{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1.50","upperLimit":"4.00","value":"3.00"},{"groupId":"OG001","lowerLimit":"2.00","upperLimit":"6.18","value":"3.51"},{"groupId":"OG002","lowerLimit":"2.00","upperLimit":"6.02","value":"3.00"},{"groupId":"OG003","lowerLimit":"1.50","upperLimit":"10.00","value":"2.07"}]}],"title":"GSK2285403, Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1.50","upperLimit":"3.00","value":"2.00"},{"groupId":"OG001","lowerLimit":"1.42","upperLimit":"3.00","value":"2.00"},{"groupId":"OG002","lowerLimit":"1.47","upperLimit":"4.00","value":"2.00"},{"groupId":"OG003","lowerLimit":"1.00","upperLimit":"3.98","value":"2.00"}]}],"title":"GSK2285403, Day 21"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"5.98","upperLimit":"10.1","value":"10.0"},{"groupId":"OG001","lowerLimit":"4.00","upperLimit":"24.0","value":"8.93"},{"groupId":"OG002","lowerLimit":"6.00","upperLimit":"24.0","value":"10.0"},{"groupId":"OG003","lowerLimit":"4.07","upperLimit":"24.0","value":"8.00"}]}],"title":"GSK2298683, Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"3.00","upperLimit":"8.00","value":"5.00"},{"groupId":"OG001","lowerLimit":"3.00","upperLimit":"6.00","value":"4.00"},{"groupId":"OG002","lowerLimit":"2.00","upperLimit":"10.00","value":"5.98"},{"groupId":"OG003","lowerLimit":"3.00","upperLimit":"6.08","value":"4.00"}]}],"title":"GSK2298683, Day 21"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"8.00","upperLimit":"24.1","value":"24.0"},{"groupId":"OG001","lowerLimit":"6.00","upperLimit":"24.6","value":"24.0"},{"groupId":"OG002","lowerLimit":"23.5","upperLimit":"25.0","value":"24.0"},{"groupId":"OG003","lowerLimit":"10.0","upperLimit":"24.3","value":"24.0"}]}],"title":"GSK2167542, Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"0","upperLimit":"10.0","value":"0.75"},{"groupId":"OG001","lowerLimit":"0.50","upperLimit":"10.0","value":"2.00"},{"groupId":"OG002","lowerLimit":"1.00","upperLimit":"10.00","value":"2.00"},{"groupId":"OG003","lowerLimit":"0","upperLimit":"9.92","value":"1.75"}]}],"title":"GSK2167542, Day 21"}],"denoms":[{"counts":[{"groupId":"OG000","value":"15"},{"groupId":"OG001","value":"14"},{"groupId":"OG002","value":"15"},{"groupId":"OG003","value":"15"}],"units":"Participants"}],"description":"The time to Cmax (tmax) of DAB metabolites hydroxy-dabrafenib (GSK2285403), carboxy-dabrafenib (GSK2298683) and desmethyl-dabrafenib (GSK2167542) after single and repeat doses of DAB alone and in combination with trametinib was measuered at Day 1 and Day 21.","dispersionType":"Full Range","groups":[{"description":"Participants received dabrefinib 75 mg HPMC capsules BID. These participants, after completion of serial PK collection in the first treatment period, were allowed to continue with dabrafenib 75 mg BID and trametinib 2 mg tablets QD as combination dosing starting on Day 29.","id":"OG000","title":"Part D: Dabrafenib (DAB) 75 mg to DAB 75 mg + Trametinib 2 mg"},{"description":"Participants received dabrefinib 150 mg HPMC capsules BID. These participants, after completion of serial PK collection in the first treatment period, were allowed to continue with dabrafenib 150 mg BID and trametinib 2 mg tablets QD as combination dosing starting on Day 29.","id":"OG001","title":"Part D: Dabrafenib 150 mg to DAB 150 mg + Trametinib 2 mg"},{"description":"Participants received dabrefinib 75 mg HPMC capsules BID and trametinib 2 mg tablets QD.","id":"OG002","title":"Part D: Dabrafenib 75 mg + Trametinib 2 mg"},{"description":"Participants received dabrefinib 150 mg HPMC capsules BID and trametinib 2 mg tablets QD.","id":"OG003","title":"Part D: Dabrafenib 150 mg + Trametinib 2 mg"}],"paramType":"MEDIAN","populationDescription":"PK Population. Only participants who were available at the indicated timepoints were analyzed.","reportingStatus":"POSTED","timeFrame":"Day 1: pre-dose, and 0.5, 1, 1.5, 2, 3, 4, 6, 8, 10, and 24 hours post dose. Day 21: pre-dose and 0.5, 1, 1.5, 2, 3, 4, 6, 8, and 10 hours post-dose","title":"Part D: Tmax of Dabrafenib Metabolites","type":"SECONDARY","unitOfMeasure":"Hours"}