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GSK2298683"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"21","upperLimit":"9952","value":"3497.9"},{"groupId":"OG001","lowerLimit":"0","upperLimit":"8782","value":"2946.1"},{"groupId":"OG002","lowerLimit":"44","upperLimit":"14004","value":"2756.5"}]}],"title":"Week 16, GSK2298683"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"500","upperLimit":"8635","value":"2876.5"},{"groupId":"OG001","lowerLimit":"25","upperLimit":"7482","value":"3365.4"},{"groupId":"OG002","lowerLimit":"133","upperLimit":"6531","value":"3193.7"}]}],"title":"Week 24, GSK2298683"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"447","upperLimit":"14341","value":"2699.9"},{"groupId":"OG001","lowerLimit":"0","upperLimit":"9278","value":"3267.1"},{"groupId":"OG002","lowerLimit":"50","upperLimit":"9077","value":"3046.8"}]}],"title":"Week 32, GSK2298683"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1023","upperLimit":"14258","value":"4410.6"},{"groupId":"OG001","lowerLimit":"1900","upperLimit":"7663","value":"3694.7"},{"groupId":"OG002","lowerLimit":"0","upperLimit":"12550","value":"3492.8"}]}],"title":"Week 40, GSK2298683"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1889","upperLimit":"7148","value":"3554.9"},{"groupId":"OG001","lowerLimit":"0","upperLimit":"8351","value":"4146.9"},{"groupId":"OG002","lowerLimit":"464","upperLimit":"12239","value":"3936.1"}]}],"title":"Week 48, GSK2298683"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1102","upperLimit":"2963","value":"2032.2"},{"groupId":"OG001","lowerLimit":"374","upperLimit":"6866","value":"3843.5"},{"groupId":"OG002","lowerLimit":"1305","upperLimit":"4673","value":"2904.9"}]}],"title":"Week 56, GSK2298683"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"95","upperLimit":"955","value":"247.9"},{"groupId":"OG001","lowerLimit":"49","upperLimit":"1164","value":"288"},{"groupId":"OG002","lowerLimit":"72","upperLimit":"1140","value":"289.3"}]}],"title":"Day 15, GSK2167542"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"19","upperLimit":"1092","value":"239.5"},{"groupId":"OG001","lowerLimit":"3","upperLimit":"983","value":"275.2"},{"groupId":"OG002","lowerLimit":"0","upperLimit":"9876","value":"262.4"}]}],"title":"Week 8, GSK2167542"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1","upperLimit":"772","value":"244"},{"groupId":"OG001","lowerLimit":"0","upperLimit":"922","value":"204.4"},{"groupId":"OG002","lowerLimit":"3","upperLimit":"1049","value":"243.8"}]}],"title":"Week 16, GSK2167542"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"48","upperLimit":"899","value":"225.6"},{"groupId":"OG001","lowerLimit":"4","upperLimit":"990","value":"247.2"},{"groupId":"OG002","lowerLimit":"3","upperLimit":"846","value":"254.6"}]}],"title":"Week 24, GSK2167542"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"19","upperLimit":"544","value":"171"},{"groupId":"OG001","lowerLimit":"0","upperLimit":"698","value":"255.4"},{"groupId":"OG002","lowerLimit":"2","upperLimit":"962","value":"289.3"}]}],"title":"Week 32, GSK2167542"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"95","upperLimit":"639","value":"222.2"},{"groupId":"OG001","lowerLimit":"55","upperLimit":"674","value":"249.3"},{"groupId":"OG002","lowerLimit":"0","upperLimit":"910","value":"268.9"}]}],"title":"Week 40, GSK2167542"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"145","upperLimit":"286","value":"204.5"},{"groupId":"OG001","lowerLimit":"0","upperLimit":"915","value":"232"},{"groupId":"OG002","lowerLimit":"81","upperLimit":"886","value":"260.9"}]}],"title":"Week 48, GSK2167542"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"116","upperLimit":"228","value":"171.8"},{"groupId":"OG001","lowerLimit":"28","upperLimit":"851","value":"250"},{"groupId":"OG002","lowerLimit":"107","upperLimit":"663","value":"462.1"}]}],"title":"Week 56, GSK2167542"}],"denoms":[{"counts":[{"groupId":"OG000","value":"49"},{"groupId":"OG001","value":"53"},{"groupId":"OG002","value":"50"}],"units":"Participants"}],"description":"Plasma concentrations of dabrafenib and its metabolites hydroxy-dabrafenib (GSK2285403), carboxy-dabrafenib (GSK2298683) and desmethyl-dabrafenib (GSK2167542) were assesed following daily dose of dabrafenib and trametinib.","dispersionType":"Full 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Only those participants who were available at the indicated time points were analyzed.","reportingStatus":"POSTED","timeFrame":"Day 15, Week 8, Week 16, Week 24, Week 32, Week 40, Week 48, and Week 56","title":"Part C: Plasma Concentrations of Dabrafenib and Its Metabolites","type":"SECONDARY","unitOfMeasure":"ng/mL"}