{"denoms":[{"counts":[{"groupId":"BG000","value":"36"}],"units":"Participants"}],"groups":[{"description":"30 mg three days a week (Mondays, Wednesdays and Fridays).\n\n1 cycle was 28 days\n\nDose modifications for attributable toxicities allowed for reduction to:\n\n* 25 mg, 20 mg three times a week every week\n* Or 20 mg three times a week every other week. No dose re-escalation was allowed.\n\n  * The protocol was amended on 6/15/2010 because of concerns of toxicity to allow a starting dose of 25 mg; 12/36 (33%) patients were enrolled on the 25 mg dose.\n\nLBH589","id":"BG000","title":"LBH589"}],"measures":[{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","lowerLimit":"47","upperLimit":"80","value":"61.6"}]}]}],"dispersionType":"FULL_RANGE","paramType":"MEDIAN","title":"Age, Continuous","unitOfMeasure":"years"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","value":"22"}],"title":"Female"},{"measurements":[{"groupId":"BG000","value":"14"}],"title":"Male"}]}],"paramType":"COUNT_OF_PARTICIPANTS","title":"Sex: Female, Male","unitOfMeasure":"Participants"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","value":"0"}],"title":"American Indian or Alaska Native"},{"measurements":[{"groupId":"BG000","value":"0"}],"title":"Asian"},{"measurements":[{"groupId":"BG000","value":"0"}],"title":"Native Hawaiian or Other Pacific Islander"},{"measurements":[{"groupId":"BG000","value":"0"}],"title":"Black or African American"},{"measurements":[{"groupId":"BG000","value":"35"}],"title":"White"},{"measurements":[{"groupId":"BG000","value":"0"}],"title":"More than one race"},{"measurements":[{"groupId":"BG000","value":"1"}],"title":"Unknown or Not Reported"}]}],"paramType":"COUNT_OF_PARTICIPANTS","title":"Race (NIH/OMB)","unitOfMeasure":"Participants"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","lowerLimit":"804","upperLimit":"10300","value":"3240"}]}]}],"dispersionType":"FULL_RANGE","paramType":"MEDIAN","title":"Median IgM","unitOfMeasure":"mg/dL"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","lowerLimit":"0.63","upperLimit":"5.1","value":"2.06"}]}]}],"dispersionType":"FULL_RANGE","paramType":"MEDIAN","title":"Median M Spike","unitOfMeasure":"gm/dL"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","lowerLimit":"74","upperLimit":"388","value":"242"}]}]}],"dispersionType":"FULL_RANGE","paramType":"MEDIAN","title":"Median Platelets","unitOfMeasure":"platelets x 10^3 / mL"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","lowerLimit":"8.2","upperLimit":"14.5","value":"10.7"}]}]}],"dispersionType":"FULL_RANGE","paramType":"MEDIAN","title":"Median Hemoglobin","unitOfMeasure":"gm/dL"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","lowerLimit":"1.4","upperLimit":"7.4","value":"3.3"}]}]}],"dispersionType":"FULL_RANGE","paramType":"MEDIAN","title":"Median Beta 2 Microglobulin","unitOfMeasure":"mg/dL"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","lowerLimit":"5","upperLimit":"100","value":"70"}]}]}],"dispersionType":"FULL_RANGE","paramType":"MEDIAN","title":"Percentage of Bone Marrow Involvement","unitOfMeasure":"percentage of marrow"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","value":"29"}],"title":"Present"},{"measurements":[{"groupId":"BG000","value":"7"}],"title":"Absent"}]}],"paramType":"COUNT_OF_PARTICIPANTS","title":"Lymph Nodes and Hepatocyte Selection Medium Assessment by CT Scan Evidence of Disease","unitOfMeasure":"Participants"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","value":"7"}],"title":"High"},{"measurements":[{"groupId":"BG000","value":"14"}],"title":"Intermediate"},{"measurements":[{"groupId":"BG000","value":"15"}],"title":"Low"}]}],"description":"Measure Description: Low is defined as 1 or dewer of the following:\n\nHemoglobin (HB) \\<=11.5 g/dL Platelet (PT) \\<=100 x 10\\^9 / L Beta 2 Microglubin (B2M) \\> 3 mg/L Immunoglobulin M (IgM) \\> 7 g/dL\n\nIntermediate is defined as over 65 years old or two of the following:\n\nHB \\<=11.5 g/dL PT \\<=100 x 10\\^9 / L B2M \\> 3 mg/L IgM\\> 7 g/dL\n\nHigh is defined as more than 2 of the following:\n\nOver 65 years old HB \\<=11.5 g/dL PT \\<=100 x 10\\^9 / L B2M \\> 3 mg/L IgM\\> 7 g/dL","paramType":"COUNT_OF_PARTICIPANTS","title":"International Prognostic Scoring System for Waldenstrom Macroglobulinemia","unitOfMeasure":"Participants"}]}