{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"652.817","value":"1678"},{"groupId":"OG001","spread":"1290.136","value":"2330.88"}]}],"title":"PKC412-Cycle 1/Day 1 (1 hour)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"226.771","value":"1762.5"},{"groupId":"OG001","spread":"936.039","value":"2449.09"}]}],"title":"PKC412-Cycle 1/Day 1 (2 hour)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"505.941","value":"1891.67"},{"groupId":"OG001","spread":"1421.365","value":"2287.5"}]}],"title":"PKC412-Cycle 1/Day 1 (3 hour)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"347.925","value":"939.17"},{"groupId":"OG001","spread":"2183.946","value":"2068.85"}]}],"title":"PKC412-Cycle 1/Day 1 (12 hour)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"936.659","value":"2444"},{"groupId":"OG001","spread":"2480.716","value":"2610.1"}]}],"title":"PKC412-Cycle 1/Day 5 (0 hour)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"643.467","value":"1945"},{"groupId":"OG001","spread":"2071.949","value":"2028"}]}],"title":"PKC412-Cycle 1/Day 7 (0 hour)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"773.881","value":"1832.5"},{"groupId":"OG001","spread":"379.953","value":"726"}]}],"title":"PKC412-Cycle 2/Day 1 (0 hour)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"505.146","value":"962"},{"groupId":"OG001","spread":"340.776","value":"674"}]}],"title":"PKC412-Cycle 3/Day 1 (0 hour)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"89.473","value":"106.18"},{"groupId":"OG001","spread":"148.469","value":"228.33"}]}],"title":"CGP62221-Cycle 1/Day 1 (1 hour)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"183.22","value":"208.95"},{"groupId":"OG001","spread":"281.882","value":"458.75"}]}],"title":"CGP62221-Cycle 1/Day 1 (2 hour)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"227.863","value":"333.4"},{"groupId":"OG001","spread":"276.938","value":"563.63"}]}],"title":"CGP62221-Cycle 1/Day 1 (3 hour)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"299.416","value":"424.35"},{"groupId":"OG001","spread":"385.698","value":"730.31"}]}],"title":"CGP62221-Cycle 1/Day 1 (12 hour)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"1756.778","value":"3182"},{"groupId":"OG001","spread":"2002.498","value":"3360.3"}]}],"title":"CGP62221-Cycle 1/Day 5 (0 hour)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"1400.071","value":"3390"},{"groupId":"OG001","spread":"1893.347","value":"2895"}]}],"title":"CGP62221-Cycle 1/Day 7 (0 hour)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"728.331","value":"2380"},{"groupId":"OG001","spread":"1057.585","value":"1614.14"}]}],"title":"CGP62221-Cycle 2/Day 1 (0 hour)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"189.16","value":"1140.67"},{"groupId":"OG001","spread":"923.668","value":"1759.2"}]}],"title":"CGP62221-Cycle 3/Day 1 (0 hour)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"42.325","value":"71.64"},{"groupId":"OG001","spread":"78.187","value":"111.58"}]}],"title":"CGP52421-Cycle 1/Day 1 (1 hour)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"54.831","value":"113.23"},{"groupId":"OG001","spread":"128.879","value":"189.65"}]}],"title":"CGP52421-Cycle 1/Day 1 (2 hour)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"78.405","value":"152.18"},{"groupId":"OG001","spread":"144.723","value":"236.19"}]}],"title":"CGP52421-Cycle 1/Day 1 (3 hour)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"68.198","value":"139.27"},{"groupId":"OG001","spread":"148.943","value":"259.52"}]}],"title":"CGP52421-Cycle 1/Day 1 (12 hour)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"259.014","value":"1018"},{"groupId":"OG001","spread":"509.208","value":"1581"}]}],"title":"CGP52421-Cycle 1/Day 5 (0 hour)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"453.963","value":"1269"},{"groupId":"OG001","spread":"341.97","value":"2129"}]}],"title":"CGP52421-Cycle 1/Day 7 (0 hour)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"1110.465","value":"2350"},{"groupId":"OG001","spread":"541.018","value":"2640"}]}],"title":"CGP52421-Cycle 2/Day 1 (0 hour)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"277.909","value":"2386.67"},{"groupId":"OG001","spread":"1511.529","value":"3488"}]}],"title":"CGP52421-Cycle 3/Day 1 (0 hour)"}],"denoms":[{"counts":[{"groupId":"OG000","value":"7"},{"groupId":"OG001","value":"15"}],"units":"Participants"}],"description":"The plasma concentrations of midostaurin (PKC412) and its two major metabolites, CGP62221 and CGP52421 were determined by using a validated liquid chromatography/tandem mass spectrometry method.","dispersionType":"Standard Deviation","groups":[{"description":"Participants received bodyweight and body surface area (BSA) stratified dose of midostaurin 30 mg/m\\^2 bid through oral route. The total daily dose in 30 mg/m\\^2 bid cohort was 60 mg/m\\^2.","id":"OG000","title":"Cohort 1: Midostaurin (30 Milligrams/Meters^2)"},{"description":"Participants received bodyweight and BSA stratified dose of midostaurin 60 mg/m\\^2 bid through oral route. The total daily dose in 60 mg/m\\^2 bid cohort was 120 mg/m\\^2.","id":"OG001","title":"Cohort 2: Midostaurin (60 mg/m^2)"}],"paramType":"MEAN","populationDescription":"The analysis was performed in pharmacokinetic (PK) set population defined as all safety set participants who had at least one valid (measurable) PK sample of midostaurin, and who had no significant restricted co-medications.","reportingStatus":"POSTED","timeFrame":"Day 1, Day 5, Day 7, Day 15 (Day 1 of Cycle 2), Day 29 (Day 1 of Cycle 3)","title":"Plasma Concentrations of Midostaurin and Its Metabolites CGP52421 and CGP62221","type":"SECONDARY","unitOfMeasure":"nanograms/milliliters (ng/mL)"}