{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"9.2","value":"-8.7"},{"groupId":"OG001","spread":"9.5","value":"-8.5"},{"groupId":"OG002","spread":"9.4","value":"-7.8"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"137"},{"groupId":"OG001","value":"45"},{"groupId":"OG002","value":"133"}],"units":"Participants"}],"description":"Change in mean cigarettes per day","dispersionType":"Standard Deviation","groups":[{"description":"Patients receive oral varenicline once daily on days 1-3 and twice daily thereafter for a total of 6 months or when a comfortable level of smoking abstinence is reached.\n\nvarenicline: Given orally","id":"OG000","title":"Arm I"},{"description":"Patients receive oral varenicline placebo once daily on days 1-3 and twice daily thereafter for a total of 6 months or when a comfortable level of smoking abstinence is reached.\n\nplacebo: Given orally","id":"OG001","title":"Arm II"},{"description":"Patients receive a nicotine patch, with doses tapering over time for a total of 26 weeks. Patients also receive nicotine gum to quell breakthrough urges. Patients may stop treatment when a comfortable level of smoking abstinence is reached.\n\nnicotine: Given transdermally and orally","id":"OG002","title":"Arm III"}],"paramType":"MEAN","reportingStatus":"POSTED","timeFrame":"6-Months","title":"Change in Cigarettes Per Day","type":"SECONDARY","unitOfMeasure":"cigarettes/day"}