{"denoms":[{"counts":[{"groupId":"BG000","value":"125"},{"groupId":"BG001","value":"213"},{"groupId":"BG002","value":"52"},{"groupId":"BG003","value":"11"},{"groupId":"BG004","value":"401"}],"units":"Participants"}],"groups":[{"description":"Hyperfractionated total body irradiation to a dose of 1375-1500 cGy (depending on age, stage of disease and requirement of general anesthesia) with lung shielding) Thiotepa (5 mg/kg/day x 2 or 10 mg/kg/day x 1) Cyclophosphamide (60 mg/kg/day x 2) (or fludarabine 25mg/m2 x 5 if cyclophosphamide is contraindicated)\n\ntotal body irradiation: dose of 1375-1500 cGy\n\nThiotepa: 5 mg/kg/day x 2 or 10 mg/kg/day x 1\n\nCyclophosphamide: 60 mg/ kg/day x 2 (or fludarabine 25mg/m2 x 5 if cyclophosphamide is contraindicated).\n\n(CliniMACS) T-cell depleted PBSC Transplant","id":"BG000","title":"Total Body Irradiation, Thiotepa and Cyclophosphamide"},{"description":"Busulfan (0.8 mg/kg every 6 hours x 10 or 12 doses), (depending on disease) with dose modified according to pharmacokinetics Melphalan (70mg/m2/day x 2 ) Fludarabine (25mg/m2/ day x 5)\n\nBusulfan: 0.8 mg/kg every 6 hours x 10 or 12 doses (depending on disease) with dose modified according to pharmacokinetics\n\nMelphalan: 70mg/m2/day x 2\n\nFludarabine: 25mg/m2/ day x 5\n\n(CliniMACS) T-cell depleted PBSC Transplant","id":"BG001","title":"Busulfan, Melphalan and Fludarabine"},{"description":"Clofarabine (20mg/m2/ day x 5) (or, for children \\<18 years of age, 30mg/m2/day x 5 if deemed suitable and with PI approval), Melphalan (70 mg/m2/day x 2) Thiotepa (5 mg/kg/day x 2 or 10mg/kg/day x1)\n\nThiotepa: 5 mg/kg/day x 2 or 10 mg/kg/day x 1\n\nMelphalan: 70mg/m2/day x 2\n\nClofarabine: 20mg/m2/ day x 5 (or, for children \\<18 years of age, 30mg/m2/day x 5 if deemed suitable and with PI approval)\n\n(CliniMACS) T-cell depleted PBSC Transplant","id":"BG002","title":"Clofarabine, Melphalan and Thiotepa"},{"description":"Melphalan (70 mg/m2/day x 2) Fludarabine (25mg/m2/ day x 5 ) Thiotepa (5 mg/kg/day x 2 or 10mg/kg/day x1)\n\nThiotepa: 5 mg/kg/day x 2 or 10 mg/kg/day x 1\n\nMelphalan: 70mg/m2/day x 2\n\n(CliniMACS) T-cell depleted PBSC Transplant","id":"BG003","title":"Melphalan, Fludarabine and Thiotepa"},{"description":"Total of all reporting groups","id":"BG004","title":"Total"}],"measures":[{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","lowerLimit":"3.5","upperLimit":"63.9","value":"30.3"},{"groupId":"BG001","lowerLimit":"2","upperLimit":"73","value":"57.6"},{"groupId":"BG002","lowerLimit":"0.6","upperLimit":"67.2","value":"28.1"},{"groupId":"BG003","lowerLimit":"0.8","upperLimit":"67.2","value":"10"},{"groupId":"BG004","lowerLimit":"0.6","upperLimit":"73","value":"48"}]}]}],"dispersionType":"FULL_RANGE","paramType":"MEDIAN","title":"Age, Continuous","unitOfMeasure":"years"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","value":"63"},{"groupId":"BG001","value":"91"},{"groupId":"BG002","value":"21"},{"groupId":"BG003","value":"5"},{"groupId":"BG004","value":"180"}],"title":"Female"},{"measurements":[{"groupId":"BG000","value":"62"},{"groupId":"BG001","value":"122"},{"groupId":"BG002","value":"31"},{"groupId":"BG003","value":"6"},{"groupId":"BG004","value":"221"}],"title":"Male"}]}],"paramType":"COUNT_OF_PARTICIPANTS","title":"Sex: Female, Male","unitOfMeasure":"Participants"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","value":"18"},{"groupId":"BG001","value":"10"},{"groupId":"BG002","value":"6"},{"groupId":"BG003","value":"4"},{"groupId":"BG004","value":"38"}],"title":"Hispanic or Latino"},{"measurements":[{"groupId":"BG000","value":"64"},{"groupId":"BG001","value":"145"},{"groupId":"BG002","value":"30"},{"groupId":"BG003","value":"5"},{"groupId":"BG004","value":"244"}],"title":"Not Hispanic or Latino"},{"measurements":[{"groupId":"BG000","value":"43"},{"groupId":"BG001","value":"58"},{"groupId":"BG002","value":"16"},{"groupId":"BG003","value":"2"},{"groupId":"BG004","value":"119"}],"title":"Unknown or Not Reported"}]}],"paramType":"COUNT_OF_PARTICIPANTS","title":"Ethnicity (NIH/OMB)","unitOfMeasure":"Participants"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","value":"1"},{"groupId":"BG001","value":"0"},{"groupId":"BG002","value":"0"},{"groupId":"BG003","value":"0"},{"groupId":"BG004","value":"1"}],"title":"American Indian or Alaska Native"},{"measurements":[{"groupId":"BG000","value":"9"},{"groupId":"BG001","value":"13"},{"groupId":"BG002","value":"5"},{"groupId":"BG003","value":"2"},{"groupId":"BG004","value":"29"}],"title":"Asian"},{"measurements":[{"groupId":"BG000","value":"0"},{"groupId":"BG001","value":"0"},{"groupId":"BG002","value":"0"},{"groupId":"BG003","value":"0"},{"groupId":"BG004","value":"0"}],"title":"Native Hawaiian or Other Pacific Islander"},{"measurements":[{"groupId":"BG000","value":"13"},{"groupId":"BG001","value":"17"},{"groupId":"BG002","value":"1"},{"groupId":"BG003","value":"2"},{"groupId":"BG004","value":"33"}],"title":"Black or African American"},{"measurements":[{"groupId":"BG000","value":"94"},{"groupId":"BG001","value":"176"},{"groupId":"BG002","value":"41"},{"groupId":"BG003","value":"6"},{"groupId":"BG004","value":"317"}],"title":"White"},{"measurements":[{"groupId":"BG000","value":"0"},{"groupId":"BG001","value":"0"},{"groupId":"BG002","value":"0"},{"groupId":"BG003","value":"0"},{"groupId":"BG004","value":"0"}],"title":"More than one race"},{"measurements":[{"groupId":"BG000","value":"8"},{"groupId":"BG001","value":"7"},{"groupId":"BG002","value":"5"},{"groupId":"BG003","value":"1"},{"groupId":"BG004","value":"21"}],"title":"Unknown or Not Reported"}]}],"paramType":"COUNT_OF_PARTICIPANTS","title":"Race (NIH/OMB)","unitOfMeasure":"Participants"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","value":"125"},{"groupId":"BG001","value":"213"},{"groupId":"BG002","value":"52"},{"groupId":"BG003","value":"11"},{"groupId":"BG004","value":"401"}]}],"title":"United States"}],"paramType":"COUNT_OF_PARTICIPANTS","title":"Region of Enrollment","unitOfMeasure":"Participants"}]}