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Patients are followed for up to 10 years following end of therapy.\n\nDactinomycin: Given IV\n\nDoxorubicin Hydrochloride: Given IV\n\nRadiation Therapy: Undergo radiation therapy\n\nTherapeutic Conventional Surgery: Undergo surgical resection\n\nVincristine Sulfate: Given IV","id":"BG000","title":"Arm 1 (Bilateral Wilms Tumors)"},{"description":"Patients start with either 2 drug or three drug chemotherapy (Regimen VA, VAD) and are evaluated a 6 and 12 weeks for feasibility of undergoing a partial nephrectomy. At week 12 definitive surgery takes place followed by chemotherapy.\n\nDactinomycin: Given IV\n\nDoxorubicin Hydrochloride: Given IV\n\nRadiation Therapy: Undergo radiation therapy\n\nTherapeutic Conventional Surgery: Undergo surgical resection\n\nVincristine Sulfate: Given IV","id":"BG001","title":"Arm 2 (Unilateral High Risk Tumors Bilaterally Predisposed)"},{"description":"Patients with this rare disease are diagnosed based on cross-sectional imaging characteristics and undergo 2 drug chemotherapy (Regimen;VA). Patients are reassessed at 6 weeks and 12 weeks. If disease has responded or stayed stable chemotherapy is completed for 19 weeks (Regimen EE4A). If disease has progress a biopsy is performed to assess histology and adjust therapy based on the biopsy. This therapy may include, nephrectomy, chemotherapy or radiation therapy.\n\nDactinomycin: Given IV\n\nDoxorubicin Hydrochloride: Given IV\n\nRadiation Therapy: Undergo radiation therapy\n\nTherapeutic Conventional Surgery: Undergo surgical resection\n\nVincristine Sulfate: Given IV","id":"BG002","title":"Arm 3 (DHPLN)"},{"description":"Total of all reporting groups","id":"BG003","title":"Total"}],"measures":[{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","spread":"22.22","value":"32.03"},{"groupId":"BG001","spread":"22.12","value":"34.70"},{"groupId":"BG002","spread":"8.70","value":"13.26"},{"groupId":"BG003","spread":"22.12","value":"31.78"}]}]}],"dispersionType":"STANDARD_DEVIATION","paramType":"MEDIAN","title":"Age, Continuous","unitOfMeasure":"Months"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","value":"119"},{"groupId":"BG001","value":"23"},{"groupId":"BG002","value":"5"},{"groupId":"BG003","value":"147"}],"title":"Female"},{"measurements":[{"groupId":"BG000","value":"82"},{"groupId":"BG001","value":"16"},{"groupId":"BG002","value":"4"},{"groupId":"BG003","value":"102"}],"title":"Male"}]}],"paramType":"COUNT_OF_PARTICIPANTS","title":"Sex: Female, Male","unitOfMeasure":"Participants"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","value":"27"},{"groupId":"BG001","value":"3"},{"groupId":"BG002","value":"0"},{"groupId":"BG003","value":"30"}],"title":"Hispanic or Latino"},{"measurements":[{"groupId":"BG000","value":"168"},{"groupId":"BG001","value":"35"},{"groupId":"BG002","value":"8"},{"groupId":"BG003","value":"211"}],"title":"Not Hispanic or Latino"},{"measurements":[{"groupId":"BG000","value":"6"},{"groupId":"BG001","value":"1"},{"groupId":"BG002","value":"1"},{"groupId":"BG003","value":"8"}],"title":"Unknown or Not Reported"}]}],"paramType":"COUNT_OF_PARTICIPANTS","title":"Ethnicity (NIH/OMB)","unitOfMeasure":"Participants"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","value":"0"},{"groupId":"BG001","value":"1"},{"groupId":"BG002","value":"0"},{"groupId":"BG003","value":"1"}],"title":"American Indian or Alaska Native"},{"measurements":[{"groupId":"BG000","value":"3"},{"groupId":"BG001","value":"1"},{"groupId":"BG002","value":"0"},{"groupId":"BG003","value":"4"}],"title":"Asian"},{"measurements":[{"groupId":"BG000","value":"0"},{"groupId":"BG001","value":"0"},{"groupId":"BG002","value":"0"},{"groupId":"BG003","value":"0"}],"title":"Native Hawaiian or Other Pacific Islander"},{"measurements":[{"groupId":"BG000","value":"31"},{"groupId":"BG001","value":"5"},{"groupId":"BG002","value":"1"},{"groupId":"BG003","value":"37"}],"title":"Black or African American"},{"measurements":[{"groupId":"BG000","value":"142"},{"groupId":"BG001","value":"29"},{"groupId":"BG002","value":"7"},{"groupId":"BG003","value":"178"}],"title":"White"},{"measurements":[{"groupId":"BG000","value":"0"},{"groupId":"BG001","value":"0"},{"groupId":"BG002","value":"0"},{"groupId":"BG003","value":"0"}],"title":"More than one race"},{"measurements":[{"groupId":"BG000","value":"25"},{"groupId":"BG001","value":"3"},{"groupId":"BG002","value":"1"},{"groupId":"BG003","value":"29"}],"title":"Unknown or Not Reported"}]}],"paramType":"COUNT_OF_PARTICIPANTS","title":"Race (NIH/OMB)","unitOfMeasure":"Participants"}]}