, 8 for the physical sub-score, 14 for the psychological sub-score, 7 for the sub-score 'appearance' and 'personal relations'). The scoring of the questionnaire was performed as specified by the instrument developers. Total scores range from 0 to 100. Higher scores represent better quality of life. If more than 25% of items are not completed, results were considered invalid.","dispersionType":"Standard Deviation","groups":[{"description":"If controlled on 40 mg in CORE, remain on blinded 40 mg in extension. If patient became uncontrolled, switch to open label 60 mg","id":"OG000","title":"Pasireotide LAR 40 mg Extension"},{"description":"If controlled on 60 mg in CORE, remain on blinded 60 mg in extension. If patient became uncontrolled, switch to open label 60 mg","id":"OG001","title":"Pasireotide LAR 60 mg Extension"},{"description":"Open - label 60 mg pasireotide. Control group from CORE discontinued study if controlled in CORE. If uncontrolled in CORE, switched to open label 60 mg pasireotide. Extension blinded 40 and 60 mg switched to open label if became uncontrolled.","id":"OG002","title":"Cross Over to Pasireotide Extension"}],"paramType":"MEAN","populationDescription":"completed and valid questionnaires at visits","reportingStatus":"POSTED","timeFrame":"CORE Baseline and extension baseline up to approximately 268 weeks","title":"Change From Baseline in AcroQoL Total Scores for Patients Treated With Pasireotide LAR Alone or With Concomitant Medications Used to Treat Acromegaly for Extension Visits (Extension Full Analysis Set)","type":"SECONDARY","unitOfMeasure":"scores on a scale"}