{"analyses":[{"ciLowerLimit":"0.004","ciNumSides":"TWO_SIDED","ciPctValue":"95","ciUpperLimit":"0.479","groupDescription":"Pre-specified","groupIds":["OG000","OG001"],"nonInferiorityType":"SUPERIORITY","pValue":"=0.0001","pValueComment":"Cox regression HR: 0.0105","paramType":"Hazard Ratio (HR)","paramValue":"0.043","statisticalMethod":"Log Rank"}],"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"3.2","upperLimit":"6.2","value":"5.1"},{"comment":"not reached","groupId":"OG001","lowerLimit":"NA","upperLimit":"NA","value":"0.9"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"51"},{"groupId":"OG001","value":"1"}],"units":"Participants"}],"description":"DR was calculated from the date of first documentation of response to the date of disease progression or death. Progression is defined using Response Evaluation Criteria In Solid Tumors Criteria (RECIST v1.0), as a 20% increase in the sum of the longest diameter of target lesions, or a measurable increase in a non-target lesion, or the appearance of new lesions","dispersionType":"95% Confidence Interval","groups":[{"description":"plitidepsin + dexamethasone combination\n\nplitidepsin + dexamethasone: plitidepsin: powder and solvent for concentrate for solution for infusion. 2 mg vial + 4 ml ampoule. 5 mg/m2 intravenously (i.v.) over three hours on Day 1 and 15 every 4 weeks. dexamethasone: 4 mg tablet. 40 mg orally on Day 1, 8, 15 and 22 every four weeks at least one hour before plitidepsin infusion.","id":"OG000","title":"Plitidepsin+Dexamethasone"},{"description":"dexamethasone single agent\n\ndexamethasone: 4 mg tablet. 40 mg orally on Day 1, 8, 15 and 22 every four weeks.","id":"OG001","title":"Dexamethasone"}],"paramType":"MEDIAN","populationDescription":"Patients with documentation of response","reportingStatus":"POSTED","timeFrame":"From the date of first documentation of response to the date of disease progression or death, assessed up to 5 years","title":"Duration of Response (Investigator Assessment)","type":"SECONDARY","unitOfMeasure":"months"}