{"description":"Toxicities documented per Common Terminology Criteria for Adverse Events (CTCAE) v3.0","eventGroups":[{"deathsNumAffected":21,"deathsNumAtRisk":96,"description":"CONDITIONING REGIMEN: Patients receive fludarabine phosphate IV over 30 minutes on days -6 to day -2 and treosulfan IV over 2 hours on days -6 to day -4. Patients also undergo total-body irradiation on day 0. TRANSPLANTATION: Patients undergo allogeneic peripheral blood stem cell transplantation or bone marrow transplantation on day 0. GVHD PROPHYLAXIS: Patients receive tacrolimus IV continuously or PO BID on days -1 to 56, followed by a taper until day 180 in the absence of GVHD. Patients also receive methotrexate IV on days 1, 3, 6 and 11.\n\ntreosulfan: Given IV\n\nfludarabine phosphate: Given IV\n\ntotal-body irradiation: Low dose starting at 2Gy\n\nperipheral blood stem cell transplantation: Given IV per institutional standard practice\n\ntacrolimus: Given IV or PO\n\nallogeneic bone marrow transplantation: Given IV per institutional standard practice\n\nallogeneic hematopoietic stem cell transplantation: Given IV per institutional standard practice\n\nmethotrexate: Given IV","id":"EG000","otherNumAffected":68,"otherNumAtRisk":96,"seriousNumAffected":17,"seriousNumAtRisk":96,"title":"Treatment (Allogeneic Transplantation)"}],"frequencyThreshold":"0","otherEvents":[{"organSystem":"Gastrointestinal disorders","stats":[{"groupId":"EG000","numAffected":23,"numAtRisk":96}],"term":"Mucositis"},{"organSystem":"Gastrointestinal disorders","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":96}],"term":"Mucosi"},{"organSystem":"Infections and infestations","stats":[{"groupId":"EG000","numAffected":56,"numAtRisk":96}],"term":"Infections"},{"organSystem":"Blood and lymphatic system disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":96}],"term":"Deep vein thrombosis"},{"organSystem":"General disorders","stats":[{"groupId":"EG000","numAffected":6,"numAtRisk":96}],"term":"Fatigue"},{"organSystem":"General disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":96}],"term":"Adrenal insufficiency"},{"organSystem":"Metabolism and nutrition disorders","stats":[{"groupId":"EG000","numAffected":6,"numAtRisk":96}],"term":"Hyperglycemia"},{"organSystem":"Eye disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":96}],"term":"Retinal central vein occlusion"},{"organSystem":"General disorders","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":96}],"term":"Dehydration"},{"organSystem":"General disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":96}],"term":"Proximal 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