{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","value":"42"}]}],"title":"% of patients that achieve at least a sCR"},{"categories":[{"measurements":[{"groupId":"OG000","value":"81"}]}],"title":"% of patients that achieve at least a VGPR"},{"categories":[{"measurements":[{"groupId":"OG000","value":"98"}]}],"title":"% of patients that achieve at least a PR"}],"denoms":[{"counts":[{"groupId":"OG000","value":"53"}],"units":"Participants"}],"description":"The percentage of patients that achieve at least a sCR (Stringent Complete Response), at least a VGPR (Very Good Partial Response) and at least a PR (Partial Response) will be determined.\n\nsCR is defined as:\n\n* Negative immunofixation on the serum and urine and\n* Disappearance of any soft tissue plasmacytomas and\n* \\< 5% plasma cells in bone marrow and\n* Normal SFLC ratio and\n* Absence of clonal cells in bone marrow\n\nVGPR is defined as:\n\n* Serum and urine M-protein detectable by immunofixation but not on electrophoresis or\n* ≥ 90% reduction in serum M-component with urine M-component \\< 100 mg per 24 hours\n\nPR is defined as:\n\n* ≥ 50% reduction of serum M-protein and reduction in 24-hour urinary M-protein by ≥ 90% or to \\< 200 mg per 24 hours\n* If present at baseline, a ≥ 50% reduction in the size of soft tissue plasmacytomas is also required","groups":[{"description":"Carfilzomib will be administered as an IV infusion on Days 1, 2, 8, 9, 15, and 16 of a 28-day cycle for Cycles 1 - 8 (induction) and on Days 1, 2, 15, and 16 of a 28-day cycle for Cycles 9+ (maintenance).\n\nLenalidomide will be administered PO daily at 25 mg on Days 1- 21 of the 28-day cycle for Cycles 1 - 8+.\n\nDexamethasone will be administered PO or IV between 30 minutes and 4 hours preceding the carfilzomib push.","id":"OG000","title":"Carfilzomib, Lenalidomide w/Dexamethasone"}],"paramType":"NUMBER","reportingStatus":"POSTED","timeFrame":"4 Months After Treatment Start","title":"The Percentage of Patients That Achieve a Response to Treatment","type":"PRIMARY","unitOfMeasure":"percentage of patients"}