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(n=38,26)"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"11.60","upperLimit":"18.74","value":"15.167"},{"groupId":"OG001","lowerLimit":"1.925","upperLimit":"8.841","value":"5.383"}]}],"title":"Appetite loss wk 12 chge (n=217,239)"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"12.39","upperLimit":"20.76","value":"16.574"},{"groupId":"OG001","lowerLimit":"1.918","upperLimit":"9.804","value":"5.861"}]}],"title":"Appetite loss wk 24 chge (n=151,176)"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-2.08","upperLimit":"10.07","value":"3.999"},{"groupId":"OG001","lowerLimit":"-9.99","upperLimit":"4.061","value":"-2.963"}]}],"title":"Appetite loss wk 48 chge (n=38,26)"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"0.667","upperLimit":"7.603","value":"4.135"},{"groupId":"OG001","lowerLimit":"3.104","upperLimit":"9.735","value":"6.42"}]}],"title":"Constipation wk 12 chge (n=215,240)"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-3.64","upperLimit":"3.337","value":"-0.153"},{"groupId":"OG001","lowerLimit":"-2.73","upperLimit":"5.782","value":"0.524"}]}],"title":"Constipation wk 24 chge (n=151,177)"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-5.57","upperLimit":"4.851","value":"-0.358"},{"groupId":"OG001","lowerLimit":"-7.26","upperLimit":"5.373","value":"-0.946"}]}],"title":"Constipation wk 48 chge (n=38,25)"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"15.04","upperLimit":"22.74","value":"18.888"},{"groupId":"OG001","lowerLimit":"6.452","upperLimit":"13.96","value":"10.206"}]}],"title":"Diarrhea wk 12 chge (n=217,241)"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"18.46","upperLimit":"27.87","value":"23.163"},{"groupId":"OG001","lowerLimit":"11.98","upperLimit":"20.83","value":"16.406"}]}],"title":"Diarrhea wk 24 chge (n=150,177)"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"14.02","upperLimit":"26.94","value":"20.48"},{"groupId":"OG001","lowerLimit":"3.422","upperLimit":"18.57","value":"10.996"}]}],"title":"Diarrhea wk 48 chge (n=38,26)"}],"denoms":[{"counts":[{"groupId":"OG000","value":"387"},{"groupId":"OG001","value":"381"}],"units":"Participants"}],"description":"The EORTC QLQ-C30 measures functional dimensions (physical, role, emotional, cognitive, and social), three multi-item symptom scales (fatigue, nausea/vomiting, and pain), six single-item symptom scales (dyspnea, sleep disturbance, appetite loss, constipation, diarrhea and financial impact) and a global health status/QoL scale. Disease Symptom is the sum of 30 questions, total score ranges from 0 (best possible outcome) to 100 (worst possible outcome)\", All subscales of EORTC QLQ-C30 have the same score range of 0 -100. For global health status and other functional scales,an increase from baseline indicates improvement of QoL. Whereas for symptoms scales, fatigue, dyspnea, insomnia, appetite loss, constipation and diarrhea, decrease in scores from baseline indicate improvement in symptoms.","dispersionType":"95% Confidence Interval","groups":[{"description":"Panobinostat was given 20 mg hard gelatin capsules . Bortezomib was given at 1.3 mg/m2 as a 3 to 5 second bolus intravenous (IV)injection. Dexamethasone was given as an oral dose of 20 mg/day.","id":"OG000","title":"Panobinostat + Bortezomib"},{"description":"Placebo was given as a hard gelatin capsule in the image of Panobinostat . Bortezomib was given at 1.3 mg/m2 as a 3 to 5 second bolus intravenous (IV) injection. Dexamethasone was given as an oral dose of 20 mg/day.","id":"OG001","title":"Placebo + Bortezomib"}],"paramType":"LEAST_SQUARES_MEAN","populationDescription":"Full Analysis Set","reportingStatus":"POSTED","timeFrame":"12, 24 and 48 weeks","title":"European Organization for Research and Treatment of Cancer Multiple Myeloma Module (EORTC ) QLQ-C30 - Summary Statistics by Treatment Group","type":"SECONDARY","unitOfMeasure":"score on a scale"}