{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"33","upperLimit":"62","value":"47"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"36"}],"units":"Participants"}],"description":"Overall response rate is percentage of participants with complete (CR), very good partial (VGPR), partial (PR), or minimal response (MR) as best response during treatment.\n\nCR\n\n* Disappearance of monoclonal protein by immunofixation\n* No histologic evidence of bone marrow involvement\n* Resolution of any adenopathy/organomegaly (confirmed by CT scan), or signs or symptoms attributable to WM.\n* Second immunofixation required for confirmation.\n\nVGPR\n\n-At least 90% reduction of serum monoclonal IgM concentration on protein electrophoresis.\n\nPR\n\n* At least 50% reduction of serum monoclonal IgM concentration on protein electrophoresis and at least 50% decrease in adenopathy/organomegaly on physical examination or on CT scan.\n* No new symptoms or signs of active disease.\n\nMR\n\n* At least 25% but less than 50% reduction of serum monoclonal IgM by protein electrophoresis.\n* No new symptoms or signs of active disease.","dispersionType":"90% Confidence Interval","groups":[{"description":"30 mg three days a week (Mondays, Wednesdays and Fridays).\n\n1 cycle was 28 days\n\nDose modifications for attributable toxicities allowed for reduction to:\n\n* 25 mg, 20 mg three times a week every week\n* Or 20 mg three times a week every other week. No dose re-escalation was allowed.\n\n  * The protocol was amended on 6/15/2010 because of concerns of toxicity to allow a starting dose of 25 mg; 12/36 (33%) patients were enrolled on the 25 mg dose.\n\nLBH589","id":"OG000","title":"LBH589"}],"paramType":"NUMBER","reportingStatus":"POSTED","timeFrame":"Assessed after 2nd cycle and then every subsequent cycle for 6 cycles. The median number of completed cycles of therapy was 5 (0- 32). As such observed up to ~32 months.","title":"Overall Response Rate","type":"PRIMARY","unitOfMeasure":"percentage of participants"}