{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"12.61","value":"1.6"},{"groupId":"OG001","spread":"11.24","value":"-4.4"}]}],"title":"Day 8, n=113, 225"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"13.06","value":"3.1"},{"groupId":"OG001","spread":"13.51","value":"-2.7"}]}],"title":"Week 4, n=98, 208"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"15.03","value":"2.1"},{"groupId":"OG001","spread":"14.31","value":"-1.6"}]}],"title":"Week 8, n=66, 171"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"17.32","value":"1.1"},{"groupId":"OG001","spread":"11.67","value":"-2.4"}]}],"title":"Week 12, n=29, 103"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"16.78","value":"6.0"},{"groupId":"OG001","spread":"12.76","value":"-3.7"}]}],"title":"Week 16, n=31, 127"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"22.95","value":"0.6"},{"groupId":"OG001","spread":"11.71","value":"-3.4"}]}],"title":"Week 20, n=12, 57"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"18.14","value":"4.5"},{"groupId":"OG001","spread":"12.83","value":"-5.0"}]}],"title":"Week 24, n=21, 94"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"27.99","value":"-1.1"},{"groupId":"OG001","spread":"13.68","value":"-3.8"}]}],"title":"Week 28, n=7, 37"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"18.38","value":"-1.7"},{"groupId":"OG001","spread":"12.63","value":"-2.7"}]}],"title":"Week 32, n=12, 72"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"32.57","value":"-11.8"},{"groupId":"OG001","spread":"13.37","value":"0.9"}]}],"title":"Week 36, n=5, 24"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"30.19","value":"-8.2"},{"groupId":"OG001","spread":"12.84","value":"-2.4"}]}],"title":"Week 40, n=5, 58"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"16.09","value":"7.0"},{"groupId":"OG001","spread":"14.02","value":"-0.9"}]}],"title":"Week 44, n=3, 15"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"18.00","value":"9.0"},{"groupId":"OG001","spread":"14.38","value":"1.9"}]}],"title":"Week 48, n=3, 33"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0","value":"-8.0"},{"groupId":"OG001","spread":"16.96","value":"-3.4"}]}],"title":"Week 52, n=1, 5"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0","value":"31.0"},{"groupId":"OG001","spread":"15.14","value":"-0.4"}]}],"title":"Week 56, n=1, 24"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0","value":"0"},{"groupId":"OG001","spread":"15.13","value":"4.3"}]}],"title":"Week 60, n=0, 6"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0","value":"36.0"},{"groupId":"OG001","spread":"13.56","value":"-1.5"}]}],"title":"Week 64, n=1, 13"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0","value":"0"},{"groupId":"OG001","spread":"0.71","value":"9.5"}]}],"title":"Week 68, n=0, 2"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0","value":"14.0"},{"groupId":"OG001","spread":"12.60","value":"2.6"}]}],"title":"Week 72, n=1, 8"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0","value":"0"},{"groupId":"OG001","spread":"0","value":"5.0"}]}],"title":"Week 76, n=0, 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0","value":"24.0"},{"groupId":"OG001","spread":"16.08","value":"2.8"}]}],"title":"Week 80, n=1, 5"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0","value":"9.0"},{"groupId":"OG001","spread":"10.58","value":"-3.0"}]}],"title":"Week 88, n=1, 3"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0","value":"17.0"},{"groupId":"OG001","spread":"4.24","value":"-5.0"}]}],"title":"Week 96, n=1, 2"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0","value":"30.0"},{"groupId":"OG001","spread":"0","value":"1.0"}]}],"title":"Week 104, n=1, 1"}],"denoms":[{"counts":[{"groupId":"OG000","value":"113"},{"groupId":"OG001","value":"225"}],"units":"Participants"}],"description":"Change from baseline in on-therapy heart rate was calculated as the value at the indicated time points (Day 8 and Weeks 4, 8, 12, 16, 20, 24, 28, 32, 36, 40, 44, 48, 52, 56, 60, 64, 68, 72, 76, 80, 88, 96, and 104) minus the value at baseline.","dispersionType":"Standard Deviation","groups":[{"description":"Matching placebo tablets administered orally once daily for a duration until participants experienced disease progression, death, unacceptable toxicity, or participants withdrew consent","id":"OG000","title":"Placebo"},{"description":"Pazopanib 200 milligrams (mg) and 400 mg film-coated tablets (containing pazopanib monohydrochloride) administered orally at a dose of 800 mg once daily for a duration until participants experienced disease progression, death, unacceptable toxicity, or participants withdrew consent","id":"OG001","title":"Pazopanib"}],"paramType":"MEAN","populationDescription":"Safety Population. Data were analyzed for participants who were on-therapy and provided data at the indicated time point.","reportingStatus":"POSTED","timeFrame":"Baseline, Day 8, Weeks 4, 8, 12, 16, 20, 24, 28, 32, 36, 40, 44, 48, 52, 56, 60, 64, 68, 72, 76, 80, 88, 96, and 104","title":"Change From Baseline in Heart Rate","type":"SECONDARY","unitOfMeasure":"beats per minute"}