{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"24.90","value":"-7.9"},{"groupId":"OG001","spread":"14.88","value":"-6.9"},{"groupId":"OG002","spread":"49.64","value":"-8.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"44"},{"groupId":"OG001","value":"46"},{"groupId":"OG002","value":"57"}],"units":"Participants"}],"title":"Week 16 - extension"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"24.21","value":"-9.0"},{"groupId":"OG001","spread":"4.12","value":"-4.5"},{"groupId":"OG002","spread":"3.86","value":"-3.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"44"},{"groupId":"OG001","value":"39"},{"groupId":"OG002","value":"56"}],"units":"Participants"}],"title":"Week 28 - extension"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"25.40","value":"-9.7"},{"groupId":"OG001","spread":"13.93","value":"-5.8"},{"groupId":"OG002","spread":"58.28","value":"-11.2"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"38"},{"groupId":"OG001","value":"36"},{"groupId":"OG002","value":"50"}],"units":"Participants"}],"title":"Week 40 - extension"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"26.60","value":"-10.7"},{"groupId":"OG001","spread":"17.08","value":"-7.1"},{"groupId":"OG002","spread":"3.02","value":"-2.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"36"},{"groupId":"OG001","value":"35"},{"groupId":"OG002","value":"46"}],"units":"Participants"}],"title":"Week 52 - extension"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"28.37","value":"-11.3"},{"groupId":"OG001","spread":"17.30","value":"-7.9"},{"groupId":"OG002","spread":"76.06","value":"-15.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"37"},{"groupId":"OG001","value":"33"},{"groupId":"OG002","value":"39"}],"units":"Participants"}],"title":"Week 64 - extension"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"5.96","value":"-5.5"},{"groupId":"OG001","spread":"16.16","value":"-7.2"},{"groupId":"OG002","spread":"4.27","value":"-3.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"32"},{"groupId":"OG001","value":"36"},{"groupId":"OG002","value":"42"}],"units":"Participants"}],"title":"Week 76 - extension"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"6.21","value":"-5.7"},{"groupId":"OG001","spread":"8.55","value":"-6.2"},{"groupId":"OG002","spread":"3.22","value":"-3.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"32"},{"groupId":"OG001","value":"32"},{"groupId":"OG002","value":"40"}],"units":"Participants"}],"title":"Week 88 - extension"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"5.71","value":"-5.6"},{"groupId":"OG001","spread":"5.06","value":"-5.3"},{"groupId":"OG002","spread":"4.28","value":"-3.8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"34"},{"groupId":"OG001","value":"31"},{"groupId":"OG002","value":"39"}],"units":"Participants"}],"title":"Week 100 - extension"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"6.03","value":"-5.8"},{"groupId":"OG001","spread":"6.57","value":"-4.4"},{"groupId":"OG002","spread":"5.13","value":"-3.9"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"30"},{"groupId":"OG001","value":"32"},{"groupId":"OG002","value":"35"}],"units":"Participants"}],"title":"Week 112 - extension"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"5.85","value":"-5.5"},{"groupId":"OG001","spread":"6.26","value":"-6.0"},{"groupId":"OG002","spread":"4.36","value":"-4.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"30"},{"groupId":"OG001","value":"26"},{"groupId":"OG002","value":"35"}],"units":"Participants"}],"title":"Week 124 - extension"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"6.59","value":"-6.0"},{"groupId":"OG001","spread":"4.99","value":"-5.3"},{"groupId":"OG002","spread":"4.44","value":"-4.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"28"},{"groupId":"OG001","value":"26"},{"groupId":"OG002","value":"36"}],"units":"Participants"}],"title":"Week 136 - extension"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"6.21","value":"-6.3"},{"groupId":"OG001","spread":"6.28","value":"6.1"},{"groupId":"OG002","spread":"3.11","value":"-3.8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"29"},{"groupId":"OG001","value":"25"},{"groupId":"OG002","value":"35"}],"units":"Participants"}],"title":"Week 148 - extension"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"4.70","value":"-5.5"},{"groupId":"OG001","spread":"5.33","value":"-4.9"},{"groupId":"OG002","spread":"2.25","value":"-3.2"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"29"},{"groupId":"OG001","value":"26"},{"groupId":"OG002","value":"33"}],"units":"Participants"}],"title":"Week 160 - extension"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"6.34","value":"-6.3"},{"groupId":"OG001","spread":"5.97","value":"-5.9"},{"groupId":"OG002","spread":"2.47","value":"-3.