{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"0","upperLimit":"0","value":"0"},{"groupId":"OG001","lowerLimit":"3.4","upperLimit":"11.3","value":"5.86"},{"groupId":"OG002","lowerLimit":"4.8","upperLimit":"26.00","value":"9.35"}]}],"title":"Day 15"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"0","upperLimit":"13.9","value":"0"},{"groupId":"OG001","lowerLimit":"2.0","upperLimit":"9.6","value":"6.70"},{"groupId":"OG002","lowerLimit":"0","upperLimit":"25.8","value":"10.3"}]}],"title":"Week 8"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"0","upperLimit":"9.8","value":"0"},{"groupId":"OG001","lowerLimit":"0","upperLimit":"20.7","value":"6.99"},{"groupId":"OG002","lowerLimit":"1.1","upperLimit":"25.4","value":"9.87"}]}],"title":"Week 16"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"0","upperLimit":"19.7","value":"0"},{"groupId":"OG001","lowerLimit":"0","upperLimit":"11.2","value":"5.99"},{"groupId":"OG002","lowerLimit":"0.5","upperLimit":"27.4","value":"9.54"}]}],"title":"Week 24"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"0","upperLimit":"0","value":"0"},{"groupId":"OG001","lowerLimit":"0.7","upperLimit":"11.6","value":"5.77"},{"groupId":"OG002","lowerLimit":"0","upperLimit":"51.5","value":"9.74"}]}],"title":"Week 32"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"0","upperLimit":"0","value":"0"},{"groupId":"OG001","lowerLimit":"2.2","upperLimit":"16.7","value":"7.11"},{"groupId":"OG002","lowerLimit":"0","upperLimit":"26.4","value":"10.1"}]}],"title":"Week 40"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"0","upperLimit":"0","value":"0"},{"groupId":"OG001","lowerLimit":"0","upperLimit":"14.3","value":"5.62"},{"groupId":"OG002","lowerLimit":"0","upperLimit":"35.6","value":"10.3"}]}],"title":"Week 48"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"0","upperLimit":"0","value":"0"},{"groupId":"OG001","lowerLimit":"3.4","upperLimit":"16.9","value":"9.90"},{"groupId":"OG002","lowerLimit":"0","upperLimit":"15.4","value":"8.60"}]}],"title":"Week 56"}],"denoms":[{"counts":[{"groupId":"OG000","value":"59"},{"groupId":"OG001","value":"53"},{"groupId":"OG002","value":"50"}],"units":"Participants"}],"description":"Plasma concentrations of trametinib was assessed following daily dose of dabrafenib and trametinib.","dispersionType":"Full Range","groups":[{"description":"Participants received dabrafenib 150 mg gelatin capsules BID.","id":"OG000","title":"Part C: Dabrafenib 150 mg"},{"description":"Participants received dabrafenib 150 mg gelatin capsules BID and trametinib 1 mg tablets QD.","id":"OG001","title":"Part C: Dabrafenib 150 mg + Trametinib 1 mg"},{"description":"Participants received dabrafenib 150 mg gelatin capsules BID and trametinib 2 mg tablets QD.","id":"OG002","title":"Part C: Dabrafenib 150 mg + Trametinib 2 mg"}],"paramType":"MEDIAN","populationDescription":"PK Population. Only those participants who were available at the indicated time points were analyzed.","reportingStatus":"POSTED","timeFrame":"Day 15, Week 8, Week 16, Week 24, Week 32, Week 40, Week 48, and Week 56","title":"Part C: Plasma Concentrations of Trametinib","type":"SECONDARY","unitOfMeasure":"ng/mL"}