{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","value":"1"}]}],"title":"UP, MS, BL, n=3"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"UP, NR, BL, n=3"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"UP, Neg, BL, n=3"},{"categories":[{"measurements":[{"groupId":"OG000","value":"2"}]}],"title":"UP, Trace, BL, n=3"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"UP, 1+, BL, n=3"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"UP, 2+, BL, n=3"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"UP, 3+, BL, n=3"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"UP, 4+, BL, n=3"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"UG, MS, BL, n=3"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"UG, NR, BL, 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BL,n=3"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"UOB, 3+, BL,n=3"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"UOB, Non haemolysed trace, BL,n=3"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"UOB, haemolysed trace, BL,n=3"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"pH, MS, BL, n=3"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"pH, NR, BL, n=3"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"pH, normal result, BL, n=3"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"pH, Neg, BL, n=3"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"pH, 5, BL, n=3"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"pH, 5.5, BL, n=3"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"pH, 6, BL, 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n=4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"UG, 30(2+), W24, n=4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"UG, 60(3+), W24, n=4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"UG, 110(4+), W24, n=4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"UK, MS, W24, n=4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"UK, NR, W24, n=4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"3"}]}],"title":"UK, Neg, W24, n=4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"}]}],"title":"UK, Trace(5), W24, n=4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"UK, Small(15), W24, n=4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"UK, Moderate(40), W24, n=4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"UK, Large(80), W24, n=4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"UK, Large(160), W24, n=4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"UOB, MS, W24, n=4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"UOB, NR, W24, n=4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"3"}]}],"title":"UOB, Neg, W24, n=4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"UOB, 1+, W24, n=4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"UOB, 2+, W24, n=4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"UOB, 3+, W24, n=4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"UOB, Non haemolysed trace, W24, n=4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"UOB, haemolysed trace, W24, n=4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"pH, MS, W24, n=4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"pH, NR, W24, n=4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"pH, normal result, W24, n=4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"pH, Neg, W24, n=4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"pH, 5, W24, n=4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"pH, 5.5, W24, n=4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"2"}]}],"title":"pH, 6, W24, n=4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"2"}]}],"title":"pH, 6.5, W24, n=4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"pH, 7, W24, n=4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"pH, 7.5,W24, n=4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"pH, 8, W24, n=4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"pH, 8.5, W24, n=4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"pH, 9, W24, n=4"}],"denoms":[{"counts":[{"groupId":"OG000","value":"15"}],"units":"Participants"}],"description":"Urinalysis parameters included: urine protein (UP), urine glucose (UG), urine ketones (UK), urine occult blood (UOB), and pH. The dipstick test gives results in a semi-quantitative manner. UP was categorized as missing (MS), no result (NR), negative (Neg), Trace, 1+, 2+, 3+ and 4+. UG results were categorized as MS, NR, Neg, normal, 5, 15(1+), 30(2+), 60(3+), 110(4+)UK parameters were categorized as as MS, NR, Neg, Trace(5), Small(15), Moderate(40), Large(80), Large(160). UOB parameters were categorized as MS, NR, Neg, 1+, 2+, 3+, Non haemolysed trace, and haemolysed trace. PH results were categorized as MS. NR, normalresult, Neg, and range of pH (from 5-9in increments of 0.5). Data for indicated parameters was reported at Baseline (BL) and Week 24 (W24). The Baseline value was the measurement taken at Day 1.","groups":[{"description":"Participants (par) aged between 1 and 17 years (Cohort 1 age group: 12 to 17 years, Cohort 2: 6 to 11 years and Cohort 3:1 to 5 years) received eltrombopag for 24 weeks. The starting dose for Cohort 1 was 25 mg, and par of East Asian ancestry received 12.5mg QD. For Cohort 2 starting dose was based on the body weight. Par with a bodyweight of \\<27 kg received 12.5 mg QD, par with a body weight of \\>=27 kg received 25 mg QD; par of East Asian ancestry with a body weight \\<27 kg received 12.5 mg QD, and with a body weight of \\>=27 kg received 25 mg QD. For Cohort 3, the starting dose was 0.7 mg/kg QD and 0.5 mg/kg/day for par of East Asian ancestry and the dose calculations were based on the body weight. The maximum dose allowed for all Cohorts was 75mg daily. For all par, individual dose titration was allowed based upon platelet response.","id":"OG000","title":"Part 1 Eltrombopag Dose-Finding Period"}],"paramType":"NUMBER","populationDescription":"Safety Population. Only those participants available at the specified time points were analyzed (represented by n=X in the category titles). Different participants may have been analyzed at different time points, so the overall number of participants analyzed reflects everyone in the safety Population.","reportingStatus":"POSTED","timeFrame":"Baseline and Week 24 of Part 1","title":"Number of Participants for the Indicated Urinalysis Parameters Tested by Dipstick at Baseline and Week 24 During the Dose-Finding Period, Part 1","type":"SECONDARY","unitOfMeasure":"Participants"}