{"analyses":[{"ciLowerLimit":"0.284","ciNumSides":"TWO_SIDED","ciPctValue":"95","ciUpperLimit":"1.053","estimateComment":"Hazard ratio is based on hazard of death for Arm II over death of events for Arm III.","groupDescription":"In stratum 1, it was also planned to test the superiority of RT+maintenance vs. RT alone as measured by OS using the hazard ratio via a 2-sided log-rank test. A two-sided significance threshold of 5% was planned for this comparison.","groupIds":["OG000","OG001"],"nonInferiorityType":"SUPERIORITY","pValue":"0.067","pValueComment":"P-value is two-sided and not adjusted for multiple comparisons for this exploratory subgroup comparison.","paramType":"Hazard Ratio (HR)","paramValue":"0.547","statisticalMethod":"Log Rank"}],"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"84.2","upperLimit":"94.7","value":"90.7"},{"groupId":"OG001","lowerLimit":"78.5","upperLimit":"91.5","value":"86.4"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"144"},{"groupId":"OG001","value":"142"}],"units":"Participants"}],"description":"Kaplan-Meier estimates of OS are calculated from randomization date to death from any cause. The comparison between randomized arms (post-radiation maintenance chemotherapy versus post-radiation observation only) for this stratum is conveyed by the hazard ratio and 95% Wald confidence interval.","dispersionType":"95% Confidence Interval","groups":[{"description":"Patients with supratentorial ependymoma (Grade II without GTR1 or Grade III) or any infratentorial ependymoma who have undergone gross or near total resection (GTR or NTR) after initial surgery (stratum 1) are randomized to undergo conformal radiotherapy over 6-7 weeks followed by maintenance chemotherapy.","id":"OG000","title":"Arm II: Randomized to Radiation With Maintenance Chemotherapy in Stratum 1"},{"description":"Patients with supratentorial ependymoma (Grade II without GTR1 or ST Grade III) or any infratentorial ependymoma (Grade II or III) who have undergone gross or near total resection after initial surgery (stratum 1) are randomized to undergo conformal radiotherapy over 6-7 weeks and then undergo observation.","id":"OG001","title":"Arm III: Randomized to Radiation Only in Stratum 1"}],"paramType":"NUMBER","populationDescription":"Eligible, randomized participants (intent-to-treat) in stratum 1 (completely resected ependymom at initial surgery)","reportingStatus":"POSTED","timeFrame":"Up to 10 years after enrollment. 5-year estimates of OS are presented.","title":"OS in Children Who Have Completely Resected Ependymoma at Initial Surgery and Are Treated With Post-radiation Maintenance Chemotherapy or Post-radiation Observation Only.","type":"OTHER_PRE_SPECIFIED","unitOfMeasure":"percentage of participants"}