{"eventGroups":[{"description":"Patients received a single dose of subcutaneous(sc) injection of canakinumab (4 mg/kg) on Day 1. Maximal total single dose of canakinumab allowed was 300 mg. Any patient who required a dose greater than 150 mg (patients\\>37.5 kg) received two sc injections.","id":"EG000","otherNumAffected":17,"otherNumAtRisk":43,"seriousNumAffected":2,"seriousNumAtRisk":43,"title":"Canakinumab"},{"description":"Patients received a single dose matching placebo of canakinumab on day 1.","id":"EG001","otherNumAffected":3,"otherNumAtRisk":41,"seriousNumAffected":2,"seriousNumAtRisk":41,"title":"Placebo"}],"frequencyThreshold":"4","otherEvents":[{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA (Unspecified)","stats":[{"groupId":"EG000","numAffected":3,"numAtRisk":43},{"groupId":"EG001","numAffected":1,"numAtRisk":41}],"term":"Diarrhoea"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA (Unspecified)","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":43},{"groupId":"EG001","numAffected":0,"numAtRisk":41}],"term":"Abdominal pain"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"General disorders","sourceVocabulary":"MedDRA (Unspecified)","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":43},{"groupId":"EG001","numAffected":0,"numAtRisk":41}],"term":"Pyrexia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Infections and infestations","sourceVocabulary":"MedDRA (Unspecified)","stats":[{"groupId":"EG000","numAffected":3,"numAtRisk":43},{"groupId":"EG001","numAffected":1,"numAtRisk":41}],"term":"Nasopharyngitis"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Infections and infestations","sourceVocabulary":"MedDRA (Unspecified)","stats":[{"groupId":"EG000","numAffected":3,"numAtRisk":43},{"groupId":"EG001","numAffected":0,"numAtRisk":41}],"term":"Upper respiratory tract infection"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Infections and infestations","sourceVocabulary":"MedDRA (Unspecified)","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":43},{"groupId":"EG001","numAffected":0,"numAtRisk":41}],"term":"Bronchitis"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Nervous system disorders","sourceVocabulary":"MedDRA (Unspecified)","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":43},{"groupId":"EG001","numAffected":1,"numAtRisk":41}],"term":"Headache"}],"seriousEvents":[{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Blood and lymphatic system disorders","sourceVocabulary":"MedDRA (Unspecified)","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":43},{"groupId":"EG001","numAffected":0,"numAtRisk":41}],"term":"Leukopenia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Blood and lymphatic system disorders","sourceVocabulary":"MedDRA (Unspecified)","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":43},{"groupId":"EG001","numAffected":0,"numAtRisk":41}],"term":"Neutropenia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Hepatobiliary disorders","sourceVocabulary":"MedDRA (Unspecified)","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":43},{"groupId":"EG001","numAffected":0,"numAtRisk":41}],"term":"Hepatitis"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Infections and infestations","sourceVocabulary":"MedDRA (Unspecified)","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":43},{"groupId":"EG001","numAffected":0,"numAtRisk":41}],"term":"Bronchopneumonia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Infections and infestations","sourceVocabulary":"MedDRA (Unspecified)","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":43},{"groupId":"EG001","numAffected":0,"numAtRisk":41}],"term":"Varicella"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Infections and infestations","sourceVocabulary":"MedDRA (Unspecified)","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":43},{"groupId":"EG001","numAffected":1,"numAtRisk":41}],"term":"Gastroenteritis"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Neoplasms benign, malignant and unspecified (incl cysts and polyps)","sourceVocabulary":"MedDRA (Unspecified)","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":43},{"groupId":"EG001","numAffected":1,"numAtRisk":41}],"term":"Histiocytosis haematophagic"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Skin and subcutaneous tissue disorders","sourceVocabulary":"MedDRA (Unspecified)","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":43},{"groupId":"EG001","numAffected":0,"numAtRisk":41}],"term":"Rash maculo-papular"}]}