{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"10.05","upperLimit":"31.91","value":"19.3"},{"groupId":"OG001","lowerLimit":"14.96","upperLimit":"39.65","value":"25.9"},{"groupId":"OG002","lowerLimit":"10.42","upperLimit":"31.37","value":"19.4"}]}],"title":"Week 16"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"8.75","upperLimit":"29.91","value":"17.5"},{"groupId":"OG001","lowerLimit":"14.96","upperLimit":"39.65","value":"25.9"},{"groupId":"OG002","lowerLimit":"10.42","upperLimit":"31.37","value":"19.4"}]}],"title":"Week 28"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"11.38","upperLimit":"33.89","value":"21.1"},{"groupId":"OG001","lowerLimit":"16.46","upperLimit":"41.64","value":"27.8"},{"groupId":"OG002","lowerLimit":"9.20","upperLimit":"29.53","value":"17.7"}]}],"title":"Week 40"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"11.38","upperLimit":"33.89","value":"21.1"},{"groupId":"OG001","lowerLimit":"17.98","upperLimit":"43.61","value":"29.6"},{"groupId":"OG002","lowerLimit":"11.66","upperLimit":"33.18","value":"21.0"}]}],"title":"Week 52"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"12.74","upperLimit":"35.84","value":"22.8"},{"groupId":"OG001","lowerLimit":"10.63","upperLimit":"33.53","value":"20.4"},{"groupId":"OG002","lowerLimit":"15.53","upperLimit":"38.50","value":"25.8"}]}],"title":"Week 64"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"11.38","upperLimit":"33.89","value":"21.1"},{"groupId":"OG001","lowerLimit":"17.98","upperLimit":"43.61","value":"29.6"},{"groupId":"OG002","lowerLimit":"16.85","upperLimit":"40.23","value":"27.4"}]}],"title":"Week 76"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"14.13","upperLimit":"37.76","value":"24.6"},{"groupId":"OG001","lowerLimit":"19.52","upperLimit":"45.55","value":"31.5"},{"groupId":"OG002","lowerLimit":"15.53","upperLimit":"38.50","value":"25.8"}]}],"title":"Week 88"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"14.13","upperLimit":"37.76","value":"24.6"},{"groupId":"OG001","lowerLimit":"13.49","upperLimit":"37.64","value":"24.1"},{"groupId":"OG002","lowerLimit":"20.94","upperLimit":"45.34","value":"32.3"}]}],"title":"Week 100"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"14.13","upperLimit":"37.76","value":"24.6"},{"groupId":"OG001","lowerLimit":"14.96","upperLimit":"39.65","value":"25.9"},{"groupId":"OG002","lowerLimit":"15.53","upperLimit":"38.50","value":"25.8"}]}],"title":"Week 112"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"11.38","upperLimit":"33.89","value":"21.1"},{"groupId":"OG001","lowerLimit":"13.49","upperLimit":"37.64","value":"24.1"},{"groupId":"OG002","lowerLimit":"15.53","upperLimit":"38.50","value":"25.8"}]}],"title":"Week 124"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"7.48","upperLimit":"27.87","value":"15.8"},{"groupId":"OG001","lowerLimit":"13.49","upperLimit":"37.64","value":"24.1"},{"groupId":"OG002","lowerLimit":"18.20","upperLimit":"41.95","value":"29.0"}]}],"title":"Week 136"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"11.38","upperLimit":"33.89","value":"21.1"},{"groupId":"OG001","lowerLimit":"10.63","upperLimit":"33.53","value":"20.4"},{"groupId":"OG002","lowerLimit":"18.20","upperLimit":"41.95","value":"29.0"}]}],"title":"Week 148"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"10.05","upperLimit":"31.91","value":"19.3"},{"groupId":"OG001","lowerLimit":"10.63","upperLimit":"33.53","value":"20.4"},{"groupId":"OG002","lowerLimit":"19.56","upperLimit":"43.65","value":"30.6"}]}],"title":"Week 160"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"12.74","upperLimit":"35.84","value":"22.8"},{"groupId":"OG001","lowerLimit":"10.63","upperLimit":"33.53","value":"20.4"},{"groupId":"OG002","lowerLimit":"11.66","upperLimit":"33.18","value":"21.0"}]}],"title":"Week 172"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"8.75","upperLimit":"29.91","value":"17.5"},{"groupId":"OG001","lowerLimit":"10.63","upperLimit":"33.53","value":"20.4"},{"groupId":"OG002","lowerLimit":"9.20","upperLimit":"29.53","value":"17.7"}]}],"title":"Week 