{"groups":[{"description":"Patients receive 25mg aurora A kinase inhibitor MLN8237 once daily on days 1-14 and 1.3mg Bortezomib on days 1, 4,8, and 11.\n\nAurora A kinase inhibitor MLN8237: Given orally bortezomib: Given IV","id":"FG000","title":"Phase I, Dose 0**"},{"description":"Patients receive 20mg aurora A kinase inhibitor MLN8237 twice daily on days 1-7 and 1.5mg Bortezomib on days 1, 8,15, and 22.\n\nAurora A kinase inhibitor MLN8237: Given orally bortezomib: Given IV","id":"FG001","title":"Phase I, Dose 0"},{"description":"Patients receive 30mg aurora A kinase inhibitor MLN8237 twice daily on days 1-7 and 1.5mg Bortezomib on days 1, 8,15, and 22.\n\nAurora A kinase inhibitor MLN8237: Given orally bortezomib: Given IV","id":"FG002","title":"Phase I, Dose 1"},{"description":"Patients receive 40mg aurora A kinase inhibitor MLN8237 twice daily on days 1-7 and 1.5mg Bortezomib on days 1, 8,15, and 22.\n\nAurora A kinase inhibitor MLN8237: Given orally bortezomib: Given IV","id":"FG003","title":"Phase I, Dose 2"},{"description":"Patients receive 50mg aurora A kinase inhibitor MLN8237 twice daily on days 1-7 and 1.5mg Bortezomib on days 1, 8,15, and 22.\n\nAurora A kinase inhibitor MLN8237: Given orally bortezomib: Given IV","id":"FG004","title":"Phase I, Dose 3"},{"description":"Patients receive 50mg aurora A kinase inhibitor MLN8237 twice daily on days 1-7 and 1.5mg Bortezomib on days 1, 8,15, and 22.\n\n\\>\n\n\\> Aurora A kinase inhibitor MLN8237: Given orally\n\n\\>\n\n\\> bortezomib: Given IV","id":"FG005","title":"Phase II, Dose 3"}],"periods":[{"milestones":[{"achievements":[{"groupId":"FG000","numSubjects":"3"},{"groupId":"FG001","numSubjects":"4"},{"groupId":"FG002","numSubjects":"3"},{"groupId":"FG003","numSubjects":"3"},{"groupId":"FG004","numSubjects":"6"},{"groupId":"FG005","numSubjects":"7"}],"type":"STARTED"},{"achievements":[{"groupId":"FG000","numSubjects":"3"},{"groupId":"FG001","numSubjects":"4"},{"groupId":"FG002","numSubjects":"3"},{"groupId":"FG003","numSubjects":"3"},{"groupId":"FG004","numSubjects":"6"},{"groupId":"FG005","numSubjects":"7"}],"type":"COMPLETED"},{"achievements":[{"groupId":"FG000","numSubjects":"0"},{"groupId":"FG001","numSubjects":"0"},{"groupId":"FG002","numSubjects":"0"},{"groupId":"FG003","numSubjects":"0"},{"groupId":"FG004","numSubjects":"0"},{"groupId":"FG005","numSubjects":"0"}],"type":"NOT COMPLETED"}],"title":"Overall Study"}]}