{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"14","upperLimit":"31","value":"23"},{"groupId":"OG001","lowerLimit":"21","upperLimit":"42","value":"30"},{"groupId":"OG002","lowerLimit":"38","upperLimit":"60","value":"49"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"75"},{"groupId":"OG001","value":"69"},{"groupId":"OG002","value":"75"}],"units":"Participants"}],"description":"Percentage of patients with complete remission after 3 month of treatment. Percentage values are rounded to whole numbers.","dispersionType":"95% Confidence Interval","groups":[{"description":"Arm A Methotrexate 3.5 g/m2 (0.5 g/m2 in 15 min. + 3 g/m2 in 3-hr infusion) d 1 Cytarabine 2 g/m2 1 hr infusion, twice a day (every 12 hs.) d 2 - 3\n\nMethotrexate: Methotrexate 3.5 g/m2 (0.5 g/m2 in 15 min. + 3 g/m2 in 3-hr infusion) on day 1, every 3 weeks for a maximum of 4 courses.\n\nAra-C: Cytarabine 2 g/m2 (1 hr infusion, twice a day every 12 hours), on d 2 - 3 every 3 weeks for a maximum of 4 courses","id":"OG000","title":"Arm A / MTX + AraC"},{"description":"Arm B Rituximab 375 mg/m2 conventional infusion d -5 \\& 0 Methotrexate 3.5 g/m2 0.5 g/m2 in 15 min. + 3 g/m2 in 3-hr infusion d 1 Cytarabine 2 g/m2 1 hr infusion, twice a day (every 12 hs.) d 2 - 3\n\nMethotrexate: Methotrexate 3.5 g/m2 (0.5 g/m2 in 15 min. + 3 g/m2 in 3-hr infusion) on day 1, every 3 weeks for a maximum of 4 courses.\n\nAra-C: Cytarabine 2 g/m2 (1 hr infusion, twice a day every 12 hours), on d 2 - 3 every 3 weeks for a maximum of 4 courses\n\nRituximab: Rituximab 375 mg/m2 conventional infusion on day - 5 \\& 0 every 3 weeks for a maximum of 4 cycles","id":"OG001","title":"Arm B / MTX + Ara-C + Rituximab"},{"description":"Arm C Rituximab 375 mg/m2 conventional infusion d -5 \\& 0 Methotrexate 3.5 g/m2 0.5 g/m2 in 15 min. + 3 g/m2 in 3-hr infusion d 1 Cytarabine 2 g/m2 1 hr infusion, twice a day (every 12 hs.) d 2 - 3 Thiotepa 30 mg/m2 30 min. Infusion d 4\n\nMethotrexate: Methotrexate 3.5 g/m2 (0.5 g/m2 in 15 min. + 3 g/m2 in 3-hr infusion) on day 1, every 3 weeks for a maximum of 4 courses.\n\nAra-C: Cytarabine 2 g/m2 (1 hr infusion, twice a day every 12 hours), on d 2 - 3 every 3 weeks for a maximum of 4 courses\n\nRituximab: Rituximab 375 mg/m2 conventional infusion on day - 5 \\& 0 every 3 weeks for a maximum of 4 cycles\n\nThiotepa: ARM C: Thiotepa 30 mg/m2 (30 min. Infusion) on day 4 every 3 weeks for a maximum of 4 courses ARM E: Thiotepa 5 mg/kg in 250 ml saline sol 2-hr inf. every 12 hrs days -5 \\& -4","id":"OG002","title":"Arm C / MTX + Ara-C + Rituximab+Thiotepa"}],"paramType":"NUMBER","reportingStatus":"POSTED","timeFrame":"3 months after treatment start","title":"Complete Remission Rate After Primary Chemotherapy","type":"PRIMARY","unitOfMeasure":"Percentage of participants"}