184"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"7.48","upperLimit":"27.87","value":"15.8"},{"groupId":"OG001","lowerLimit":"10.63","upperLimit":"33.53","value":"20.4"},{"groupId":"OG002","lowerLimit":"14.22","upperLimit":"36.74","value":"24.2"}]}],"title":"Week 196"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"8.75","upperLimit":"29.91","value":"17.5"},{"groupId":"OG001","lowerLimit":"9.25","upperLimit":"31.43","value":"18.5"},{"groupId":"OG002","lowerLimit":"10.42","upperLimit":"31.37","value":"19.4"}]}],"title":"Week 208"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"11.38","upperLimit":"33.89","value":"21.1"},{"groupId":"OG001","lowerLimit":"4.19","upperLimit":"22.63","value":"11.1"},{"groupId":"OG002","lowerLimit":"6.86","upperLimit":"25.78","value":"14.5"}]}],"title":"Week 220"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"6.26","upperLimit":"25.79","value":"14.0"},{"groupId":"OG001","lowerLimit":"6.62","upperLimit":"27.12","value":"14.8"},{"groupId":"OG002","lowerLimit":"6.86","upperLimit":"25.78","value":"14.5"}]}],"title":"Week 232"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"6.26","upperLimit":"25.79","value":"14.0"},{"groupId":"OG001","lowerLimit":"2.06","upperLimit":"17.89","value":"7.4"},{"groupId":"OG002","lowerLimit":"4.66","upperLimit":"21.89","value":"11.3"}]}],"title":"Week 244"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"3.96","upperLimit":"21.52","value":"10.5"},{"groupId":"OG001","lowerLimit":"2.06","upperLimit":"17.89","value":"7.4"},{"groupId":"OG002","lowerLimit":"0.39","upperLimit":"11.17","value":"3.2"}]}],"title":"Week 256"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1.10","upperLimit":"14.62","value":"5.3"},{"groupId":"OG001","lowerLimit":"1.16","upperLimit":"15.39","value":"5.6"},{"groupId":"OG002","lowerLimit":"0.04","upperLimit":"8.66","value":"1.6"}]}],"title":"Week 268"}],"denoms":[{"counts":[{"groupId":"OG000","value":"57"},{"groupId":"OG001","value":"54"},{"groupId":"OG002","value":"62"}],"units":"Participants"}],"description":"The percentage of patients achieving mean growth hormone (GH) levels \\< 2.5 μg/L and normalization of sex and age-adjusted IGF-1 was calculated with two sided 95% confidence interval. All GH assessments were based on a 5-point mean growth hormone (GH) assessed from a 2-hour profile. Scheduled time points for blood sampling were pre-dose at 0, 30, 60, 90 and 120 minutes. Total insulin-like growth factor (IGF-1) levels were assessed with one pre-dose sample at the same visits as GH. Concomitant medication known to affect GH or IGF-1 levels were allowed in patients who were not biochemically controlled after at least one year treatment with pasireotide LAR monotherapy: dopamine agonists and growth hormone receptor antagonists (extension full analysis set)","dispersionType":"95% Confidence Interval","groups":[{"description":"If controlled on 40 mg in CORE, remain on blinded 40 mg in extension. If patient became uncontrolled, switch to open label 60 mg","id":"OG000","title":"Pasireotide LAR 40 mg Extension"},{"description":"If controlled on 60 mg in CORE, remain on blinded 60 mg in extension. If patient became uncontrolled, switch to open label 60 mg","id":"OG001","title":"Pasireotide LAR 60 mg Extension"},{"description":"Open - label 60 mg pasireotide. Control group from CORE discontinued study if controlled in CORE. If uncontrolled in CORE, switched to open label 60 mg pasireotide. Extension blinded 40 and 60 mg switched to open label if became uncontrolled.","id":"OG002","title":"Cross Over to Pasireotide Extension"}],"paramType":"NUMBER","reportingStatus":"POSTED","timeFrame":"Extension baseline up to approximately week 268","title":"Percentage of Patients With Mean GH < 2.5 μg/L and Normalization of IGF-1, Treated With Pasireotide LAR Alone or With Concomitant Medications Used to Treat Acromegaly (Extension Full Analysis Set)","type":"SECONDARY","unitOfMeasure":"percentage of participants"}