{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","value":"300"}]}],"title":"MTD cyclophosphamide"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1.6"}]}],"title":"MTD bortezomib"},{"categories":[{"measurements":[{"groupId":"OG000","value":"30"}]}],"title":"MTD liposomal doxorubicin"}],"denoms":[{"counts":[{"groupId":"OG000","value":"6"}],"units":"Participants"}],"description":"If 3 patients of cohort 1 require dose reduction of one or more of the medications for toxicity attributed to the drug or drugs, then the starting dose level will be reduced for that drug or drugs for future patients. The initial dosing of drugs for cohort 2 will be permitted to be one dose level above the maximal tolerated doses of cohort 1. Note that this Outcome Measure shows MTD for cyclophosphamide, bortezomib and doxorubicin. MTD for dexamethasone is include in a separate table due to the different Unit of Measure.","groups":[{"description":"Patients with relapsed multiple myeloma receive cyclophosphamide IV or PO over 1 hour, bortezomib IV over 3 minutes, and dexamethasone IV or PO on days 1, 8, and 15. Patients also receive pegylated liposomal doxorubicin hydrochloride IV over 1 hour on day 8. Treatment repeats every 28 days for up to 4 courses in the absence of disease progression or unacceptable toxicity.\n\ncyclophosphamide: Given IV or PO\n\npegylated liposomal doxorubicin hydrochloride: Given IV\n\nbortezomib: Given IV\n\ndexamethasone: Given IV or PO","id":"OG000","title":"Relapsed Disease"}],"paramType":"NUMBER","populationDescription":"Patients with relapsed multiple myeloma who received cyclophosphomide, bortezomib, liposomal doxorubicin and dexamethasone. Note that the MTD for dexamethasone is in a separate table due to the different dosing unit.","reportingStatus":"POSTED","timeFrame":"Up to 90 days after initiation of study treatment","title":"Maximum Tolerated Dose of This Combination of Drugs as Assessed by the NCI Common Terminology Criteria for Adverse Events (CTCAE) Version 3.0 (Cohort 1) [MTD Cyclophosphamide, MTD Bortezmib, MTD Docxorubicin]","type":"PRIMARY","unitOfMeasure":"mg/m2"}