{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.99","value":"-0.8"},{"groupId":"OG001","spread":"0.97","value":"-1.4"},{"groupId":"OG002","spread":"0.81","value":"-0.9"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"49"},{"groupId":"OG001","value":"47"},{"groupId":"OG002","value":"61"}],"units":"Participants"}],"title":"Week 16 extension"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"1.00","value":"-0.9"},{"groupId":"OG001","spread":"1.13","value":"-1.3"},{"groupId":"OG002","spread":"0.88","value":"-0.9"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"45"},{"groupId":"OG001","value":"39"},{"groupId":"OG002","value":"58"}],"units":"Participants"}],"title":"Week 28 extension"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.95","value":"-1.1"},{"groupId":"OG001","spread":"0.94","value":"-1.4"},{"groupId":"OG002","spread":"0.91","value":"-1.1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"42"},{"groupId":"OG001","value":"37"},{"groupId":"OG002","value":"51"}],"units":"Participants"}],"title":"Week 40 extension"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.90","value":"-1.1"},{"groupId":"OG001","spread":"0.95","value":"-1.3"},{"groupId":"OG002","spread":"0.95","value":"-1.1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"39"},{"groupId":"OG001","value":"37"},{"groupId":"OG002","value":"46"}],"units":"Participants"}],"title":"Week 52 extension"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.99","value":"-1.3"},{"groupId":"OG001","spread":"0.98","value":"-1.4"},{"groupId":"OG002","spread":"0.81","value":"-1.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"37"},{"groupId":"OG001","value":"35"},{"groupId":"OG002","value":"42"}],"units":"Participants"}],"title":"Week 64 extension"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.87","value":"-1.3"},{"groupId":"OG001","spread":"0.94","value":"-1.5"},{"groupId":"OG002","spread":"0.84","value":"-1.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"33"},{"groupId":"OG001","value":"36"},{"groupId":"OG002","value":"43"}],"units":"Participants"}],"title":"Week 76 extension"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.80","value":"-1.3"},{"groupId":"OG001","spread":"1.01","value":"-1.6"},{"groupId":"OG002","spread":"0.90","value":"-1.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"33"},{"groupId":"OG001","value":"32"},{"groupId":"OG002","value":"41"}],"units":"Participants"}],"title":"Week 88 extension"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.93","value":"-1.4"},{"groupId":"OG001","spread":"0.95","value":"-1.5"},{"groupId":"OG002","spread":"0.92","value":"-1.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"32"},{"groupId":"OG001","value":"32"},{"groupId":"OG002","value":"40"}],"units":"Participants"}],"title":"Week 100 extension"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.87","value":"-1.5"},{"groupId":"OG001","spread":"1.00","value":"-1.5"},{"groupId":"OG002","spread":"0.89","value":"-1.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"31"},{"groupId":"OG001","value":"32"},{"groupId":"OG002","value":"38"}],"units":"Participants"}],"title":"Week 112 extension"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.86","value":"-1.4"},{"groupId":"OG001","spread":"0.95","value":"-1.5"},{"groupId":"OG002","spread":"0.97","value":"-1.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"31"},{"groupId":"OG001","value":"28"},{"groupId":"OG002","value":"38"}],"units":"Participants"}],"title":"Week 124 extension"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.91","value":"-1.4"},{"groupId":"OG001","spread":"0.92","value":"-1.7"},{"groupId":"OG002","spread":"0.86","value":"-1.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"29"},{"groupId":"OG001","value":"27"},{"groupId":"OG002","value":"38"}],"units":"Participants"}],"title":"Week 136 extension"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.86","value":"-1.4"},{"groupId":"OG001","spread":"0.99","value":"-1.5"},{"groupId":"OG002","spread":"0.84","value":"-1.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"28"},{"groupId":"OG001","value":"26"},{"groupId":"OG002","value":"36"}],"units":"Participants"}],"title":"Week 148 extension"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.90","value":"-1.4"},{"groupId":"OG001","spread":"0.87","value":"-1.6"},{"groupId":"OG002","spread":"0.94","value":"-1.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"29"},{"groupId":"OG001","value":"28"},{"groupId":"OG002","value":"34"}],"units":"Participants"}],"title":"Week 160 extension"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.81","value":"-1.5"},{"groupId":"OG001","spread":"0.97","value":"-1.6"},{"groupId":"OG002","spread":"0.98","value":"-1.