{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-21.554","spread":"16.10377","upperLimit":"62.309","value":"21.8050"}]}],"title":"Physical Health Score"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-21.710","spread":"11.50688","upperLimit":"38.854","value":"8.2223"}]}],"title":"Psychosocial Health Score"}],"denoms":[{"counts":[{"groupId":"OG000","value":"125"}],"units":"Participants"}],"description":"The CHQ-PF50© is an instrument used to measure Health Related Quality of Life in children 5-18 from the parent's perspective. The questionnaire measures the following concepts: Physical functioning, Role/social emotional, Role/social behavior, Role/social physical, Bodily pain, General behavior, Mental health, Self-esteem, General health perception, Change in health, Parental impact - emotional, Parental impact - time, Family activities, and Family cohesion. Summaries are provided for Physical Health and Psychosocial Health. Scores range from 0-100. Increase in score represents improvement.","dispersionType":"Full Range","groups":[{"description":"In Part I participants received open label 4 mg/kg canakinumab subcutaneous injection every 4 weeks for up to 32 weeks. For the first 8 weeks Part Ia (4 weeks) and Ib (4 weeks) patients maintained a stable oral steroid dose (prednisone or equivalent) followed by Ic an up to 20 week steroid tapering period and then Id a 4 week stable steroid dose period. Participants were then randomized to receive either 4 mg/kg canakinumab subcutaneous injection or Placebo comparator in Part II and remained on the stable oral steroid dose for 24 weeks. At 24 weeks in Part II participants with a \\>0.2 mg/kg and ≤ 0.5 mg/kg and no flare could restart steroid tapering. If the steroid dose was ≤ 0.2 mg/kg participants continued to maintain their current dose for the remainder of Part II.","id":"OG000","title":"Canakinumab"}],"paramType":"MEDIAN","populationDescription":"Participants from the Full Analysis Set Part I-age 5 to 18 years.","reportingStatus":"POSTED","timeFrame":"Baseline, End of Part I ( Week 32)","title":"Part I: Change in Health Related Quality of Life Over Time by Child Health Questionnaire (CHQ-PF50)","type":"SECONDARY","unitOfMeasure":"Score on a scale"}