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"27"},{"groupId":"OG001","value":"26"},{"groupId":"OG002","value":"31"}],"units":"Participants"}],"title":"Week 172 - extension"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"5.44","value":"-6.3"},{"groupId":"OG001","spread":"5.79","value":"-5.8"},{"groupId":"OG002","spread":"2.31","value":"-3.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"23"},{"groupId":"OG001","value":"25"},{"groupId":"OG002","value":"29"}],"units":"Participants"}],"title":"Week 184 - extension"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"6.81","value":"-7.1"},{"groupId":"OG001","spread":"7.17","value":"-6.5"},{"groupId":"OG002","spread":"2.71","value":"-3.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"22"},{"groupId":"OG001","value":"21"},{"groupId":"OG002","value":"29"}],"units":"Participants"}],"title":"Week 196 - extension"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"6.82","value":"-7.0"},{"groupId":"OG001","spread":"6.22","value":"-6.2"},{"groupId":"OG002","spread":"2.50","value":"-3.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"22"},{"groupId":"OG001","value":"20"},{"groupId":"OG002","value":"23"}],"units":"Participants"}],"title":"Week 208 - extension (n=22,20,23)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"6.91","value":"-7.1"},{"groupId":"OG001","spread":"8.12","value":"-7.1"},{"groupId":"OG002","spread":"2.48","value":"-3.8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"20"},{"groupId":"OG001","value":"14"},{"groupId":"OG002","value":"20"}],"units":"Participants"}],"title":"Week 220 - extension"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"5.46","value":"-5.7"},{"groupId":"OG001","spread":"8.10","value":"-6.8"},{"groupId":"OG002","spread":"2.46","value":"-4.2"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"16"},{"groupId":"OG001","value":"15"},{"groupId":"OG002","value":"14"}],"units":"Participants"}],"title":"Week 232 - extension"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"6.03","value":"-6.0"},{"groupId":"OG001","spread":"0.90","value":"-2.4"},{"groupId":"OG002","spread":"2.58","value":"-4.2"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"12"},{"groupId":"OG001","value":"7"},{"groupId":"OG002","value":"11"}],"units":"Participants"}],"title":"Week 244 - extension"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"5.91","value":"-6.4"},{"groupId":"OG001","spread":"3.49","value":"-4.9"},{"groupId":"OG002","spread":"3.26","value":"-5.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"10"},{"groupId":"OG001","value":"6"},{"groupId":"OG002","value":"6"}],"units":"Participants"}],"title":"Week 256 - extension"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"1.58","value":"-3.6"},{"groupId":"OG001","spread":"0.57","value":"-2.5"},{"groupId":"OG002","spread":"2.23","value":"-3.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"4"},{"groupId":"OG001","value":"3"},{"groupId":"OG002","value":"3"}],"units":"Participants"}],"title":"Week 268 - extension"}],"denoms":[{"counts":[{"groupId":"OG000","value":"57"},{"groupId":"OG001","value":"54"},{"groupId":"OG002","value":"62"}],"units":"Participants"}],"description":"Change from CORE baseline at each scheduled assessment was performed for patients randomized to pasireotide arms. Change from extension baseline at each scheduled assessment was performed for patients randomized to active control arm.","dispersionType":"Standard Deviation","groups":[{"description":"If controlled on 40 mg in CORE, remain on blinded 40 mg in extension. If patient became uncontrolled, switch to open label 60 mg","id":"OG000","title":"Pasireotide LAR 40 mg Extension"},{"description":"If controlled on 60 mg in CORE, remain on blinded 60 mg in extension. If patient became uncontrolled, switch to open label 60 mg","id":"OG001","title":"Pasireotide LAR 60 mg Extension"},{"description":"Open - label 60 mg pasireotide. Control group from CORE discontinued study if controlled in CORE. If uncontrolled in CORE, switched to open label 60 mg pasireotide. Extension blinded 40 and 60 mg switched to open label if became uncontrolled.","id":"OG002","title":"Cross Over to Pasireotide Extension"}],"paramType":"MEAN","populationDescription":"Available data for analysis differed from visit to visit","reportingStatus":"POSTED","timeFrame":"CORE and extension baseline up to approximately 268 weeks","title":"Change From Baseline in Mean GH Values for Patients Treated With Pasireotide LAR Alone or With Concomitant Medications Used to Treat Acromegaly for Extension Visits (Extension Full Analysis Set)","type":"SECONDARY","unitOfMeasure":"mcg/L"}