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"26"},{"groupId":"OG001","value":"27"},{"groupId":"OG002","value":"31"}],"units":"Participants"}],"title":"Week 172 extension"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.70","value":"-1.3"},{"groupId":"OG001","spread":"1.03","value":"-1.5"},{"groupId":"OG002","spread":"0.93","value":"-1.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"23"},{"groupId":"OG001","value":"25"},{"groupId":"OG002","value":"31"}],"units":"Participants"}],"title":"Week 184 extension"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.81","value":"-1.4"},{"groupId":"OG001","spread":"1.11","value":"-1.5"},{"groupId":"OG002","spread":"1.11","value":"-1.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"23"},{"groupId":"OG001","value":"22"},{"groupId":"OG002","value":"29"}],"units":"Participants"}],"title":"Week 196 extension"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.79","value":"-1.4"},{"groupId":"OG001","spread":"1.00","value":"-1.6"},{"groupId":"OG002","spread":"0.98","value":"-1.2"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"23"},{"groupId":"OG001","value":"22"},{"groupId":"OG002","value":"22"}],"units":"Participants"}],"title":"Week 208 extension"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.94","value":"-1.4"},{"groupId":"OG001","spread":"1.06","value":"-1.6"},{"groupId":"OG002","spread":"0.91","value":"-1.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"20"},{"groupId":"OG001","value":"14"},{"groupId":"OG002","value":"20"}],"units":"Participants"}],"title":"Week 220 extension"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.92","value":"-1.4"},{"groupId":"OG001","spread":"1.13","value":"-1.5"},{"groupId":"OG002","spread":"0.82","value":"-1.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"15"},{"groupId":"OG001","value":"15"},{"groupId":"OG002","value":"15"}],"units":"Participants"}],"title":"Week 232 extension"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.75","value":"-1.3"},{"groupId":"OG001","spread":"1.12","value":"-1.9"},{"groupId":"OG002","spread":"0.79","value":"-1.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"12"},{"groupId":"OG001","value":"8"},{"groupId":"OG002","value":"11"}],"units":"Participants"}],"title":"Week 244 extension"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.58","value":"-1.3"},{"groupId":"OG001","spread":"1.39","value":"-1.4"},{"groupId":"OG002","spread":"0.90","value":"-1.8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"10"},{"groupId":"OG001","value":"6"},{"groupId":"OG002","value":"6"}],"units":"Participants"}],"title":"Week 256 extension"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.43","value":"-1.4"},{"groupId":"OG001","spread":"0.39","value":"-1.7"},{"groupId":"OG002","spread":"0.81","value":"-1.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"4"},{"groupId":"OG001","value":"3"},{"groupId":"OG002","value":"3"}],"units":"Participants"}],"title":"Week 268 extension"}],"denoms":[{"counts":[{"groupId":"OG000","value":"57"},{"groupId":"OG001","value":"54"},{"groupId":"OG002","value":"62"}],"units":"Participants"}],"description":"Change from CORE baseline at each scheduled assessment was performed for patients randomized to pasireotide arms. Change from extension baseline at each scheduled assessment was performed for patients randomized to active control arm. Standardized IGF-1 = IGF-1 value / ULN, where ULN is the upper limit of the normal range","dispersionType":"Standard Deviation","groups":[{"description":"If controlled on 40 mg in CORE, remain on blinded 40 mg in extension. If patient became uncontrolled, switch to open label 60 mg","id":"OG000","title":"Pasireotide LAR 40 mg Extension"},{"description":"If controlled on 60 mg in CORE, remain on blinded 60 mg in extension. If patient became uncontrolled, switch to open label 60 mg","id":"OG001","title":"Pasireotide LAR 60 mg Extension"},{"description":"Open - label 60 mg pasireotide. Control group from CORE discontinued study if controlled in CORE. If uncontrolled in CORE, switched to open label 60 mg pasireotide. Extension blinded 40 and 60 mg switched to open label if became uncontrolled.","id":"OG002","title":"Cross Over to Pasireotide Extension"}],"paramType":"MEAN","populationDescription":"Available data for analysis differed from visit to visit","reportingStatus":"POSTED","timeFrame":"CORE and extension baseline up to approximately 268 weeks","title":"Change From Baseline in Standardized IGF-1 Values for Patients Treated With Pasireotide LAR Alone or With Concomitant Medications Used to Treat Acromegaly for Extension Visits (Extension Full Analysis Set)","type":"SECONDARY","unitOfMeasure":"mcg/L"}